biomedical sciences research institute - Research - University of Ulster

More documents

Recommendations

Info

environmental remediation and as routes to new bioproducts. Recent biomedical sciences research in the Ternanlaboratory has focused on a systems biology approach to understanding stress response in the important humanpathogen, Clostridium difficile, as well as the development of nanostructured coatings to prevent biofouling of medicaldevices and collaboration with local industry to develop in situ treatment processes for reducing infective load inhealthcare environments.The completion of successful programmes of research by Dr Ternan has resulted in over 20 peer-reviewed publicationsand competitively awarded external funding in excess of £60k. The Ternan laboratory has recently characterised abiological pathway leading to the production of the antiviral compound, phosphonoacetate Analysis of this pathwaywas initially facilitated by funding from the Royal Society and a subsequent 2 year grant from the prestigious UKEngineering and Physical Sciences Research Council has enabled the Ternan laboratory to undertake a systemsbiology investigation of the pathway in collaboration with the School of Mechanical and Aerospace Engineering atQUB.Clostridium difficile has risen from relative obscurity 20 years ago to be recognised as an important hospital pathogen,responsible for a wide spectrum of enteric diseases. Limited post-genomic information currently exists on C. difficile.Therefore, a comprehensive post-genomic analysis of clinically relevant stress in C. difficile is underway in the Ternanlaboratory, which utilises proteomics, transcriptomics and biochemical analyses to further our understanding ofhow this pathogen works at a systems level. The work is driven in part by in silico analyses of potential drug targetsidentified in comparative studies followed by expression studies to determine the regulation of these virulencefactors. This work should lead to greater understanding of their physiological role, and thus allow the developmentof strategies to disrupt or interfere with that role, thereby weakening the pathogen. Overall the work should allowus to elevate our understanding of genome function in this important pathogen.The Ternan laboratory also delivers consultancy services for industrial partners. Recent clients include SeagateTechnologies, Invista Chemicals, Ltd., and Soltex Global Ltd. All these companies have benefited from the expertiseavailable within the Microbiology and Biotechnology Research Group and the Ternan laboratory.Dr Ternan currently supervises two PhD students and six MSc students and has previously supervised five MResstudents. He has acted as an expert reviewer for: Proteomics, Journal of Proteome Research, Journal of Bacteriology,Can. Journal of Microbiology, Water Research, Environmental Technology, Biodegradation, and also on three occasionsfor the Biotechnology and Biological Sciences Research Council. He is a member of the Society for GeneralMicrobiology, serving on the Irish Branch Committee from 1998-2001, holds a 1 st Dan black belt in Shotokan Karate,and has won gold in several international Karate competitions.In the period under review, Dr Ternan (along with Professor McMullan) provided consultancy services for InvistaTextiles, Londonderry, providing a “Report on wastewater treatment plant considerations to increase efficiency”. He68
also secured a Vacation Studentship from the Society for General Microbiology for a project entitled: “Realisation ofthe extracellular proteome of Clostridium difficile strain 630 using a novel biotinylation-driven enrichment strategy”.Publications:Graham RLJ, Sharma MK, Ternan NG, Weatherly DB, Tarleton RL, McMullan G; A Differential Semi-Quantitative GeLC-MS Analysis of Temporal Proteome Expression in the Emerging Nosocomial Pathogen Ochrobactrum anthropi. BMCGenome Biology (in press)Graham RLJ, Pollock CE, O’Loughlin SN, Ternan NG, Weatherly DB, Jackson PJ, Tarleton RL and McMullan G; (2007)Multidimensional analysis of the insoluble sub-proteome of Oceanobacillus iheyensis HTE831, an Alkaliphilic andhalotolerant deep-sea bacterium isolated from the Iheya ridge; Proteomics, 7: 82-91, 200769
Page 1:
BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5:
1 Foreword by the Pro Vice-Chancell
Page 6 and 7:
2 Foreword by the Research Institut
Page 8 and 9:
The BMSRI Research StructureThe BMS
Page 10 and 11:
BMSRI Core FacilitiesContact: Karen
Page 12 and 13:
of Metabolomics, pharmacy, nutritio
Page 14 and 15:
BMSRI Academic Heads new Regional N
Page 16 and 17:
4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19:
Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
Page 96 and 97: Publications:Lees-Murdock DJ, Lau H
Page 98 and 99: Publications:Lees-Murdock DJ, Lau H
Page 100 and 101: 11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 102 and 103: Kravtsov V, Swain M, Schuster A, Du
Page 104 and 105: Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107: Zhang et al; Incorporating Feature
Page 108 and 109: Bala P, Baldridge K, Benfenati E, C
Page 110 and 111: In addition there is a growing them
Page 112 and 113: Clinical work involves development
Page 114 and 115: In 2009 he was appointed Chairman o
Page 116 and 117: Stevenson TR, Goodall EA and Moore
Page 118 and 119: Dr Raymond BeirneLecturer in Optome
Page 120 and 121:
Dr Julie McClellandLecturer in Opto
Page 122 and 123:
Graham JE, Moore JE, Moore JE, McCl
Page 124 and 125:
Research Staff:Dr David OrrSenior R
Page 126 and 127:
Dr Victoria McGilliganResearch Asso
Page 128 and 129:
13. Externally Funded Projects duri
Page 130 and 131:
Grant Holder Anderson, Prof RSFundi
Page 132 and 133:
Funding Body Royal Irish AcademyAmo
Page 134 and 135:
14. BIOMEDICAL SCIENCES RESEARCH IN
Page 136 and 137:
Student: Simon GenglerTitle: Effect
Page 138 and 139:
Student: Anisha MazumdarTitle: Anal
Page 140 and 141:
Student: Clare RyanTitle: How does
Page 142 and 143:
CONGRATULATIONS TO THE FOLLOWING PO
show all

biomedical sciences research institute - Research - University of Ulster

Create successful ePaper yourself

Delete template?

Save as template?