biomedical sciences research institute - Research - University of Ulster

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6. CANCER AND AGEING RESEARCH GROUPRESEARCH STRATEGYCancer is most commonly a disease of old age, brought on by cumulative mutagenic responses to DNA damage;probably, some of the factors producing ageing are similar. This Group has, therefore, investigated factors affecting themutability and growth controls of human cells and of a variety of animal models. Cancer-related work encompassesa range of topics relevant to therapy, diagnosis or causation. Direct research into ageing involves studies of ageingsyndromes: such as Alzheimer’s Disease and Werner Syndrome.The Group uses a wide range of facilities, including proteomic facilities with 2D electrophoresis and a spot-pickingrobot, a QTOF Ultima mass spectrometer, Xray and caesium gamma sources, whole-body imaging for mice, andventilated isolation cages for handling immuno-compromised mice.MEMBERS OF THE GROUPAcademic Staff:Professor Stephen Downes, Group LeaderProfessor of Cancer BiologyContact Details:T: +44 (0)28 70324121cs.downes@ulster.ac.ukProfessor Downes’ main research interests are:in cancer biology:• Cell cycle control, concentrating on control of progression into G2/M by decatenation, damage and replicationcheckpoints;• DNA damage as detected by the Comet assay, and variations of that assay;• Creation of novel vectors to display results of different classes of DNA damage;• DNA repair mechanisms (excision, postreplication, mismatch); and molecular basis of repair deficiency inthymidine kinase defective cells;• Signaling networks, particularly in lung and colon cancer;• Nutritional aspects of carcinogenesis, particularly mechanisms by which dietary folate or salicylate insufficiencymay affect colon cancer.in ageing:• Mechanisms defective in progeroid syndromes, especially Werner syndrome and Cockayne syndrome;• Excess DNA damage in Alzheimer syndrome.30
Research deliverables:Better understanding of mechanisms of carcinogenesis and of ageing, leading to rationally based strategies for avoiding,delaying or treating them.Better understanding of the rather tenuous relationship between nationality and ethnic origins.Professor Downes was a Member of the 2008 RAE Sub-Panel 12, Allied Health Professions and Studies and an invitedspeaker on: “Systems Biology for Medical Applications”, FW6 Workshop on Cancer-Ageing link, Paris, in February2008.Publications:Fuss H, Kurth MJ, Downes CS, Dubitzky W; Deactivation of Src family kinases: Hypothesis testing using a Monte Carlosensitivity analysis of systems-level properties, Journal of Computational Biology, 14: 1185-1200, 2007Graham JE, Moore JE, Jiru X, Moore JE, Goodall EA, Dooley JS, Hayes VE, Dartt DA, Downes CS, Moore TC; Ocularpathogen or commensal: a PCR-based study of surface bacterial flora in normal and dry eyes; Investigative OphthalmolVis Sci., 48: 5616-23, 2007Sanderson P, Stone E, Kim YI, Mathers JC, Kampman E, Downes CS, Muir KR and Baron JA; Folate and colo-rectalcancer risk; British Journal of Nutrition, 98: 1299-304, 2007Tömöry G, Csányi B, Bogácsi-Szabó E, Kalmár T, Czibula Á, Csõsz A, Priskin K, Mende B, Langó P, Downes CS and RaskóI; Comparison of maternal lineages and phylogenetic analysis of ancient and modern Hungarian populations; AmericanJournal of Phys. Anthropol., 134, 354-368, 2007Csányi B, Bogácsi-Szabó E, Tömöry G, Czibula Á, Priskin K, Csõsz A, Mende B, Langó P, Csete K, Zsolnai A, ConantEK, Downes CS and Raskó I; Y-chromosome analysis of ancient Hungarian and two modern Hungarian-speakingpopulations from the Carpathian Basin; Ann Human Genetics, 72: 519-534, 2008Fuss H, Dubitzky W, Downes CS and Kurth MJ; Src family kinases and receptors: analysis of three activation mechanismsby dynamic systems modeling; Biophysical Journal, 94: 1995-2006, 2008Graham JE, Graham RLJ, Beirne R, McGilligan VE, Downes CS, Moore JE, Moore CBT, McMullan G; The use ofconjunctival swab for the proteomic characterisation of Dry Eye Syndrome; Journal of Proteomics and Bioinformatics;1: 20-33, 2008Wasson GR, Downes CS and McKelvey-Martin VJ; The use of the Comet assay in the study of human nutrition andcancer; Mutagenesis, 23: 153-162, 2008Professor Stephanie McKeownProfessor of Cancer Biology31
Page 1: BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5: 1 Foreword by the Pro Vice-Chancell
Page 6 and 7: 2 Foreword by the Research Institut
Page 8 and 9: The BMSRI Research StructureThe BMS
Page 10 and 11: BMSRI Core FacilitiesContact: Karen
Page 12 and 13: of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
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Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
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Dr Maeve KerrResearch AssociateCont
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Memberships of External Committees/
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Indicators of Esteem:Professor McNu
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were examined. The intervention and
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Within this work both short-term an
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micronutrient supplementation at a
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10. STEM CELL & EPIGENETICS RESEARC
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Publications:Lees-Murdock DJ, Lau H
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Publications:Lees-Murdock DJ, Lau H
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11. SYSTEMS BIOLOGY RESEARCH GROUPT
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Kravtsov V, Swain M, Schuster A, Du
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Dr Daniel BerrarLecturer in Biomedi
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Zhang et al; Incorporating Feature
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Bala P, Baldridge K, Benfenati E, C
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In addition there is a growing them
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Clinical work involves development
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In 2009 he was appointed Chairman o
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Stevenson TR, Goodall EA and Moore
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Dr Raymond BeirneLecturer in Optome
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Dr Julie McClellandLecturer in Opto
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Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
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Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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