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McClean PL, Irwin N, Hunter K, Gault VA and Flatt PR; (Pro 3 )GIP[mPEG]: Novel long-acting mini-PEGylated gastricinhibitory polypeptide antagonist for obesity-diabetes therapy; British Journal of Pharmacology, 155: 690-701, 2008Taylor A, Irwin N, McKillop AM, Flatt PR and Gault VA; Sub-chronic administration of 11beta-HSD1 inhibitor,carbenoxolone, improves glucose tolerance and insulin insensitivity in mice with diet-induced obesity; Biol. Chem.,389: 441-445, 2008Kerr BD, Irwin N, Flatt PR and Gault VA; Prolonged GIP receptor activation using stable mini-PEGylated GIP improvesglucose homeostasis and beta cell function in age-related glucose intolerance; Peptides (in press)Dr JT McCluskeyLecturer in Biomedical SciencesContact details:T: +44 (0)28 70324882jt.mccluskey@ulster.ac.ukBrief profile:BSc Hons from University of Glasgow (1991) and DPhil from University of Oxford (1995) in Developmental andCellular Biology. Postdoctoral Research at King’s College London (1995 – 1997), University College London (1997-1998) and University of Ulster (1998 – 2007) prior to taking up present position as Lecturer in Biomedical Sciencesat the University of Ulster, Coleraine (2007). Over 30 peer-reviewed publications and invited speaker at internationaland national conferences.Main research interests:• Cellular and molecular events in novel human and rodent insulin-secreting pancreatic beta cell lines• Formation of pancreatic endocrine cells from embryonic stem cells• Glucose and lipid toxicity, drug sensitisation, and actions of cytotoxic agentsPublications:Liu HK, McCluskey JT, McClenaghan NH, Flatt PR; Streptozotocin-resistant BRIN-BD11 cells possess a wide spectrumof toxin tolerance and enhanced insulin-secretory capacity; Endocrine, 32: 20-29, 2007Gault VA, McClean PL, Irwin N, Power GJ, McCluskey JT, Flatt PR; Effects of subchronic treatment with the long-actingglucose-dependent insulinotropic polypeptide receptor agonist, N-AcGIP, on glucose homeostasis in streptozotocininduceddiabetes; Pancreas, 35: 73-79, 2007Patterson S, Scullion SM, McCluskey JT, Flatt PR, McClenaghan NH; Prolonged exposure to homocysteine resultsin dimished but reversible pancreatic beta-cell responsiveness to insulinotropic agents. Diabetes Metab. Res. Rev.,23(4):324-334, 2007Liu HK, McCluskey JT, McClenaghan NH, Flatt PR; Iterative exposure of clonal BRIN-BD11 cells to ninhydrin enablesselection of robust toxin-resistant cells but with decreased gene expression of insulin secretory function; Pancreas,36: 294-301, 2008McClean PL, Gault VA, Irwin N, McCluskey JT, Flatt PR; Daily administration of the GIP-R antagonist (Pro3)GIP instreptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti-obesity diabetesactions of (Pro3)GIP; Diabetes Obes. Metab., 10: 336-342, 200852
Dr A HillLecturer in DieteticsContact details:T: +44 (0)28 70324128aj.hill@ulster.ac.ukBrief profile:Qualified with BSc Dietetics in Queen Margaret Edinburgh. MSc and PhD Huma n Nutrition from University of Ulster.Worked as a clinical dietitian for 16 years mainly in Royal Hospitals Belfast specialising in dietary management ofadults with diabetes before taking up a post as Lecturer in Dietetics in University of Ulster 2006.Clinical research links:Collaborate with diabetic physicians in Royal Hospitals, Belfast on local arm of:• Hyperglycaemia and Adverse Pregnancy Outcome Study (HAPO)• Diabetes and Pre-eclampsia Intervention Study (DAPIT).Main research interests:• Dietary management of pregnant women with diabetes in relation to pregnancy outcomes• Relationships between diet and glycaemic control in those who develop gestational diabetes.Research Staff:Dr N IrwinResearch Fellow in DiabetesContact details:T: +44 (0)28 70324313n.irwin@ulster.ac.ukBrief profile:BSc Hons and PhD from University of Ulster. Research Associate at the University of Ulster (2004-07) before takingup current appointment as Research Fellow in Diabetes at the University of Ulster in 2007. Dr Irwin is a patentholder and author of over 80 peer-reviewed publications and an invited speaker at international and national conferences.Main research interests:• Therapeutic development of human peptide hormones• Glucose homeostasis in aging• Hormonal regulation of feeding/obesityDuring the year under review, Dr Irwin obtained funding of £5000 from the PhD Studentship Top-up Schemesponsored by the Health and Personal Social Services Research and Development Office (NI) to provide additionalsupport a PhD project entitled “Assessment of the potential of GIP receptor antagonism for diabetes therapy”. He alsoobtained pilot funding of £9,780 (jointly with Professor Finbarr O’Harte) through the University’s Research CouncilSupport Fund for a project entitled: “Evaluation of novel glucagons receptor antagonists for diabetes therapy”.53
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BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5: 1 Foreword by the Pro Vice-Chancell
Page 6 and 7: 2 Foreword by the Research Institut
Page 8 and 9: The BMSRI Research StructureThe BMS
Page 10 and 11: BMSRI Core FacilitiesContact: Karen
Page 12 and 13: of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
Page 96 and 97: Publications:Lees-Murdock DJ, Lau H
Page 98 and 99: Publications:Lees-Murdock DJ, Lau H
Page 100 and 101: 11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 102 and 103: Kravtsov V, Swain M, Schuster A, Du
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Dr Daniel BerrarLecturer in Biomedi
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Zhang et al; Incorporating Feature
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Bala P, Baldridge K, Benfenati E, C
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In addition there is a growing them
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Clinical work involves development
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In 2009 he was appointed Chairman o
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Stevenson TR, Goodall EA and Moore
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Dr Raymond BeirneLecturer in Optome
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Dr Julie McClellandLecturer in Opto
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Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
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Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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