biomedical sciences research institute - Research - University of Ulster

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Publications:Bigot S, Lucas L, Morrow P, Mitchell CA, Saetzler K; Estimating Leukocyte Velocities from High-speed 1d Line ScansOriented Orthogonal to Blood Flow; ISBI 2007: 376-379, 2007Rutland CS, Mitchell CA, Nasir M, Konerding MA, Drexler HCA; Microphthalmia, persistent hyperplastic hyaloidvasculature and lens anomalies following over-expression of VEGF-A 188from the aA-crystallin promoter; MolecularVision, 13: 47-56, 2007Lucas LAG, S Pop SR, Machado MJC, Ma YL, Waters SL, Richardson G, Saetzler K, Jensen OE and Mitchell CA;Experimental and theoretical modelling of blind-ended vessels within a developing angiogenic plexus; MicrovascularResearch, 76: 161-168, 2008Lee PD, Atwood RC, Rockett P, Konerdingn MA, Jones JR, Mitchell CA; Proceedings of SPIE, Vol. 7078, 70780E, 2008[DOI:10.1117/12.795558]Research Staff:Dr Barry O’HaganResearch FellowContact Details:T: +44 (0)28 70324765bmg.ohagan@ulster.ac.ukDr O’Hagan’s main research interests and activities involve the use and development of advanced imaging systemsfor use in a variety of biological research projects.He is responsible for the routine maintenance, alignment and operation of the FEI Centre for Advanced Imaging(electron optics including transmission electron microscopy, Environmental scanning electron microscopy, Cryofocused ion beam microscopy). He liaises closely with FEI field engineers and customer support in fault diagnosisand repair. Development and optimisation of cryo dual beam microscopy for biological samples is the main thrust ofhis work and is ongoing. This includes developing protocols for sample preparation and imaging parameters for bothambient and cryogenic conditions, and have working ‘recipes’ for chemically fixed and unfixed cellular monolayers,resin embedded material and cryo-fractured samples.24
He has trained a large number of other users in the use of optical and electron microscopy to the point where theyare capable of using the instrumentation unsupervised or with minimal supervision.Dr O’Hagan’s first doctoral research student has recently finished her program of work and is awaiting a viva vocein the near future.Project collaborations:In addition to the ongoing development of biological cryo dual beam microscopy, Dr O’Hagan has been closelyinvolved in a number of other research projects within Ulster University, as well as collaborations with externalcompanies and institutions. These include the following:• Transmission electron microscopy of Nanotube structure (NI Bioengineering Centre - NIBEC).• Cryo-Dualbeam microscopy of osteoblast response to nanogrooved substrates. (University Nijmegen MedicalCentre, joint publication pending).• FIB nano-machining of AFM probe tips (Yael Dror, Oxford).• Cryo FIB, variable pressure ESEM Mitochondrial imaging. (University of Leicester, joint publication pending).• Temperature variation in SEM chamber during cryo operation (NIBEC).• TEM polymer structure and formation (Chemistry at Queens University).• Assistance with Nanotoxicology research (NanoInteract).• Assistance with fat emulsion research (CAST award with Unilever Research, Vlaardigan).• Assistance with investigations into bacterial adhesion to cells (CAST award with Unilever Research, PortSunlight).• Preliminary imaging of oil bearing rock core samples. (collaboration with Corex).Fig. 1Cryo Dual beam cross section through malariainfected bloodFig. 2Deconvolved multi-fluorescence image ofmammalian cell25
Page 1: BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5: 1 Foreword by the Pro Vice-Chancell
Page 6 and 7: 2 Foreword by the Research Institut
Page 8 and 9: The BMSRI Research StructureThe BMS
Page 10 and 11: BMSRI Core FacilitiesContact: Karen
Page 12 and 13: of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77:
Dr Barnes has developed expertise i
Page 78 and 79:
Dr Alison GallagherSenior Lecturer
Page 80 and 81:
In addition, results of a pilot stu
Page 82 and 83:
Dr Maeve KerrResearch AssociateCont
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Memberships of External Committees/
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Indicators of Esteem:Professor McNu
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were examined. The intervention and
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Within this work both short-term an
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micronutrient supplementation at a
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10. STEM CELL & EPIGENETICS RESEARC
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Publications:Lees-Murdock DJ, Lau H
Page 98 and 99:
Publications:Lees-Murdock DJ, Lau H
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11. SYSTEMS BIOLOGY RESEARCH GROUPT
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Kravtsov V, Swain M, Schuster A, Du
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Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107:
Zhang et al; Incorporating Feature
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Bala P, Baldridge K, Benfenati E, C
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In addition there is a growing them
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Clinical work involves development
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In 2009 he was appointed Chairman o
Page 116 and 117:
Stevenson TR, Goodall EA and Moore
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Dr Raymond BeirneLecturer in Optome
Page 120 and 121:
Dr Julie McClellandLecturer in Opto
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Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
Page 136 and 137:
Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
Page 140 and 141:
Student: Clare RyanTitle: How does
Page 142 and 143:
CONGRATULATIONS TO THE FOLLOWING PO
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