biomedical sciences research institute - Research - University of Ulster

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Dr Barnes has developed expertise in conducting human intervention studies and specialised laboratory techniques,particularly those associated with vitamin D metabolism and immune function. Her work has also focused on dietaryassessment, body composition and bone mineral density measurements.Other research interests include the effect of vitamin D status on immune conditions, particularly multiple sclerosis,vitamin D requirements during pregnancy and the influence of body composition on nutrient status.Dr Barnes is a Member of: The Nutrition Society, UK; the Multiple Sclerosis Society, UK; the Ulster ImmunologyGroup; and the Institute of Biomedical Science (Licentiate)Press releases:http://news.ulster.ac.uk/releases/2008/4014.htmlhttp://news.ulster.ac.uk/releases/2007/3543.htmlPublications:KD Cashman, TR Hill, AJ Lucey, N Taylor, KM Seamans, S Muldowney, AP FitzGerald, A Flynn, MS Barnes, G Horigan,MP Bonham, EM Duffy, JJ Strain, JMW Wallace & M Kiely; Estimation of the dietary requirement for Vitamin D inhealthy adults; American Journal of Clinical Nutrition, 88: 1535-1542, 2008MS Barnes, MP Bonham, PJ Robson, JJ Strain, AS Lowe-Strong, J Eaton-Evans, F Ginty & JMW Wallace; Assessment of25-hydroxyvitamin D and 1,25-dihydroxyvitamin D 3levels in male and female multiple sclerosis patients and healthycontrols; Multiple Sclerosis, 13: 670-672, 2007Dr Emeir DuffyLecturer in Human NutritionContact Details:T: +44 (0)28 70323543em.duffy@ulster.ac.ukDr Emeir Duffy’s main research interests include the effect of diet, specifically omega-3 fatty acids and vitamin D, onhealth and autoimmune diseases. She also has an interest in marine derived functional foods. During this reportingperiod Dr Duffy was a member of Seychelles Child Development Nutrition Research Group where she was activelyinvolved in the EU 6 th Framework funded project ‘PHIME’ investigating methyl mercury (MeHg) toxicity duringpregnancy. The PHIME consortium consists of 31 partners in 20 countries and will run over five years (2006-2011).In Europe and worldwide there is great speculation as to the effect of toxic metals, in particular MeHg, on childneurodevelopment. Results from these projects will provide information and guidance referring to health impactsassociated with consuming foodstuffs contaminated with toxic metals.Dr Duffy was a member of the vitamin D research group where she was actively involved in the Food Standards Agencyfunded projects ‘An investigation of the relative significance of both dietary sources and sunlight on vitamin D statusand/or functional markers, with particular emphasis on provision of scientific basis for dietary recommendations’ and‘Vitamin D status and associated health outcomes’. The results of the first study have been published and the secondstudy is still ongoing. Vitamin D deficiency is a major public health challenge facing the world and results from thesestudies will impact on public health strategies aimed at targeting this problem.In 2007, Dr Duffy formed partnership with 6 other institutions on the Island of Ireland to form the Marine FunctionalFoods Research Initiative Consortium of which she acts as the PI for the University of Ulster. This initiative is toestablish Ireland as a world-competitor in the area of marine functional foods and identify novel marine derived74
ioactives by enabling technological transfer between academia and industry. To further establish links with the Marineindustry and UU she was successful in being awarded a Fusion project and an Enterprise Ireland funded project toinvestiate the effect of a marine derived calcium supplement on bone health. Median term deliverables include theidentification of dietary compounds that demonstrate anti-cancer activity in vitro together with identifying beneficialeffects of marine-derived compounds on cancer and bone health with potential applications in functional foods.Dr Duffy was involved in a project funded by CAST, in conjunction with the LMC Northern Ireland, investigating theeffect of grass feeding on the omega-3 content of red meat produced in Northern Ireland. Medium term deliverablesinclude the identification of grass-finished red meat as a valuable source of dietary omega-3 bringing added valueto Northern Irish produced beef and lamb. Dr Duffy was actively involved in the Lupus Research Group NorthernIreland and a committee member of the Ulster Immunology Group (UIG). Awarded a DEL funded PhD to furtherinvestiate the effect of vitamin D on systemic lupus erythematosus. In October 2007, she formed part of the localorganising committee for the British Society of Immunology (BSI) 50 th Anniversary Symposium hosted by the UIG inBelfast.Publications:Bonham MP, Duffy EM, Robson PJ, Wallace JM, Myers GJ, Davidson PW, Clarkson TW, Shamlaye CF, Strain J, LivingstoneMB; Contribution of fish to intakes of micronutrients important for fetal development: a dietary survey of pregnantwomen in the Republic of Seychelles; Public Health Nutrition, 6: 1-9, 2008Bonham MP, Duffy EM, Wallace JM, Robson PJ, Myers GJ, Davidson PW, Clarkson TW, Shamlaye CF, Strain JJ; Habitual fishconsumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child DevelopmentNutrition Study); Prostaglandins Leukot Essent Fatty Acids, 78: 343-350, 2008Davidson PW, Strain JJ, Myers GJ, Thurston SW, Bonham MP, Shamlaye CF, Stokes-Riner A, Wallace JM, Robson PJ,Duffy EM, Georger LA, Sloane-Reeves J, Cernichiari E, Canfield RL, Cox C, Huang LS, Janciuras J, Clarkson TW;Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish duringpregnancy; Neurotoxicology, 29: 767-775, 2008Cashman KD, Hill TR, Lucey AJ, Taylor N, Seamans KM, Muldowney S, Fitzgerald AP, Flynn A, Barnes MS, Horigan G,Bonham MP, Duffy EM, Strain JJ, Wallace JM, Kiely M; Estimation of the dietary requirement for vitamin D in healthyadults; American Journal of Clinical Nutrition, 88: 1535-1542, 2008Strain JJ, Davidson PW, Bonham MP, Duffy EM, Stokes-Riner A, Thurston SW, Wallace JM, Robson PJ, Shamlaye CF,Georger LA, Sloane-Reeves J, Cernichiari E, Canfield RL, Cox C, Huang LS, Janciuras J, Myers GJ, Clarkson TW;Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in theSeychelles Child Development Nutrition Study; Neurotoxicology, 29: 776-782, 2008Wallace JM, Bonham MP, Strain J, Duffy EM, Robson PJ, Ward M, McNulty H, Davidson PW, Myers GJ, Shamlaye CF,Clarkson TW, Molloy AM, Scott JM, Ueland PM; Homocysteine concentration, related B vitamins, and betaine inpregnant women recruited to the Seychelles Child Development Study; American Journal of Clinical Nutrition, 87: 391-397, 2008Wright SA, O'Prey FM, McHenry MT, Leahey WJ, Devine AB, Duffy EM, Johnston DG, Finch MB, Bell AL, McVeigh GE.A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activityin systemic lupus erythematosus; Ann Rheum Dis, 67: 841-848, 200875
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
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BMSRI Academic Heads new Regional N
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4. BIOMEDICAL GENOMICS RESEARCH GRO
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Recent Funding Initiatives:C-TRIC:
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Dr Mateus Webba da SilvaLecturer in
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5. BIOIMAGING RESEARCH GROUPResearc
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developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
Page 96 and 97: Publications:Lees-Murdock DJ, Lau H
Page 98 and 99: Publications:Lees-Murdock DJ, Lau H
Page 100 and 101: 11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 102 and 103: Kravtsov V, Swain M, Schuster A, Du
Page 104 and 105: Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107: Zhang et al; Incorporating Feature
Page 108 and 109: Bala P, Baldridge K, Benfenati E, C
Page 110 and 111: In addition there is a growing them
Page 112 and 113: Clinical work involves development
Page 114 and 115: In 2009 he was appointed Chairman o
Page 116 and 117: Stevenson TR, Goodall EA and Moore
Page 118 and 119: Dr Raymond BeirneLecturer in Optome
Page 120 and 121: Dr Julie McClellandLecturer in Opto
Page 122 and 123: Graham JE, Moore JE, Moore JE, McCl
Page 124 and 125: Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
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Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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