Within this work both short-term and longer-term clinical trials are being used to evaluate the uptake and healthbenefits <strong>of</strong> these potentially bioactive wholegrain components. Of particular interest is the role and potential <strong>of</strong> themicronutrient betaine within the wholegrain. The structure <strong>of</strong> this project allows findings to be communicated tocereal producers / processors, aiding the production <strong>of</strong> foods rich in protective wholegrain components, as well ashealth pr<strong>of</strong>essionals, helping to support current European nutritional guidelines and health-claim legislation.As part <strong>of</strong> this work, Dr Price has developed expertise in conducting human intervention trials as well as inspecialised laboratory techniques determining clinical risk markers for health. Particular analysis <strong>of</strong> interest includesinflammation status, oxidative stress as well as micronutrient and phytochemical status. Her work has also involveddietary nutritional assessment as well as the determination <strong>of</strong> bone mineral density.Other <strong>research</strong> interests include the phenolic and antioxidant activity <strong>of</strong> foods including cereals and fruit juices, andDr Price has been involved with a project with Agri-Food & Bio<strong>sciences</strong> Institute (AFBI), Belfast, assessing the effects<strong>of</strong> processing on these parameters. In addition Dr Price continues to be involved in FUSION projects and mentorsstudents in the area <strong>of</strong> product development and functional foods.Dr Price is a Member <strong>of</strong> The Nutrition Society, UK.Publication:Price RK, Welch RW, Lee-Manion AM, Bradbury I, Strain JJ. Total phenolics and antioxidant potential in plasma andurine <strong>of</strong> humans after consumption <strong>of</strong> wheat bran; Cereal Chemistry, 18: 152-157, 2008Dr Barbara Stewart-KnoxSenior Lecturer in Biomedical SciencesContact Details:T: +44 (0)28 70324781b.knox@ulster.ac.ukDr Stewart-Knox has an interest in the following <strong>research</strong> themes:• Food choice, psycho-social and sensory determinants• Nutrient mediated psychological functions• Food product development related consumer issues• Attitudes toward infant feeding• Health promotion issues.However, Dr Stewart-Knox’s main <strong>research</strong> interest is the psycho-social aspects <strong>of</strong> food.NICHE conducts <strong>research</strong> into a range <strong>of</strong> food-related consumer issues and psychological functions using a range<strong>of</strong> methodologies both quantitative and qualitative in the following areas:• Pre- and post-launch food product evaluation• Determinants <strong>of</strong> food choice:Attitudes toward food related issuesSensory perceptions <strong>of</strong> food.• Investigation into food/nutrient mediated psychological functions:Affective88
CognitiveBehavioural.• Understanding health behaviour:Infant feedingSmoking.Publications:Simpson EE, McConville C, Rae G, O'Connor JM, Stewart-Knox BJ, Coudray C, Strain JJ; Salivary cortisol, stress andmood in healthy older adults: The Zenith study; Biological Psychology, 78: 1-9, 2008Stewart-Knox BJ, Bunting BP, Gilpin S, Parr HJ, Pinhão S, de Almeida MDV & Gibney M; Attitudes toward genetic testingand personalised nutrition in a representative sample <strong>of</strong> European consumers; British Journal <strong>of</strong> Nutrition [E-publicationcopy Ahead <strong>of</strong> print] (2008)Stewart-Knox BJ, Simpson EE, Parr H, Rae G, Polito A, Intorre F, Andriollo Sanchez M, Meunier N, O'Connor JM, MaianiG, Coudray C, Strain JJ; Taste acuity in response to zinc supplementation in older Europeans; British Journal <strong>of</strong> Nutrition,99:129-136, 2008Williams E, Stewart-Knox BJ, McConville C, Bradbury I, Armstrong N & McNulty H; Folate Status and Mood: Is Therea Relationship? Public Health Nutrition, 11: 118-123, 2008Dr Julie WallaceSenior <strong>Research</strong> FellowDr Wallace’s primary <strong>research</strong> focuses on modulation <strong>of</strong> immune function by diet and also the relationship betweenbody composition and immune function/inflammation.Alterations in immune function and inflammation are associated with the major diseases on the developed world,including cardiovascular disease, cancer and dementia. While it has been recognized for many years that deficiency<strong>of</strong> particular nutrients can lead to impaired immunity and susceptibility to infection, suboptimal status <strong>of</strong> nutrients,as is evident in the Western World can also lead to impaired immune function. NICHE conducts fundamental<strong>research</strong> assessing changes in immune function associated with normal physiological processes and also associatedwith pathological disease processes. The group also <strong>research</strong>es the complex relationship between specific nutrientsand immune function.In the last five years the group has carried out observational <strong>research</strong> and reported changes in immunological andhaemostatic function in pregnancy, which protect the mother and fetus from pregnancy complications. This <strong>research</strong>also highlighted the potential benefits for pregnant women in continuing folic acid supplementation throughoutpregnancy. <strong>Research</strong> has also shown that the immune system <strong>of</strong> men and women aged 55-70years shows differentassociations with age, with ageing <strong>of</strong> the immune system in women possibly delayed owing to the protective actions<strong>of</strong> the female hormones.The influence <strong>of</strong> specific micronutrients including omega-3 fatty acids, zinc, γ-tocopherol and vitamin D in modulatingimmune function is a particular interest <strong>of</strong> the <strong>research</strong> group and a number <strong>of</strong> studies have been undertaken andare currently being performed in this area. The intervention studies focus on a nutritional approach, providing89
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
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BMSRI Academic Heads new Regional N
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4. BIOMEDICAL GENOMICS RESEARCH GRO
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Recent Funding Initiatives:C-TRIC:
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Dr Mateus Webba da SilvaLecturer in
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5. BIOIMAGING RESEARCH GROUPResearc
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developmental alterations that mani
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Publications:Bigot S, Lucas L, Morr
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Publications:Barnes CA, O’Hagan B
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We also measure the genotoxic effec
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6. CANCER AND AGEING RESEARCH GROUP
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Professor Anthony P McHaleProfessor
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Professor Stephanie McKeownProfesso
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an Alzheimer Research Trust collabo
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO