Dr Julie McClellandLecturer in OptometryOngoing <strong>research</strong> during this reporting period has continued to investigate visual function in children with neurologicalimpairment (cerebral palsy). This <strong>research</strong>, which maintains collaborations with the Belfast Health and Social CareTrust, aims to improve the understanding <strong>of</strong> visual development in this population. A publication stemming from theCP <strong>research</strong> describes the use <strong>of</strong> a clinical tool to identify visual anomalies in this vulnerable group.Work describing the changing visual pr<strong>of</strong>ile over a 30-year period <strong>of</strong> children attending a school for those with visualimpairment in Northern Ireland was published during this period. It highlights the increasing numbers <strong>of</strong> childrenwith visual impairment and additional difficulties attending this specialist school and describes the changing origins <strong>of</strong>the visual impairment over the previous 30 years.A PhD examining visual function in a group <strong>of</strong> children with reading difficulties will provide novel data from aEuropean population and will strengthen collaborations with clinical optometrists in Europe.Data collection for an epidemiological study <strong>of</strong> refractive error in Northern Ireland school age children has recentlybeen completed. This study investigated the prevalence and degree <strong>of</strong> refractive anomalies and associated riskfactors in a UK population.Funding was secured for a study to investigate the incidence and nature <strong>of</strong> refractive anomalies in children withalbinism. This population-based study will describe the visual pr<strong>of</strong>ile <strong>of</strong> this particular group providing previouslyunavailable data. A PhD student has been recruited to the project.Publications:McClelland JF, Saunders KJ, Hill N, Magee A, Shannon M, Jackson AJ; The changing visual pr<strong>of</strong>ile <strong>of</strong> children attendinga regional specialist school for the visually impaired in Northern Ireland; Ophthalmic and Physiological Optics, 26: 556-560, 2007Saunders KJ, McClelland JF, Richardson PM, Stevenson M; Clinical Judgement <strong>of</strong> near pupil responses provides a usefulindicator <strong>of</strong> ocular accommodation (focusing ability) in children with cerebral palsy; Developmental Medicine and ChildNeurology, 50: 33-37, 2008Mr Johnny Moore, ConsultantOphthalmologistVisiting Pr<strong>of</strong>essorMr Johnny Moore, Visiting Pr<strong>of</strong>essor with <strong>University</strong> <strong>of</strong> <strong>Ulster</strong> works closely with other ocular immunology <strong>research</strong>erswithin the Centre for Molecular Bio<strong>sciences</strong>, which include: Dr Tara Moore, Senior Lecturer, Dr Jo Graham, Postdoctoral <strong>Research</strong> Associate, Dr Elena Novitskaya, Post doctoral <strong>Research</strong> Associate and Ophthalmologist, Dr VickyMcGilligan, Post doctoral <strong>Research</strong> Associate and Visiting Lecturer. Mr Moore facilitates and promotes translational118
patient based <strong>research</strong> within the laboratory. <strong>Research</strong> interests focus in particular on diagnostic and therapeuticapproaches for the ocular surfce.ggFigure 1: This method known as impression cytology provides a flat mount <strong>of</strong> cells with well-preserved morphology <strong>of</strong>ten usedfor further assessment via real time PCR for detection <strong>of</strong> viral antigen or bacterial DNA or immun<strong>of</strong>luorescent detection <strong>of</strong>viral antigen.The two common conditions which are investigated are Herpes Simplex Keratitis and Dry Eye. Herpes SimplexKeratitis (HSK) is a sight threatening ocular infection requiring a specific and prompt diagnosis which is caused byHerpes simplex virus type 1 (HSV-1). HSV-1 ocular infections are amongst the most common clinically encounteredinfections in ophthalmic practice. Correct diagnosis <strong>of</strong> HSK is critically important for appropriate patient managementand <strong>research</strong> within the group to date has focused on a fluorescein conjugated monoclonal antibody assay and nestedreal time PCR assay as diagnostic tools for HSK.Dry Eye <strong>research</strong> to date within the group has involved over 200 subjects and has investigated the microbiology <strong>of</strong>the ocular surface in terms <strong>of</strong> bacteria present and their impact on the cells <strong>of</strong> the ocular surface. Additional patientbased <strong>research</strong> includes: concordance between common dry eye diagnostic tests and attitudes towards diagnostictests and therapies for dry eye disease. All <strong>research</strong> efforts are within the area <strong>of</strong> personalised medicine for bothdiagnostics and therapeutic ocular pathology.External <strong>Research</strong> Grants (J Moore)Dr Tara Moore, Dr Victoria McGilligan, Pr<strong>of</strong> Jonathan Moore, POC: Ocular Surface, Diagnostic tool, Invest NorthernIreland, £73,707Dr Victoria McGilligan, Pr<strong>of</strong> Jonathan Moore, Dr Tara Moore, TRB Chemedica International SA, Dry Eye Trial,£25,000Dr Tara Moore, Dr Victoria McGilligan, Pr<strong>of</strong> Jonathan Moore, Efficacy <strong>of</strong> a point <strong>of</strong> care diagnostic test to rapidly andaccurately diagnose herpes simplex keratitis, HPSS <strong>Research</strong> and Development Office RRG, £48,676Publications:Graham JE, Moore JE, Jiru X, Moore JE, Goodall EA, Dooley JSG, Hayes V, Dartt DA, Downes SC & Moore CBT;Ocular Pathogen or Commensal: A PCR Based Study <strong>of</strong> Surface Bacterial Flora in Normal and Dry Eyes; InvestigativeOphthalmology & Visual Science, 48: 5616-5623, 2007Novitskaya ES, Dean SJ, Moore JE, Sharma A; A novel method to study fluorescein staining <strong>of</strong> the ocular surface usingthe fluorescein angiogram setting <strong>of</strong> the fundus camera; Cont Lens Anterior Eye, 30: 258-259, 2007Atkinson SD, Moore JE, Shah S, Sharma S, Best RM, Leccisotti A, Alarbi M, Rimmer D, Gardiner T, Moore CBT; P63expression in conjunctival proliferative diseases: pterygium and LOC syndrome; Current Eye <strong>Research</strong>, 33: 551-558,2008Dean SJ, Novitskaya ES, Moore CBT, Moore JE, Sharma A; Documentation <strong>of</strong> corneal epithelial defects withfluorescein enhanced digital fundus camera photography; Clinical and Experimental Ophthalmology, 36: 113-118, 2008119
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
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BMSRI Academic Heads new Regional N
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4. BIOMEDICAL GENOMICS RESEARCH GRO
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Recent Funding Initiatives:C-TRIC:
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Dr Mateus Webba da SilvaLecturer in
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5. BIOIMAGING RESEARCH GROUPResearc
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developmental alterations that mani
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Publications:Bigot S, Lucas L, Morr
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Publications:Barnes CA, O’Hagan B
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We also measure the genotoxic effec
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6. CANCER AND AGEING RESEARCH GROUP
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Professor Anthony P McHaleProfessor
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Professor Stephanie McKeownProfesso
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an Alzheimer Research Trust collabo
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JM, Waugh DJJ; Dexamethasone potent
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have wider applications in vivo, in
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Inter-relationships between diet an
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Flatt PR; Effective surgical treatm
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These areas are the subject of seve
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Dr YHA Abdel-WahabSenior Lecturer i
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Dr VA GaultLecturer in Molecular Bi
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McClean PL, Irwin N, Hunter K, Gaul
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Publications:Duffy NA, Green BD, Ir
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8. MICROBIOLOGY AND BIOTECHNOLOGYRE
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Publications:Graham RJL, Graham C,
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analyses. However there is still a
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Plessas S, Bekatorou A, Koutinas AA
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Biochemical studies/ viral evasion
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Dr Stephen McCleanLecturer in Prote
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