9. NORTHERN IRELAND CENTRE FOR FOODAND HEALTH (NICHE)Human nutrition <strong>research</strong> at the <strong>University</strong> <strong>of</strong> <strong>Ulster</strong> is centred in the Northern Ireland Centre for Food & Health(NICHE), a centre <strong>of</strong> excellence set up with EU structural funds in 1996 to provide greater understanding <strong>of</strong> dietrelatedhealth issues. NICHE has 20 academic, 5 technical and 9 <strong>research</strong> staff, as well as 29 postgraduate <strong>research</strong>students.<strong>Research</strong> is aimed at identifying food components or dietary regimes likely to lead to benefits for human health.An important aspect <strong>of</strong> our work is the development and validation <strong>of</strong> biomarkers for chronic disease to facilitatedietary intervention studies in healthy subjects at risk <strong>of</strong> disease.Human Nutrition <strong>research</strong> within NICHE was recently reviewed and reorganized under the following six <strong>research</strong>headings:• energy balance, appetite regulation and nutrition education;• folate and related B vitamins in health and disease;• phytochemicals and gut micr<strong>of</strong>lora in health and disease;• micronutrient modulation <strong>of</strong> immune and inflammatory responses;• nutrition toxicology and child development; and• psychological factors associated with food and nutrition.<strong>Research</strong> remains focused on human dietary interventions around the core <strong>research</strong> facility <strong>of</strong> the human interventionstudies unit. Although much <strong>of</strong> our <strong>research</strong> effort is focussed on studies in healthy humans, in recent years we haveextended our efforts to include <strong>research</strong> in specific patient groups through establishing collaborations with cliniciansin the specialised areas <strong>of</strong> cardiology, gastroenterology and paediatrics. Some, though not all, <strong>of</strong> this work includesmore dietetics related <strong>research</strong>, which is expected to have greater emphasis within NICHE in the longer term.Images <strong>of</strong> some <strong>of</strong> the facilities available in the Human Intervention Studies Unit (HISU),within the Centre for Molecular Bio<strong>sciences</strong>, <strong>University</strong> <strong>of</strong> <strong>Ulster</strong>70
Other core <strong>research</strong> facilities identified were those involved with the analysis <strong>of</strong> water-soluble vitamins, fattyacids and fat-soluble vitamins, trace elements and immune measures. Most other analysis would be outsourced tointernational centres <strong>of</strong> excellence including the Vitamin <strong>Research</strong> Laboratory, Trinity College Dublin and the MRCHuman Nutrition <strong>Research</strong>, Cambridge. <strong>Research</strong> funding opportunities will be mainly through a reactionary modeand opportunities will include the recent MRC’s Patient <strong>Research</strong> Cohorts Initiative Call. Proactive approaches willbe focused under the <strong>research</strong> areas identified above.In most cases it is anticipated that <strong>research</strong> outcomes will be <strong>of</strong> direct relevance to public health but fundamental<strong>research</strong> in vitro and in collaboration with those undertaking genomic and proteomic <strong>research</strong> will remain a feature.In particular, the <strong>University</strong>’s investment in a metabolomics facility under SRIF 3 will give exciting opportunities forbasic <strong>research</strong> in humans. <strong>Research</strong>ers within NICHE will continue to engage with the food industry in an effort toexploit potentially lucrative opportunities in relation to the functional food business and the health claims agenda. Itis anticipated that part <strong>of</strong> this portfolio <strong>of</strong> <strong>research</strong> will be applied <strong>research</strong> <strong>of</strong> direct relevance to the food industrywith consultancy encouraged and providing a stronger stance on intellectual property and commercialisation thanhitherto.MEMBERS OF THE GROUP:Pr<strong>of</strong>essor Sean StrainPr<strong>of</strong>essor <strong>of</strong> Human NutritionDirector <strong>of</strong> NICHEContact Details:T: +44 (0)28 70324795jj.strain@ulster.ac.ukAfter graduating with a BSc (Chemistry), BAgr (Agricultural Chemistry) and PhD (Nutritional Biochemistry), all fromQueen’s <strong>University</strong>, Pr<strong>of</strong>essor Sean Strain spent several years (1977-1980) in academia in Australia before joining the<strong>University</strong> <strong>of</strong> <strong>Ulster</strong> 1981. He is Pr<strong>of</strong>essor <strong>of</strong> Human Nutrition (since 1994) in the Northern Ireland Centre for Food& Health (NICHE). His <strong>research</strong> interests are mainly in the areas <strong>of</strong> nutrition and toxicology, trace element nutritionand in B-vitamin and homocysteine metabolism. The work on nutrition and toxicology involves collaboration with<strong>University</strong> <strong>of</strong> Rochester, New York and the Ministry <strong>of</strong> Health, Seychelles in a longitudinal observational motherchildcohort which is investigating associations between maternal exposure to nutrients, especially long-chainpolyunsaturated fatty acids (LCPUFA) and child development in the Republic <strong>of</strong> Seychelles where fish consumptionis high. Findings to date, support the potential importance to child development <strong>of</strong> n-3 LCPUFA present in fish and<strong>of</strong> LCPUFA in the overall diet and indicate that the beneficial effects <strong>of</strong> LCPUFA can outweigh the adverse effects <strong>of</strong>maternal methyl-mercury exposure. Work on B-vitamins and homocysteine metabolism is in collaboration with thegroup led by Pr<strong>of</strong>essor Helene McNulty.Pr<strong>of</strong>essor Strain is a member <strong>of</strong> various national and international committees including the Dietetic Products andNutrition Panel <strong>of</strong> the European Food Safety Authority, Parma and Chairs its Working Group on Health Claims;Food Strategy Implementation Partnership; MRC College <strong>of</strong> Experts; MRC Physiological Systems and Clinical SciencesSpecial Review Panel; Food Safety Promotions Board, Cork; Member <strong>of</strong> the Board <strong>of</strong> Directors, International LifeSciences Institute, Europe; Member <strong>of</strong> the Board <strong>of</strong> Governors <strong>of</strong> BBSRC Food <strong>Research</strong> Institute, Norwich;Chairman <strong>of</strong> the Board <strong>of</strong> European Nutrition Leadership Programme.Invited Lectures9-13 June 2008: EURECCA Annual Meeting, Montenegro5 June 2008: Health Claims Meeting, Health & Wellbeing, Special Interest Group, London13-15 May 2008: Second International Seafood & health Meeting, Bergen25-29 March 2008: Organised Workshop and gave opening talk, PHIME Meeting, Prague5 March 2008: Chair, Dairy Council Conference, Belfast8 November 2007: Colloquium on Nutrient Pr<strong>of</strong>iling, FIN, Paris71
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BIOMEDICAL SCIENCESRESEARCH INSTITU
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1 Foreword by the Pro Vice-Chancell
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2 Foreword by the Research Institut
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The BMSRI Research StructureThe BMS
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BMSRI Core FacilitiesContact: Karen
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of Metabolomics, pharmacy, nutritio
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BMSRI Academic Heads new Regional N
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4. BIOMEDICAL GENOMICS RESEARCH GRO
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Recent Funding Initiatives:C-TRIC:
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Dr Mateus Webba da SilvaLecturer in
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Graham JE, Moore JE, Moore JE, McCl
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Dr Victoria McGilliganResearch Asso
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Grant Holder Anderson, Prof RSFundi
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Student: Simon GenglerTitle: Effect
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CONGRATULATIONS TO THE FOLLOWING PO