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Flatt PR; Effective surgical treatment of obesity may be mediated by ablation of the lipogenic gut hormone gastricinhibitory polypeptide (GIP): Evidence and clinical opportunity for development of new obesity-diabetes drugs?;Diab. Vasc. Dis. Res., 4: 151-153, 2007Irwin N, Hunter K and Flatt PR; Comparison of the sub-chronic metabolic effects of GIP receptor antagonism andPYY(3-36) receptor activation in high fat fed mice; Peptides, 28: 2192-2198, 2007Kiely A, McClenaghan NH, Flatt PR and Newsholme P; Pro-inflammatory cytokines increase glucose, alanineand triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line; Journal ofEndocrinology, 195: 113-123, 2007Liu HK, McCluskey JT, McClenaghan NH and Flatt PR; Streptozotocin-resistant BRIN-BD11 cells possess wide spectrumof toxin tolerance and enhanced insulin-secretory capacity; Endocrine, 32: 20-29, 2007McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA and Flatt PR; GIP receptor antagonism using (Pro 3 )GIP reverses obesity,insulin resistance and associated metabolic disturbances induced in mice by prolonged consumption of high fat diet;American Journal of Physiology, 293: E1746-1755, 2007Abdel-Wahab YHA, Power GJ, Ng MT, Flatt PR and Conlon MJ; Insulin-releasing properties of the frog skinpeptide pseudin-2 and its [Lys18]-substituted analogue; Biol. Chem., 389: 143-148, 2008Abdel-Wahab YHA, Power GJ, Flatt PR, Woodhams DC, Rollins-Smith LA and Conlon JM; A peptideof thephylloeptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and invivo insulin-releasing activity; Peptides, 29: 2136-2143, 2008Cassidy RS, Irwin N and Flatt PR; Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon releaseat normo- and hyperglycaemia in Wistar rats and isolated islets; Biol. Chem., 389: 189-193, 2008Conlon JM, Power GJ, Abdel-Wahab YHA, Flatt PR, Jiansheng H, Coquet L, Leprince J, Jouenne T and VaudryH; A potent non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog,Hylarana guntheri (Anura: Ranidae); Regulatory Peptides, 151: 153-159, 2008Gault VA, Kerr BD, Irwin N and Flatt PR; C-terminal mini-PEGylation of glucose-dependent insulinotropicpolypeptide exhibits metabolic stability and improved glucose homeostasis in ietary-induced diabetes;Biochem. Pharmacol. 75: 2325-2333; 2008.Irwin N, Hunter K and Flatt PR; Comparison of independent and combined metabolic effects of GIP andCB1 receptor blockade in high-fat fed mice; Peptides, 29: 1036-1041, 2008Irwin N, Hunter K, Frizzell N and Flatt PR; Antidiabetic effects of sub-chronic administration of the cannabinoidreceptor (CB1) antagonist, AM251, in obese diabetic (ob/ob) mice; European Journal of Pharmacology, 581:226-233, 2008Liu HK, McCluskey JT, McClenaghan NH and Flatt PR; Interative exposure of clonal BRIN-BD11 cellsto ninhydrin enables selection of robust toxin-resistant pancreatic beta cells but with decreased geneexpression and insulin-secretory function; Pancreas, 36: 294-301, 2008McClean PL, Irwin N, Hunter K, Gault VA and Flatt PR; (Pro 3 )GIP[mPEG]: Novel long-acting mini-PEGylatedgastric inhibitory polypeptide antagonist for obesity-diabetes therapy; British Journal of Pharmacology, 155:690-701, 2008McKillop AM, Duffy NA, Lindsay JR, O’Harte FPM, Bell P and Flatt PR; Decreased dipeptidyl peptidase IVactivity and GLP-1 degradation in type 2 diabetic subjects; Diabetes Clin. Res. Pract, 79: 79-85, 200844
Taylor A, Irwin N, McKillop AM, Flatt PR and Gault VA; Sub-chronic administration of 11beta-HSD1 inhibitor,carbenoxolone, improves glucose tolerance and insulin insensitivity in mice with diet-induced obesity; Biol.Chem., 389: 441-445, 2008Irwin N, McClean PL, Hunter K & Flatt PR (2009) Metabolic effects of sustained activation of the GLP-1 receptoralone and in combination with background GIP receptor antagonism in high fat fed mice. Diabetes, Obesity and Metabolism(in press)Irwin N, Hunter K, Frizzell N and Flatt PR; Antidiabetic effects of sub-chronic up-regulation of the GIP receptor aloneand in combination with background exendin-4 therapy in high fat fed mice; Reg. Pept. (in press)Kerr BD, Irwin N, Flatt PR and Gault VA; Prolonged GIP receptor activation using stable mini-PEGylated GIP improvesglucose homeostasis and beta cell function in age-related glucose intolerance; Peptides (in press)McClenaghan NH, Scullion SM, Mion N, Hewage C, Malthouse JPG, Flatt PR, Newsholme P and Brennan L; Prolongedalanine exposure induces changes inmetabolism, Ca 2+ handling and desensitization of insulin secretion in clonalpancreatic beta cells; Clin. Sci. (in press)Professor FPM O’HarteProfessor of Endocrinology & MetabolismContact details:T: +44 (0)28 70324853fpm.oharte@ulster.ac.ukBrief profile:BSc Hons and PhD from Queen’s University Belfast. Research Fellow at Creighton University, Omaha, USA (1989-91),University College Cork (1992-93) and University of Ulster (1993-95) before taking up an academic appointmentat the University of Ulster in 1995. Promoted to Reader in 2000 and Professor of Endocrinology and Metabolismin 2005. Patent holder and academic co-founder of Diabetica Limted, a UU start-up company focused on innovativediabetes therapeutics. Over 180 peer-reviewed publications with many presentations at national and internationalconferences and was recipient of the Nordisk Medal of the Irish Endocrine Society (2005).Main Research interests:• structurally modified peptides in therapy and drug development• role of regulatory peptides in control of feeding and obesity• incretin hormone analogues in diabetes therapy• structure-function activity of peptides• hormone receptor modelling and NMR• glucagon receptor antagonists in diabetes therapy.Professor O’Harte’s main research interests include investigations into the impact of structural modification ofbiologically active brain-gut peptides on the regulation of feeding, pancreatic beta cell function and anti-hyperglycaemicactivity. This work has focused in the synthesis of a numerous novel biologically active and enzyme-resistant long-actingpeptide analogues for potential obesity-diabetes therapy. Modifications of the antidiabetic incretin hormones GLP-1and GIP as well as the anti-obesity hormone CCK-8 leading to enhanced biological action of these agents formedthe main focus of this work. However, preliminary work was also performed to assess the potential of peptide-basedglucagon receptor antagonists as novel antidiabetic agents. Pre-clinical investigations are at an advanced stage withthe GIP based agents.45
Page 1: BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5: 1 Foreword by the Pro Vice-Chancell
Page 6 and 7: 2 Foreword by the Research Institut
Page 8 and 9: The BMSRI Research StructureThe BMS
Page 10 and 11: BMSRI Core FacilitiesContact: Karen
Page 12 and 13: of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 48 and 49: These areas are the subject of seve
Page 50 and 51: Dr YHA Abdel-WahabSenior Lecturer i
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
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Publications:Lees-Murdock DJ, Lau H
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Publications:Lees-Murdock DJ, Lau H
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11. SYSTEMS BIOLOGY RESEARCH GROUPT
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Kravtsov V, Swain M, Schuster A, Du
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Dr Daniel BerrarLecturer in Biomedi
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Zhang et al; Incorporating Feature
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Bala P, Baldridge K, Benfenati E, C
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In addition there is a growing them
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Clinical work involves development
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In 2009 he was appointed Chairman o
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Stevenson TR, Goodall EA and Moore
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Dr Raymond BeirneLecturer in Optome
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Dr Julie McClellandLecturer in Opto
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Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
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Dr Victoria McGilliganResearch Asso
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13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
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Student: Simon GenglerTitle: Effect
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Student: Anisha MazumdarTitle: Anal
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Student: Clare RyanTitle: How does
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CONGRATULATIONS TO THE FOLLOWING PO
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