biomedical sciences research institute - Research - University of Ulster

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Dr YHA Abdel-WahabSenior Lecturer in Biomedical SciencesContact details:+44 (0)28 70324354y.abdel-wahab@ulster.ac.ukBrief profile:MB. BCh. (1985), Faculty of Medicine, Cairo University, Egypt and PhD (1993) from University of Ulster,Coleraine. Postdoctoral Research Fellow at Creighton University, School of Medicine, USA (1994-95),Postdoctoral Researcher at the University of Ulster at Coleraine (1995-2007) before taking up current appointmentas Senior Lecturer in Biomedical Sciences at the University of Ulster in 2007. Dr Abdel-Wahabhas over 60 peer-reviewed publications, invited speaker at many national and international conferences andis a Patent holder.Main research interests:Discovery, targets and action of antidiabetic drugs from natural resourcesAntidiabetic actions of structurally modified peptidesGlycation of pancreatic islet peptides and proteinsStem cell and gene therapy in diabetes.Publications:Abdel-Wahab YHA, Maranah L, Flatt PR, Conlon JM; Insulin releasing properties of the temporin family of antimicrobialpeptides; Europe Protein & Peptide Letters, 14: 702-707, 2007Hannan JMA, Marenah L, Ali L, Rokeya B, Flatt PR and Abdel-Wahab YHA; Insulin secretory actions of extracts ofAsparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic B-cells; Journal of Endocrinology,192: 159-168, 2007Hannan JMA, Ali L, Rokeya B, Khaleque J, Akhter M, Flatt PR and Abdel-Wahab YHA; Soluble dietary fibre fraction ofTrigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in type 1 and type 2 diabetes by delayingcarbohydrate digestion, absorption and enhancing insulin action; British Journal of Nutrition, 97: 514-521, 2007Abdel-Wahab YHA, Power GJ, Ng MT, Flatt PR, Conlon JM; Insulin-releasing properties of the frog skin peptidepseudin-2 and its [Lys 18 ] substituted analogue; Biological Chemistry, 389: 143-148, 2008Abdel-Wahab YHA, Power GJ, Flatt PR, Woodhams DC, Rollins-Smith LA, Conlon JM; A peptide of thephylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and invivo insulin-releasing activity; Peptides, 29: 2136-2143, 2008Conlon JM, Power GJ, Abdel-Wahab YHA, Flatt PR, Jiansheng H, Coquet L, Leprince J, Jouenne T, Vaudry H; Apotent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana güntheri(Anura:Ranidae); Regulatory peptides, 151: 153-159, 2008Conlon JM, Abdel-Wahab YHA, Flatt PR, Leprince J; A glycine-leucine-rich peptide structurally related to the plasticinsfrom skin secretions of the frog Leptodactylus laticeps (Leptodactylidae); Peptides (in press)48
Dr AM McKillopSenior Lecturer in Clinical & Endocrine BiochemistryContact Details:T: +44 (0)28 70323066am.mckillop@ulster.ac.ukBrief profile:BSc Hons and PhD from Queen’s University, Belfast and MSc from the University of Ulster. PostdoctoralResearch Fellow at Queen’s University, Belfast (1996-98) and the University of Ulster at Coleraine (1998-02) before taking up current appointment as Lecturer in Clinical Biochemistry at the University of Ulster in2002. Patent holder and over 40 peer-reviewed publications and presentations at national and internationalconferences.Main research interests:• clinical biochemistry and diabetes proteomics• cellular glucose handling and metabolism• pancreatic beta-cell peptides and proteins• mechanisms of insulin resistance and diabetes pathogenesis• glycation of insulin and other key regulatory proteins• structural and functional characterization of novel biomolecules• insulin receptor dysfunction and novel treatments for diabetes.During the year under review, Dr McKillop obtained a pilot grant (£10,000) from the University “Pre-Proof ofConcept Scheme” to support a recently successful application to Invest Northern Ireland for a Proof of Conceptgrant (£70,340) to investigate: “Intestinal Biomarkers for Diabetes”.Publications:Duffy N, Green BD, Irwin N, Gault VA, McKillop AM, O’Harte FPM, Flatt PR; Effects of antidiabetic drugs in dipeptidylpeptidase IV: Nateglinide is an inhibitor of DPPIV and augments antidiabetic activity of glucagon-like peptide-1;European Journal of Pharmacology, 568: 278-286, 2007McKillop AM, Duffy NA, Lindsay JR, O’Harte FPM, Bell PM, Flatt PR; Decreased dipeptidyl peptidase-IV activity andglucagon-like peptide-1(7-36)amide degradation in type 2 diabetic subjects; Diabetes Res Clin Pract., 79: 79-85, 2008McKillop, AM., Flatt PR; Recent Developments in the Search for Biomarkers for the Diagnosis and Monitoring ofDiabetes; Recent Patents on Endocrine, Metabolic & Immune Drug Discovery, 2: 172-177, 2008Taylor A, Irwin N, McKillop AM, Flatt PR, Gault VA; Sub-chronic administration of 11beta-HSD1 inhibitor, carbenoxolone,improves glucose tolerance and insulin sensitivity in mice with diet-induced obesity; Biological Chemistry, 389: 441-445,200849
Page 1: BIOMEDICAL SCIENCESRESEARCH INSTITU
Page 4 and 5: 1 Foreword by the Pro Vice-Chancell
Page 6 and 7: 2 Foreword by the Research Institut
Page 8 and 9: The BMSRI Research StructureThe BMS
Page 10 and 11: BMSRI Core FacilitiesContact: Karen
Page 12 and 13: of Metabolomics, pharmacy, nutritio
Page 14 and 15: BMSRI Academic Heads new Regional N
Page 16 and 17: 4. BIOMEDICAL GENOMICS RESEARCH GRO
Page 18 and 19: Recent Funding Initiatives:C-TRIC:
Page 20 and 21: Dr Mateus Webba da SilvaLecturer in
Page 22 and 23: 5. BIOIMAGING RESEARCH GROUPResearc
Page 24 and 25: developmental alterations that mani
Page 26 and 27: Publications:Bigot S, Lucas L, Morr
Page 28 and 29: Publications:Barnes CA, O’Hagan B
Page 30 and 31: We also measure the genotoxic effec
Page 32 and 33: 6. CANCER AND AGEING RESEARCH GROUP
Page 34 and 35: Professor Anthony P McHaleProfessor
Page 36 and 37: Professor Stephanie McKeownProfesso
Page 38 and 39: an Alzheimer Research Trust collabo
Page 40 and 41: JM, Waugh DJJ; Dexamethasone potent
Page 42 and 43: have wider applications in vivo, in
Page 44 and 45: Inter-relationships between diet an
Page 46 and 47: Flatt PR; Effective surgical treatm
Page 48 and 49: These areas are the subject of seve
Page 52 and 53: Dr VA GaultLecturer in Molecular Bi
Page 54 and 55: McClean PL, Irwin N, Hunter K, Gaul
Page 56 and 57: Publications:Duffy NA, Green BD, Ir
Page 58 and 59: 8. MICROBIOLOGY AND BIOTECHNOLOGYRE
Page 60 and 61: Publications:Graham RJL, Graham C,
Page 62 and 63: analyses. However there is still a
Page 64 and 65: Plessas S, Bekatorou A, Koutinas AA
Page 66 and 67: Biochemical studies/ viral evasion
Page 68 and 69: Dr Stephen McCleanLecturer in Prote
Page 70 and 71: environmental remediation and as ro
Page 72 and 73: 9. NORTHERN IRELAND CENTRE FOR FOOD
Page 74 and 75: 26-28 Sept 2007: International Seaf
Page 76 and 77: Dr Barnes has developed expertise i
Page 78 and 79: Dr Alison GallagherSenior Lecturer
Page 80 and 81: In addition, results of a pilot stu
Page 82 and 83: Dr Maeve KerrResearch AssociateCont
Page 84 and 85: Memberships of External Committees/
Page 86 and 87: Indicators of Esteem:Professor McNu
Page 88 and 89: were examined. The intervention and
Page 90 and 91: Within this work both short-term an
Page 92 and 93: micronutrient supplementation at a
Page 94 and 95: 10. STEM CELL & EPIGENETICS RESEARC
Page 96 and 97: Publications:Lees-Murdock DJ, Lau H
Page 98 and 99: Publications:Lees-Murdock DJ, Lau H
Page 100 and 101:
11. SYSTEMS BIOLOGY RESEARCH GROUPT
Page 102 and 103:
Kravtsov V, Swain M, Schuster A, Du
Page 104 and 105:
Dr Daniel BerrarLecturer in Biomedi
Page 106 and 107:
Zhang et al; Incorporating Feature
Page 108 and 109:
Bala P, Baldridge K, Benfenati E, C
Page 110 and 111:
In addition there is a growing them
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Clinical work involves development
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In 2009 he was appointed Chairman o
Page 116 and 117:
Stevenson TR, Goodall EA and Moore
Page 118 and 119:
Dr Raymond BeirneLecturer in Optome
Page 120 and 121:
Dr Julie McClellandLecturer in Opto
Page 122 and 123:
Graham JE, Moore JE, Moore JE, McCl
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Research Staff:Dr David OrrSenior R
Page 126 and 127:
Dr Victoria McGilliganResearch Asso
Page 128 and 129:
13. Externally Funded Projects duri
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Grant Holder Anderson, Prof RSFundi
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Funding Body Royal Irish AcademyAmo
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14. BIOMEDICAL SCIENCES RESEARCH IN
Page 136 and 137:
Student: Simon GenglerTitle: Effect
Page 138 and 139:
Student: Anisha MazumdarTitle: Anal
Page 140 and 141:
Student: Clare RyanTitle: How does
Page 142 and 143:
CONGRATULATIONS TO THE FOLLOWING PO
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