biomedical sciences research institute - Research - University of Ulster

Publication:Chang CK, Tseng KC, Lai NS, and Chou AL; Prognostic factors of chronic hepatitis C patients treated by pegylatedinterferon-alfa plus Ribavirin in Taiwan; American Journal of Epidemiology, 167: S73, 2008Dr Kurt SaetzlerLecturer in Computational BiologyContact details:T: +44 (0)28 70324021k.saetzler@ulster.ac.ukDr Kurt Saetzler’s main research interest is in spatial modelling of biological systems and digital image processing.Below find a list of projects and international project partners with whom he is networking and cooperating with:Spatial Systems Biology: coordinator of a COST network application involving several sites across Europe.3-D reconstructions from synaptic morphologies using serial electron-microscopical ultrathin sections: this is in collaborationwith: Professor Bert Sakmann (Max Planck Institute for Neurobiology, Munich), Michael Frotscher (University ofFreiburg), Joachim Luebke (Research Centre Juelich), Dr Arnd Roth and Professor Michael Haeusser (UCL). Thiswork also involves the coordination and development as part of the OpenCAR reconstruction project (opencar.ulster.ac.uk).Spatio-temporal simulations of synaptic transmission: a European network interested in the simulation of synaptictransmission has been formed (Professor Michael Haeusser, Dr Arnd Roth (UCL), Professor Jean-Daniel Boissonnatand Dr Mariette Yvinec (INRIA), Professor Peter Bastian, Dr Stefan Lang (University of Stuttgart), Dr MarkusKirkilionis (Warwick)). A European grant application is still pending.Tracing of stained neurons in SBFSEM series: novel algorithms have been developed as part of a collaboration with theMax Planck Institute for Medical Research in Heidelberg (Professors Winfried Denk and Bert Sakmann and Dr RandyBruno).The overarching topic, systems biology, which tries to integrate in-vivo and/or in-vitro experiments with in-silicomathematical models is at the core of the Life Science Interface between the BBSRC and the EPSRC in the UK. It isalso seen as strategically important to increase the competitiveness of European Science world- wide.Abstracts for conference presentations/posters:Rollenhagen et al. Structural determinants of transmission and plasticity of input synapses on layer 5 pyramidalneurons. Neuroscience Meeting 2007, Abstract and Slide Presentation, Session Number 656.3.Frotscher et al. Fine structure of mossy fiber synapses in the hippocampus revealed by high pressure freezing andfreeze substitution. Neuroscience Meeting 2007, Abstract and Slide Presentation, Session Number 656.7.Saetzler et al. The effects of non-rigid alignments on 3d reconstructions and quantitative measurements in largeseries of electron microscopical ultra-thin sections. Neuroscience Meeting 2007, Abstract, Session Number 104.23/BBB22.Publications:Morrow P and Saetzler K; Validation of in vivo Leukocyte Velocity Estimates via Modeling and Simulation; ConferenceRecord of the Forty-First Asilomar Conference on Signals, Systems and Computers, ACSSC 2007, 1288-1292, 2007Rollenhagen et al. Structural Determinants of Transmission at Large Hippocampal Mossy Fiber Synapses; Journal ofNeuroscience, 27: 10434-10444, 2007103