biomedical sciences research institute - Research - University of Ulster

MEMBERS OF THE GROUP:Academic StaffProfessor Barbara Pierscionek, Group LeaderProfessor of Optometry & Vision ScienceContact details:T: +44 (0)28 70323293b.pierscionek@ulster.ac.ukProfessor Pierscionek works on the all aspects of the anterior eye involving a range of biochemical and biophysicalmethods.The optics of the lens and cornea have been studied using ray tracing and mathematical analysis (Eikonal equation) todetermine the refractive indices of these elements and how these varies across species and with age and development.The optics of the eye is dependent on its rheological (biomechanical properties) and Professor Pierscionek, incollaboration with Dr Widlicka from the Wroclaw University of Technology have developed a means of measuringthe elastic properties of the cornea and sclera in an intact eyeball. Elasticity of the lens is being modelled using FiniteElement Analysis and based on experimental results from simulations of lens shape change (as it occurs in the eye).The link between optics and mechanics of the eye and how these alter with age, disease and surgery is a new field ofresearch which will be increasingly important as a national and international priority given the ageing population andthe growing demand for refractive surgery.Finite element lens:The functional (optical and mechanical) features are being studied in parallel with structural investigations of lensprotein distributions and how these change with growth and ageing in a variety of species. This work has resulted inestablishing collaborations with Professor Michael Dunn and Dr Giuliano Elia from the Conway Institute in Dublin.The biochemical work also involves cell culture and investigations of the viability of DNA and chromosomal damagein response to chemical agents and quantum dots. This work is conducted in collaboration with Dr Wei Chen fromthe University of Texas in Arlington and with Dr Ronald Schachar from Pfizer. It will also involve collaborations withProfessors McLaughlin and Meenan from the Nanotechnology Research Institute. This work is aimed at having afuture impact on better understanding the structure/function relationships of the anterior eye structures and howthese alter with age and disease.Cell CulturesIn addition, Professor Pierscionek is investigating iris biometry in collaboration with Professor Scotney and Dr Morrowfrom Computing and Engineering to design improved methods of identification. This addresses the internationalpriority in the biometrics as applied to issues of security, both national and international.109