2006 - UZ Leuven

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were 77%, 92%, and 83%, respectively. These parameters forremediastinoscopy were 29%, 100%, and 60%, respectively.Sensitivity (P < .0001) and accuracy (P = .012) were significantlybetter for PET-CT.Conclusion: After a thorough staging mediastinoscopy, postinductionremediastinoscopy had a disappointing sensitivity because ofadhesions and fibrosis. Integrated PET-CT yielded a better result thanthat obtained in previous studies with side-by-side PET and CTimages.DE LEYN P., VANSTEENKISTE J., NACKAERTS K., LORENT N., LIEVENSY., NAFTEUX P., VAN RAEMDONCK D., COOSEMANS W., DECKER G.,LERUT T.: Inductietherapie voor lokaal gevorderd niet-kleincelligbronchuscarcinoom: ervaring van de Leuven lung cancer group.Tijdschr. voor Geneeskunde, 2006; 62(7): 509-515.Bij het lokaal uitgebreide niet-kleincellige bronchuscarcinoom(wanneer er aantasting is van mediastinale lymfeklieren of bij zeercentraal gelegen tumoren of tumoren van de sulcus superior) zijn deresultaten van primaire heelkunde niet bemoedigend. Zowel de kansop complete resectie als de verwachte 5-jaarsoverleving zijn laag.Inductietherapie, bij middel van hetzij chemotherapie, hetzijchemoradiotherapie, biedt hier nieuwe perspectieven. In de groep vanpatiënten met aangetaste mediastinale klieren (N2-aantasting) die eenresectie ondergingen, bedroeg de 2-jaars en de 5-jaars overleving nainductietherapie respectievelijk 68 en 33%. Vooral patiënten metrespons in de mediastinale lymfeklieren hebben de beste prognose.PET-scan lijkt veelbelovend te zijn om deze respons te meten. BijPancoasttumoren is inductieradiochemotherapie gevolgd doorresectie de nieuwe standaardbehandeling.In dit kort artikel rapporteren we de ervaring vaninductiechemotherapie en inductiechemotherapie met radiotherapievan de Leuven Lung Cancer Group.DRIESSEN A., LANDUYT W., PASTOREKOVA S., MOONS J., GOETHALSL., HAUSTERMANS K., NAFTEUX P., PENNINCKX F., GEBOES K.,LERUT T., ECTORS N.: Expression of carbonic anhydrase IX (CA IX), ahypoxia-related protein, rather than vascular-endothelial growth factor(VEGF), a pro-angiogenic factor, correlates with an extemely poorprognosis in esophageal and gastric adenocarcinomas. Ann. Surg.,2006; 243(3): 334-340.96
Objective: To evaluate the expression of carbonic anhydrase IX (CAIX) and vascular-endothelial growth factor (VEGF) in esophageal andgastric adenocarcinomas and in turn with the histologic subtype.Summary background data: Tumor hypoxia is an important factor intherapy resistance. A low oxygen concentration in tumors stimulatesa.o. the expression of CA IX, a marker of hypoxia, and VEGF, a proangiogenicfactor.Methods: We evaluated the immunohistochemical expression of CA IXand VEGF on paraffin-embedded material of 154 resectionspecimens: 39 esophageal, 73 cardiac, and 42 distal gastricadenocarcinomas (UICC classification). The adenocarcinomas weresubtyped according to the Lauren classification (intestinal- and diffusetype).Statistical analysis: chi test, Kaplan-Meier survival analysis, log-ranktest, and Cox proportional hazards model.Results: CA IX and VEGF expression were independent of thelocalization of the tumor. However, intestinal-type adenocarcinomasshowed a significantly higher expression of CA IX as well as VEGFthan diffuse-type tumors. VEGF expression was associated with ahigh microvessel density. Although survival analysis showed that CAIX expression (P = 0.008) as well as the coexpression of CA IX andVEGF (P = 0.008) correlate with a poor outcome, only CA IXexpression is an independent prognostic factor for overall survival andmetastasis-free survival.Conclusion: The difference in expression of CA IX and VEGF betweenintestinal- and diffuse-type adenocarcinomas may possibly explain thedifferent clinical behavior of these tumors. CA IX expression, ratherthan VEGF positivity in tumors, enables the identification of asubpopulation, characterized by a more aggressive behavior and apoorer prognosis.DUPONT L.J., BLONDEAU K., SIFROM D., VAN RAEMDONCK D.M.,VERLEDEN G.M.: Is gastro-oesophageal reflux more frequent in lungtransplant patients with chronic rejection? J. Heart Lung Transplant.,2006; 25: S84(117).Chronic allograft dysfunction predisposes to poor long-term survivalafter lung transplantation (LTx). It has been suggested that gastrooesophagealreflux (GOR) contributes to non-alloimmune lung injuryand the development of BOS. A cross-sectional study was performedto determine the prevalence of GOR in a cohort of lung transplantrecipients by means of combined oesophageal 24-hr pH andimpedance testing. This allowed accurate detection of all GOR events(acid and nonacid) while acid suppression therapy (omeprazole 20 mgor ranitidine 300 mg)- was continued. Thirty-six patients were included97
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CYRURGIE2006
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Heelmeesters allerhande, verenig u!
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INHOUDSOPGAVEAbdominale Heelkunde 1
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De resultaten van een grote Noord-A
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VEGF (P = 0.008) correlate with a p
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severe ulcerative ileitis and jejun
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tekens op CT en/of MRI kunnen een b
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data we propose a scoring system in
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ABDOMINALETRANSPLANTATIECHIRURGIECA
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DYCKMANS K., LERUT E., GILLARD P.,
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LERUT J., ORLANDO G., ADAM R., SABB
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histopathologic diagnostic process.
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additional stimulants that the inna
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ARTIKELS UIT HETLEUVENSE NETCREVITS
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PRUYT M., DEVRIENDT D., VANNESTE A.
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BOSHOFF D., BUDTS W., MERTENS L., E
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FLAMENG W., MEURIS B., HERIJGERS P.
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prosthetic valve endocarditis who w
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in these patients We present a case
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SERCA2a. In SKO mice, gene-targeted
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MULTIDISCIPLINAIRBORSTCENTRUMMORALE
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east implant. Only two other cases
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Object: Based on data from primate
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SISCOM hyperperfusion cluster and M
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ONCOLOGISCHEHEELKUNDEBROUNS F., SCH
Page 54 and 55: infiltrative multilobular spindle c
Page 56 and 57: multivariable Cox model adjusted fo
Page 58 and 59: We retrospectively evaluated a surg
Page 60 and 61: We performed resection arthroplasty
Page 62 and 63: earing posterior-stabilised. To do
Page 64 and 65: age and key pinch strength. The dif
Page 66 and 67: FABRY K., LAMMENS J., DELHEY P., ST
Page 68 and 69: cases. The mean Knee Society’s kn
Page 70 and 71: short-term solution for his fractur
Page 72 and 73: the foot and result in major septic
Page 75 and 76: SAEGEMAN V., LISMONT D., VERDUYCKT
Page 77 and 78: Objective: The objective of this st
Page 79 and 80: VICTOR J., BELLEMANS J.: Physiologi
Page 81 and 82: skin construct displays authentic f
Page 83 and 84: Bewertung des Spenderdefektes ergab
Page 85 and 86: HIERNER R., BERGER A.: Options and
Page 87 and 88: vascularized ulnar nerve graft and
Page 89 and 90: cranial bone and dura which cannot
Page 91 and 92: defects.Adequate debridement, early
Page 93 and 94: Patients and Methods: Between 1995
Page 95 and 96: MASSAGE P., VANDENHOF B., VRANCKX J
Page 97 and 98: Background: High pressure injuries
Page 99 and 100: VERMEULEN P., DICKENS S., VRANCKX J
Page 101 and 102: inhibitors that neutralize the impa
Page 103: internship. These components repres
Page 107 and 108: patients were diagnosed with acute
Page 109 and 110: Conclusions: This study demonstrate
Page 111 and 112: progressive accumulation of FVIII a
Page 113 and 114: his name to this condition through
Page 115 and 116: gevallen, beschouwen wij de minimaa
Page 117 and 118: Table 1Reperfusion time(min)PVR(dyn
Page 119 and 120: transplantation; dehiscence (n = 25
Page 121 and 122: upon reperfusion results from a red
Page 123 and 124: VAN DE WAUWER C., VAN RAEMDONCK D.E
Page 125 and 126: Bronchiolitis obliterans syndrome (
Page 127 and 128: noodzakelijk een beter inzicht te v
Page 129 and 130: patients of 70 years and older trea
Page 131 and 132: of debate. A good pain relief can b
Page 133 and 134: VAN GESTEL L., NIJS S., BROOS P.: T
Page 135 and 136: UROLOGIEALBERSEN M., JONIAU S., VAN
Page 137 and 138: children achieve bladder and bowel
Page 139 and 140: Results: Ninety-five percent of the
Page 141 and 142: esistant to degradation, but at 365
Page 143 and 144: Results: Although the surgery was m
Page 145 and 146: DE RIDDER D.: Conservatieve aanpak
Page 147 and 148: pressures were measured. The effect
Page 149 and 150: GOEMAN L., JONIAU S., OYEN R., VAN
Page 151 and 152: pelvic lymph node status were not w
Page 153 and 154: literature on nephron-sparing surge
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on overall survival was studied. Su
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materials, although it was architec
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Material und Methoden: Von 13 Zentr
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a remarkable higher number of forei
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VAN CALSTEREN K., VAN MENSEL K., JO
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VANDE WALLE J.G.J., BOGAERT G.A., M
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Introduction & Objectives: Control
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VAATHEELKUNDEBLADT O., MALEUX G., H
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FOURNEAU I., SABBE T., DAENENS K.,
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computed tomography (CT) and magnet
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We report an unusual case of a uret
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during GPIb stimulation, its activa
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2006 - UZ Leuven

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