2006 - UZ Leuven

termination of induction chemotherapy were refused for surgery. 13patients underwent an EPP, 2 patients were irresecable due to chestwall invasion. Post op mortality of EPP was 7.7% (n=1). Post surgicalcomplications were re-thoracotomy for bleeding (n=1), atrial fibrillation(n=7), ARDS (n=2), DVT (n=1). 3 patients couldn’t finish theradiotherapy course due to tumour recurrence and 1 patient diedshortly after the radiotherapy due to BOOP. Survival of resectedpatients (n=13) was 17 months and of patients who completed the fullmultidisciplinary treatment (n=0) was 22 months after diagnosis.Conclusion: This study shows the feasibility of this multidisciplinaryapproach showing a benefit for patients able to complete the alltreatment. Careful selection is mandatory to define potential targetgroups.NEYRINCK A.P., REGA F.R., VAN DE WAUWER C., GEUDENS N.,VERLEDEN G.M., WOUTERS P., LERUT T.E., VAN RAEMDONCK D.:Lungs from HBD have an increased inflammatory status and impairedperformance compared to NHBD. J. Heart Lung Transplant, 2006; 25:S67(70).Aim: Non-heart-beating donors (NHBD) have been advocated toovercome organ shortage in lung transplantation. Brain death (BD) inthe heart-beating donor (HBD) may be an underestimated risk factorfor donor lung injury. We postulated that 1 h of warm ischemia inNHBD is less detrimental to the donor lung than BD in HBD.Methods: Pigs were divided in 3 groups (n=10/group). In group I(HBD), BD was induced by intracranial balloon inflation. In group II(CONT) the balloon was not inflated. In group III (NHBD) cardiacarrest was induced by myocardial fibrillation. After 5 h of mechanicalventilation, lungs in HBD and CONT were flushed. Unflushed grafts inNHBD were explanted after 1 h of warm ischemia and 4 h of topicalcooling. Graft performance (pulmonary vascular resistance (PVR) andplateau airway pressure (PlatAwP)) of the left lung was evaluatedduring 1 h in an isolated ventilation and reperfusion model. Rightlungs were not perfused. Pro-inflammatory cytokines (IL-8 and IL-1β)were measured in broncho-alveolar lavage fluid from both lungs.Results: A cushing response occured in HBD. Results are listed inTable I and 2 (mean ± SEM). (table 2)†, p < 0.05 HBD compared toNHBD; *: p < 0.05 HBD compared to CONT.108