2006 - UZ Leuven

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SERCA2a. In SKO mice, gene-targeted replacement of SERCA2a bySERCA2b, a pump with a higher Ca(2+) affinity, results in cardiachypertrophy and dysfunction. The stronger PLB inhibition on cardiacmorphology and performance observed in SKO was investigated herein DKO mice, which were obtained by crossing SKO with PLB(-/-)mice. The affinity for Ca(2+) of SERCA2 was found to be furtherincreased in these DKO mice. Relative to wild-type and SKO mice,DKO mice were much less spontaneously active and showed areduced life span. The DKO mice also displayed a severe cardiacphenotype characterized by a more pronounced concentrichypertrophy, diastolic dysfunction and increased ventricular stiffness.Strikingly, beta-adrenergic or forced exercise stress induced acuteheart failure and death in DKO mice. Therefore, the increased PLBinhibition represents a compensation for the imposed high Ca(2+)-affinity of SERCA2b in the SKO heart. Limiting SERCA2's affinity forCa(2+) is physiologically important for normal cardiac function. Animproved Ca(2+) transport in the sarcoplasmic reticulum may correctCa(2+) mishandling in heart failure, but a SERCA pump with a muchhigher Ca(2+) affinity may be detrimental.VLASSELAERS D., DESMET M., DESMET L., MEYNS B., DENS J.:Ventricular unloading with a miniature axial flow pump in combinationwith extracorporeal membrane oxygenation. Intensive Care Med., <strong>2006</strong>;32(2): 329-333.Objective: ECMO for acute cardiorespiratory failure is an establishedtherapeutic option. Persistent insufficient unloading of the left ventricle(LV) can compromise recovery of ventricular function. We decided toinsert a miniature rotary blood pump (Impella) for decompression ofthe LV. In contrast to previous experience with this new device, whereit was generally used for postcardiotomy heart failure or cardiogenicshock and inserted in the operating room or the catheter laboratory,this is the first report describing the potential of this technology in theintensive care unit, in a patient on ECMO and the value ofechocardiography guidance.Patient: A 13-year-old boy with a history of congenital heart diseasewas admitted to the ICU with acute cardio-respiratory failure.Interventions: On day 2 venoarterial ECMO was instituted because ofworsening cardiorespiratory insufficiency refractory to conventionaltreatment. On day 5 a percutaneous rotary blood pump was insertedto decompress the LV.Conclusions: A percutaneous miniature rotary blood pump can be analternative to decompress a failing LV in the setting of VA-ECMO.Echocardiography can avoid the use of fluoroscopy and the transportto a catheter laboratory to insert the rotary pump.34
WUYTS W.A., HERIJGERS P., BUDTS W., DE WEVER W., DELCROIX W.:Extensive dissection of the pulmonary artery treated with combinedheart-lung transplantation. J. Thorac. Cardiovasc. Surg., <strong>2006</strong>; 132(1):205-206.A case of extensive dissection of the pulmonary artery was seen in awoman with pulmonary arterial hypertension (PAH) with severeinterscapular pain. The diagnosis was made on computedtomographic (CT) scan of the chest. This case report shows that in apatient with PAH with thoracic pain, dissection of the pulmonary arteryneeds to be excluded. The pathogenesis of pulmonary arterydissection is discussed, as well as diagnosis and therapeuticinterventions.35
Page 1: CYRURGIE2006
Page 4 and 5: Heelmeesters allerhande, verenig u!
Page 7: INHOUDSOPGAVEAbdominale Heelkunde 1
Page 10 and 11: De resultaten van een grote Noord-A
Page 12 and 13: VEGF (P = 0.008) correlate with a p
Page 14 and 15: severe ulcerative ileitis and jejun
Page 16 and 17: tekens op CT en/of MRI kunnen een b
Page 18 and 19: data we propose a scoring system in
Page 20 and 21: ABDOMINALETRANSPLANTATIECHIRURGIECA
Page 22 and 23: DYCKMANS K., LERUT E., GILLARD P.,
Page 24 and 25: LERUT J., ORLANDO G., ADAM R., SABB
Page 26 and 27: histopathologic diagnostic process.
Page 28 and 29: additional stimulants that the inna
Page 30 and 31: ARTIKELS UIT HETLEUVENSE NETCREVITS
Page 32 and 33: PRUYT M., DEVRIENDT D., VANNESTE A.
Page 34 and 35: BOSHOFF D., BUDTS W., MERTENS L., E
Page 36 and 37: FLAMENG W., MEURIS B., HERIJGERS P.
Page 38 and 39: prosthetic valve endocarditis who w
Page 40 and 41: in these patients We present a case
Page 44 and 45: MULTIDISCIPLINAIRBORSTCENTRUMMORALE
Page 46 and 47: east implant. Only two other cases
Page 48 and 49: Object: Based on data from primate
Page 50 and 51: SISCOM hyperperfusion cluster and M
Page 52 and 53: ONCOLOGISCHEHEELKUNDEBROUNS F., SCH
Page 54 and 55: infiltrative multilobular spindle c
Page 56 and 57: multivariable Cox model adjusted fo
Page 58 and 59: We retrospectively evaluated a surg
Page 60 and 61: We performed resection arthroplasty
Page 62 and 63: earing posterior-stabilised. To do
Page 64 and 65: age and key pinch strength. The dif
Page 66 and 67: FABRY K., LAMMENS J., DELHEY P., ST
Page 68 and 69: cases. The mean Knee Society’s kn
Page 70 and 71: short-term solution for his fractur
Page 72 and 73: the foot and result in major septic
Page 75 and 76: SAEGEMAN V., LISMONT D., VERDUYCKT
Page 77 and 78: Objective: The objective of this st
Page 79 and 80: VICTOR J., BELLEMANS J.: Physiologi
Page 81 and 82: skin construct displays authentic f
Page 83 and 84: Bewertung des Spenderdefektes ergab
Page 85 and 86: HIERNER R., BERGER A.: Options and
Page 87 and 88: vascularized ulnar nerve graft and
Page 89 and 90: cranial bone and dura which cannot
Page 91 and 92: defects.Adequate debridement, early
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Patients and Methods: Between 1995
Page 95 and 96:
MASSAGE P., VANDENHOF B., VRANCKX J
Page 97 and 98:
Background: High pressure injuries
Page 99 and 100:
VERMEULEN P., DICKENS S., VRANCKX J
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inhibitors that neutralize the impa
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internship. These components repres
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Objective: To evaluate the expressi
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patients were diagnosed with acute
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Conclusions: This study demonstrate
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progressive accumulation of FVIII a
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his name to this condition through
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gevallen, beschouwen wij de minimaa
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Table 1Reperfusion time(min)PVR(dyn
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transplantation; dehiscence (n = 25
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upon reperfusion results from a red
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VAN DE WAUWER C., VAN RAEMDONCK D.E
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Bronchiolitis obliterans syndrome (
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noodzakelijk een beter inzicht te v
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patients of 70 years and older trea
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of debate. A good pain relief can b
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VAN GESTEL L., NIJS S., BROOS P.: T
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UROLOGIEALBERSEN M., JONIAU S., VAN
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children achieve bladder and bowel
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Results: Ninety-five percent of the
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esistant to degradation, but at 365
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Results: Although the surgery was m
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DE RIDDER D.: Conservatieve aanpak
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pressures were measured. The effect
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GOEMAN L., JONIAU S., OYEN R., VAN
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pelvic lymph node status were not w
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literature on nephron-sparing surge
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on overall survival was studied. Su
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materials, although it was architec
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Material und Methoden: Von 13 Zentr
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a remarkable higher number of forei
Page 163 and 164:
VAN CALSTEREN K., VAN MENSEL K., JO
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VANDE WALLE J.G.J., BOGAERT G.A., M
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Introduction & Objectives: Control
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VAATHEELKUNDEBLADT O., MALEUX G., H
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FOURNEAU I., SABBE T., DAENENS K.,
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computed tomography (CT) and magnet
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We report an unusual case of a uret
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during GPIb stimulation, its activa
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2006 - UZ Leuven

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