2006 - UZ Leuven

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FLAMENG W., MEURIS B., HERIJGERS P., HERREGODS M.C.:Prosthesis-patient mismatch is not clinically relevant in aortic valvereplacement using the Carpentier-Edwards Perimount valve. Ann.Thorac. Surg., 2006; 82(2): 530-536.Background: Previous studies have shown that prosthesis-patientmismatch (PPM) results in higher early and late mortality afterbioprosthetic aortic valve replacement. Careful selection of stentedbioprostheses was recommended to avoid inadequate effective orificearea. We studied the incidence of PPM and its potential effects onclinical outcome in patients undergoing aortic valve replacement usingthe Carpentier-Edwards Perimount bioprosthesis.Methods: Independent predictors of early and late mortality andhospital readmission for cardiac reasons were defined in 506 patients(mean age, 73 years; range, 57 to 87 years) by multivariate analysis.Mean follow-up was 6.1 +/- 4.8 years; maximum follow-up was 18.6years.Results: The incidence of severe PPM (effective orifice area index 0.65 and < 0.85) was 20%. Multivariate analysis revealed thatmoderate PPM was not an independent predictor of early mortality,late mortality, or hospital readmission for cardiac reasons. Reductionof septal hypertrophy was similar in patients with and withoutmoderate PPM.Conclusions: The incidence of severe PPM is virtually nonexistentafter aortic valve replacement using the Carpentier-EdwardsPerimount valve. Moderate PPM is found in 20% of cases and isclinically irrelevant in this population.FLAMENG W., MEURIS B., YPERMAN J., DE VISSCHER G., HERIJGERSP., VERBEKEN E.: Factors influencing calcification of cardiacbioprotheses in adolescent sheep. J. Thorac. Cardiovasc. Surg., 2006;132(1): 89-98.Objective: We determined the possible effects of age,antimineralization treatments, circulatory implant conditions,prosthesis design, and valve-related structural aspects on valvecalcification in adolescent sheep.Methods: Calcium content was measured by means of atomicabsorption spectrometry in bioprostheses implanted in 120 sheep(age
pericardial, wall portion or cusp), and antimineralization treatment areindependent factors influencing calcification; implant duration beyond3 months was not. In juvenile sheep (age 5 months) the wall portion,as well as the cusps of the prosthesis, calcified significantly more thanin adolescent sheep (age 11 months). Irrespective of age, the cuspsof valves implanted in the mitral position calcified more than those inthe pulmonary position. The wall portion of stentless valves calcifiedmore than that of stented valves, and pericardial valves calcified lessthan porcine valves. The surfactant (Tween 80, No-React, and alphaamino-oleicacid) and alcohol (ethanol and octanediol) treatmentsignificantly reduced cusp calcification; sodium dodecylsulfate did not.None of the anticalcification treatments was able to prevent wallcalcification in stentless porcine valves.Conclusion: These findings suggest that tissue valve calcification isdetermined by many independent factors, which can be identified byusing adolescent sheep as a preclinical in vivo model.HILL E.E., HERIJGERS P., HERREGODS M.C., PEETERMANS W.E.:Infective endocarditis treated with linezolid: case report and literaturereview. Eur. J. Clin. Microbiol. Infect. Dis., 2006; 25(3): 202-204.Infective endocarditis (IE) remains a serious disease with mortalityrates of 20–25% after 1 year [1]. Antibiotic resistance may limit thetherapeutic options and compromise the outcome of infectiveendocarditis. Linezolid belongs to the oxazolidinone class ofantimicrobial agents. It has activity against multidrug-resistant grampositiveorganisms, including coagulase-negative staphylococci(CNS), methicillin-resistant Staphylococcus aureus (MRSA),glycopeptide intermediate S. aureus and vancomycin- resistantEnterococcus [2]. Linezolid has 100% bioavailability, allowingcontinuation of treatment via the oral route, an elimination half-life of5–7 h, and good tissue penetration. Linezolid has no cross-resistancewith other classes of antibiotics. Due to non-enzymatic oxidation of themorpholine ring, its clearance is not dependent on renal function orhepatic enzyme action. The most common adverse effects aregastrointestinal disturbances, and rarer complications are associatedwith prolonged linezolid therapy, such as reversible myelosuppressionwith anemia and thrombocytopenia, and peripheral and opticalneuropathy. The oxazolidinones are reversible non-selectivemonoamine oxidase inhibitors. Therefore, caution is required whenprescribing them with adrenergic or serotonergic agents such aspseudoephedrine, phenylpropanolamine, and selective serotonergicreuptake inhibitors [2, 3]. Successes and failures have been reportedfor IE cases treated with linezolid. We report the case of a patient with29
Page 1: CYRURGIE2006
Page 4 and 5: Heelmeesters allerhande, verenig u!
Page 7: INHOUDSOPGAVEAbdominale Heelkunde 1
Page 10 and 11: De resultaten van een grote Noord-A
Page 12 and 13: VEGF (P = 0.008) correlate with a p
Page 14 and 15: severe ulcerative ileitis and jejun
Page 16 and 17: tekens op CT en/of MRI kunnen een b
Page 18 and 19: data we propose a scoring system in
Page 20 and 21: ABDOMINALETRANSPLANTATIECHIRURGIECA
Page 22 and 23: DYCKMANS K., LERUT E., GILLARD P.,
Page 24 and 25: LERUT J., ORLANDO G., ADAM R., SABB
Page 26 and 27: histopathologic diagnostic process.
Page 28 and 29: additional stimulants that the inna
Page 30 and 31: ARTIKELS UIT HETLEUVENSE NETCREVITS
Page 32 and 33: PRUYT M., DEVRIENDT D., VANNESTE A.
Page 34 and 35: BOSHOFF D., BUDTS W., MERTENS L., E
Page 38 and 39: prosthetic valve endocarditis who w
Page 40 and 41: in these patients We present a case
Page 42 and 43: SERCA2a. In SKO mice, gene-targeted
Page 44 and 45: MULTIDISCIPLINAIRBORSTCENTRUMMORALE
Page 46 and 47: east implant. Only two other cases
Page 48 and 49: Object: Based on data from primate
Page 50 and 51: SISCOM hyperperfusion cluster and M
Page 52 and 53: ONCOLOGISCHEHEELKUNDEBROUNS F., SCH
Page 54 and 55: infiltrative multilobular spindle c
Page 56 and 57: multivariable Cox model adjusted fo
Page 58 and 59: We retrospectively evaluated a surg
Page 60 and 61: We performed resection arthroplasty
Page 62 and 63: earing posterior-stabilised. To do
Page 64 and 65: age and key pinch strength. The dif
Page 66 and 67: FABRY K., LAMMENS J., DELHEY P., ST
Page 68 and 69: cases. The mean Knee Society’s kn
Page 70 and 71: short-term solution for his fractur
Page 72 and 73: the foot and result in major septic
Page 75 and 76: SAEGEMAN V., LISMONT D., VERDUYCKT
Page 77 and 78: Objective: The objective of this st
Page 79 and 80: VICTOR J., BELLEMANS J.: Physiologi
Page 81 and 82: skin construct displays authentic f
Page 83 and 84: Bewertung des Spenderdefektes ergab
Page 85 and 86: HIERNER R., BERGER A.: Options and
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vascularized ulnar nerve graft and
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cranial bone and dura which cannot
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defects.Adequate debridement, early
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Patients and Methods: Between 1995
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MASSAGE P., VANDENHOF B., VRANCKX J
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Background: High pressure injuries
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VERMEULEN P., DICKENS S., VRANCKX J
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inhibitors that neutralize the impa
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internship. These components repres
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Objective: To evaluate the expressi
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patients were diagnosed with acute
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Conclusions: This study demonstrate
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progressive accumulation of FVIII a
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his name to this condition through
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gevallen, beschouwen wij de minimaa
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Table 1Reperfusion time(min)PVR(dyn
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transplantation; dehiscence (n = 25
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upon reperfusion results from a red
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VAN DE WAUWER C., VAN RAEMDONCK D.E
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Bronchiolitis obliterans syndrome (
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noodzakelijk een beter inzicht te v
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patients of 70 years and older trea
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of debate. A good pain relief can b
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VAN GESTEL L., NIJS S., BROOS P.: T
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UROLOGIEALBERSEN M., JONIAU S., VAN
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children achieve bladder and bowel
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Results: Ninety-five percent of the
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esistant to degradation, but at 365
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Results: Although the surgery was m
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DE RIDDER D.: Conservatieve aanpak
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pressures were measured. The effect
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GOEMAN L., JONIAU S., OYEN R., VAN
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pelvic lymph node status were not w
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literature on nephron-sparing surge
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on overall survival was studied. Su
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materials, although it was architec
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Material und Methoden: Von 13 Zentr
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a remarkable higher number of forei
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VAN CALSTEREN K., VAN MENSEL K., JO
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VANDE WALLE J.G.J., BOGAERT G.A., M
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Introduction & Objectives: Control
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VAATHEELKUNDEBLADT O., MALEUX G., H
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FOURNEAU I., SABBE T., DAENENS K.,
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computed tomography (CT) and magnet
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We report an unusual case of a uret
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during GPIb stimulation, its activa
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2006 - UZ Leuven

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