2006 - UZ Leuven

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ONCOLOGISCHEHEELKUNDEBROUNS F., SCHUERMANS A., VERHAEGEN J., DE WEVER I., STAS M.:Infection assessment of totally implanted long-term venous accessdevices. J. Vasc. Access, 2006; 7: 24-28.Aim: Comparison of catheter tip versus port content culture techniquesto assess infection in totally implanted vascular access devices(TIVAD).Materials and methods: Comparison of pocket swab, catheter-tip andport content cultures after removing the silicon puncture septum in aprospectively collected consecutive series of 102 TIVAD removed forclinical suspicion of infection, between May 2000 and March 2003.Results: 102 totally implanted port-catheters in 98 patients, ageranging from 1 to 90 years (median 53 years), were removed 7 to2616 days after insertion (median 210 days). Infection of the pocketsurrounding the port was found in 21 cases, all proven by a positiveculture of the pocket swab. Out of the remaining 81 cases withoutpocket infection, 32 had only a positive catheter tip culture, whereas56 had a positive port content culture (p=0.0002). Always the samemicroorganism was isolated in the 32 patients with positive catheter tipand port content cultures. The main organisms identified with TIVADwere Coagulase Negative Staphylococcus (CNS) (41 cases) andCandida sp (15 cases). Eight out of the 21 pocket infections werecaused by Staphylococcus aureus.Conclusion: In the presence of local signs of infection, taking culturesof the pocket surrounding the port is sufficient for diagnostic purposes.When infection is localized within the device only, port content culturestaken after removal of the silicon septum are more often positive thancultures of the catheter tip, and constitute therefore a more reliabletool for the assessment of TIVAD infection.DE RAEDT T., COOLS J., DEBIEC-RYCHTER M., BREMS H., MENTENSN., SCIOT R., HIMPENS J., DE WEVER I., SCHOFFSKI P., MARYNEN P.,LEGIUS P.: Intestinal neurofibromatosis is a subtype of familial GISTand results from a dominant activating mutation in PDGFRA.Gastroenterology, 2006; 131(6): 1907-1912.44
Background & aims: Intestinal neurofibromatosis (Online Mendelianinheritance in Man database number 162220) is an alternate form ofneurofibromatosis. Patients present with neurofibromas limited to theintestine in the absence of any other typical features of NF1 and NF2.At present, the molecular basis of intestinal neurofibromatosis remainselusive. The aim of the present study was to find the gene responsiblefor intestinal neurofibromatosis and to characterize functionally themutation.Methods: Three candidate genes (NF1, KIT, and PDGFRA) werescreened for mutations in 3 sisters diagnosed with intestinalneurofibromatosis. Five tumors were available for pathologicexamination. Activation (phosphorylation) of PDGFRalpha wassubsequently tested by Western blot analysis on a transfected 293Tand Ba/F3 cell line.Results: We found an inherited mutation (Y555C) in thejuxtamembrane domain of PDGFRA in the affected individuals. TheY555C mutation leads to autophosphorylation and thus activation ofPDGFRalpha. These observations confirm that PDGFRalpha(Y555C)is an oncogenic kinase. The clinical phenotype in the reported familyresembles the syndrome of familial gastrointestinal stromal tumors(familial GIST). Somatic activating mutations in KIT and PDGFRA arefrequent in sporadic GISTs, and mutations in both genes have alsobeen described in familial GISTs. The tumors in the reported familyare morphologically identical to intestinal neurofibromas, but,immunohistochemically, they do not express S100 or any of theknown GIST markers.Conclusions: The inherited PDGFRA mutation in the reported familyshows that intestinal neurofibromatosis is allelic to familial GISTcaused by PDGRA mutations. We therefore propose that thesetumors be classified as familial KIT-negative gastrointestinal stromaltumors.DERAEDT K., VANDER POORTEN V., VAN GEET C., RENARD M., DEWEVER I., SCIOT R.: Multifocal kaposiform haemangioendothelioma.Virchows Arch 2006; 448: 843-846.Kaposiform haemangioendothelioma (KHE) is a rare, locallyaggressive vascular spindle cell proliferation, with resemblance toKaposi's sarcoma. This tumour usually occurs in skin andretroperitoneum of infants and young children and is oftencomplicated by the Kasabach-Merritt phenomenon (KMP). A 3-yearoldboy presented with a right submandibular swelling due tolymphadenopathies, a violaceous skin lesion at the left commissure ofthe lips and an ill-defined lesion in the right thyroid lobe. There weresome signs of KMP. Histological examination revealed a typical45
Page 1: CYRURGIE2006
Page 4 and 5: Heelmeesters allerhande, verenig u!
Page 7: INHOUDSOPGAVEAbdominale Heelkunde 1
Page 10 and 11: De resultaten van een grote Noord-A
Page 12 and 13: VEGF (P = 0.008) correlate with a p
Page 14 and 15: severe ulcerative ileitis and jejun
Page 16 and 17: tekens op CT en/of MRI kunnen een b
Page 18 and 19: data we propose a scoring system in
Page 20 and 21: ABDOMINALETRANSPLANTATIECHIRURGIECA
Page 22 and 23: DYCKMANS K., LERUT E., GILLARD P.,
Page 24 and 25: LERUT J., ORLANDO G., ADAM R., SABB
Page 26 and 27: histopathologic diagnostic process.
Page 28 and 29: additional stimulants that the inna
Page 30 and 31: ARTIKELS UIT HETLEUVENSE NETCREVITS
Page 32 and 33: PRUYT M., DEVRIENDT D., VANNESTE A.
Page 34 and 35: BOSHOFF D., BUDTS W., MERTENS L., E
Page 36 and 37: FLAMENG W., MEURIS B., HERIJGERS P.
Page 38 and 39: prosthetic valve endocarditis who w
Page 40 and 41: in these patients We present a case
Page 42 and 43: SERCA2a. In SKO mice, gene-targeted
Page 44 and 45: MULTIDISCIPLINAIRBORSTCENTRUMMORALE
Page 46 and 47: east implant. Only two other cases
Page 48 and 49: Object: Based on data from primate
Page 50 and 51: SISCOM hyperperfusion cluster and M
Page 54 and 55: infiltrative multilobular spindle c
Page 56 and 57: multivariable Cox model adjusted fo
Page 58 and 59: We retrospectively evaluated a surg
Page 60 and 61: We performed resection arthroplasty
Page 62 and 63: earing posterior-stabilised. To do
Page 64 and 65: age and key pinch strength. The dif
Page 66 and 67: FABRY K., LAMMENS J., DELHEY P., ST
Page 68 and 69: cases. The mean Knee Society’s kn
Page 70 and 71: short-term solution for his fractur
Page 72 and 73: the foot and result in major septic
Page 75 and 76: SAEGEMAN V., LISMONT D., VERDUYCKT
Page 77 and 78: Objective: The objective of this st
Page 79 and 80: VICTOR J., BELLEMANS J.: Physiologi
Page 81 and 82: skin construct displays authentic f
Page 83 and 84: Bewertung des Spenderdefektes ergab
Page 85 and 86: HIERNER R., BERGER A.: Options and
Page 87 and 88: vascularized ulnar nerve graft and
Page 89 and 90: cranial bone and dura which cannot
Page 91 and 92: defects.Adequate debridement, early
Page 93 and 94: Patients and Methods: Between 1995
Page 95 and 96: MASSAGE P., VANDENHOF B., VRANCKX J
Page 97 and 98: Background: High pressure injuries
Page 99 and 100: VERMEULEN P., DICKENS S., VRANCKX J
Page 101 and 102: inhibitors that neutralize the impa
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internship. These components repres
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Objective: To evaluate the expressi
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patients were diagnosed with acute
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Conclusions: This study demonstrate
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progressive accumulation of FVIII a
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his name to this condition through
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gevallen, beschouwen wij de minimaa
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Table 1Reperfusion time(min)PVR(dyn
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transplantation; dehiscence (n = 25
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upon reperfusion results from a red
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VAN DE WAUWER C., VAN RAEMDONCK D.E
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Bronchiolitis obliterans syndrome (
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noodzakelijk een beter inzicht te v
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patients of 70 years and older trea
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of debate. A good pain relief can b
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VAN GESTEL L., NIJS S., BROOS P.: T
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UROLOGIEALBERSEN M., JONIAU S., VAN
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children achieve bladder and bowel
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Results: Ninety-five percent of the
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esistant to degradation, but at 365
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Results: Although the surgery was m
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DE RIDDER D.: Conservatieve aanpak
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pressures were measured. The effect
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GOEMAN L., JONIAU S., OYEN R., VAN
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pelvic lymph node status were not w
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literature on nephron-sparing surge
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on overall survival was studied. Su
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materials, although it was architec
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Material und Methoden: Von 13 Zentr
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a remarkable higher number of forei
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VAN CALSTEREN K., VAN MENSEL K., JO
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VANDE WALLE J.G.J., BOGAERT G.A., M
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Introduction & Objectives: Control
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VAATHEELKUNDEBLADT O., MALEUX G., H
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FOURNEAU I., SABBE T., DAENENS K.,
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computed tomography (CT) and magnet
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We report an unusual case of a uret
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during GPIb stimulation, its activa
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2006 - UZ Leuven

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