2006 - UZ Leuven

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Object: Based on data from primate experiments it is known thatrotational acceleration in the sagittal plane and in a forward directionis most likely to produce acute subdural hematomas due to bridgingvein rupture. For protection against these lesions, knowledge ofrotational acceleration tolerance levels in humans is required. In thepresent study the authors analyze human tolerance levels for bridgingvein rupture by performing head impact tests in cadavers.Methods: Ten unembalmed cadavers were subjected to 18 occipitalimpacts producing head rotation in the sagittal plane with varyingrotational acceleration magnitudes and pulse durations. Rotationalacceleration was calculated from the linear acceleration historiesrecorded by three uniaxial accelerometers mounted on the side of thehead. Bridging vein ruptures were detected by injecting contrast dyeinto the superior sagittal sinus under fluoroscopy and by autopsyprocedures. Bridging vein ruptures were produced in six head impacttests: one test with a pulse duration of 5.2 msec and a peak rotationalacceleration of 13,411 rad/second2; three tests with a pulse durationbetween 7 and 8 msec and a peak rotational acceleration of 12,558,10,607, and 8567 rad/second2; and two tests with a pulse durationlonger than 10 msec and a peak rotational acceleration as low as5267 rad/second2.Conclusions: This is the only cadaveric study of bridging vein rupturefocused on short pulse durations, which are usually associated withfalls. The data suggest a tolerance level of approximately 10,000rad/second2 for pulse durations shorter than 10 msec, which seems todecrease for longer pulse durations.DE VLEESCHOUWER S., RAPP M., SORG R.V., STEIGER H.J.,STUMMER W., VAN GOOL S., SABEL M.: Dendritic cell vaccination inpatients with malignant gliomas: actual status and future directions.Neurosurgery, <strong>2006</strong>; 59(5): 988-1000.Objective: Despite recent advances in neurosurgical resectiontechniques, radiation therapy, and chemotherapy, malignant gliomascontinue to have a dismal prognosis because relapses areunavoidable.Methods: Dendritic cell vaccination has recently emerged as apromising type of active immunotherapy that aims to induce ratherthan transfer specific antitumor immune responses in patients. Activeimmunotherapy is the only type of immunotherapy able to induceimmunological memory.Results: Although an increasing number of small clinical trials showsafety, feasibility, and immunological and clinical responses, thistechnology requires further clarification of some critical basic andclinical issues before its presumed place in the treatment of malignant40
gliomas can be specified. This article addresses the basic and clinicalpitfalls that, more than with conventional therapies, may interfere withthe potential benefits of this approach.Conclusion: Considering the particular mechanisms involved in theimmune modulation of tumor biology using dendritic cell-basedvaccinations, the authors summarize the arguments in favor of afurther, appropriate assessment of this technology.DUPONT P., VAN PAESSCHEN W., PALMINI A., AMBAYI R., VAN LOONJ., GOFFIN J., WECKHUYSEN S., SUNAERT S., THOMAS B., DEMAERELP., SCIOT R., BECKER A., VANBILLOEN H., MORTELMANS L., VANLAERE K.: Ictal perfusion patterns associated with single MRI-visiblefocal dysplastic lesions: implications for the non-invasive delineationof the epileptogenic zone. Epilepsia, <strong>2006</strong>; 47(9): 1550-1557.Background: Invasive electroencephalogram (EEG) studies are oftenconsidered necessary to localize the epileptogenic zone in partialepilepsies associated with focal dysplastic lesions (FDL). Our aim wasto evaluate the relationships between subtraction ictal SPECTcoregistered with magnetic resonance imaging (MRI) (SISCOM)hyperperfusion clusters and MRI-visible FDL, and to establish apreliminary algorithm for a noninvasive presurgical evaluation protocolfor MRI-visible FDLs in patients with refractory epilepsy.Methods: Fifteen consecutive patients with refractory partial epilepsyand a single MRI-visible FDL underwent a noninvasive presurgicalevaluation including SISCOM. Each hyperperfusion cluster wasvisually analyzed, automatically quantitated, and its distance form thelesion as outlined on the MRI was measured. In patients whounderwent surgery, the volumes of resected brain tissue containingthe FDL, the SISCOM hyperperfusion cluster, and surrounding regionswere assessed on postoperative MRI and correlated with surgicaloutcome.Results: Fourteen of the 15 patients (93%) showed SISCOMhyperperfusion overlapping with the FDL. The FDL was detected onlyafter reevaluation of the MRI guided by the ictal SPECT in 7 of the 15patients (47%). Four distinct hyperperfusion patterns were observed,representing different degrees of seizure propagation. Nine patientshave been operated on. Five have been seizure-free since surgeryand one since a reoperation. The degree of resection of the MRIvisibleFDL was the major determinant of surgical outcome. Fullresection of the SISCOM hyperperfusion cluster was not required torender a patient seizure-free.Conclusion: Detailed analysis of SISCOM hyperperfusion patterns is apromising tool to detect subtle FDL on MRI and to establish theepileptic nature of these lesions noninvasively. Overlap between the41
Page 1: CYRURGIE2006
Page 4 and 5: Heelmeesters allerhande, verenig u!
Page 7: INHOUDSOPGAVEAbdominale Heelkunde 1
Page 10 and 11: De resultaten van een grote Noord-A
Page 12 and 13: VEGF (P = 0.008) correlate with a p
Page 14 and 15: severe ulcerative ileitis and jejun
Page 16 and 17: tekens op CT en/of MRI kunnen een b
Page 18 and 19: data we propose a scoring system in
Page 20 and 21: ABDOMINALETRANSPLANTATIECHIRURGIECA
Page 22 and 23: DYCKMANS K., LERUT E., GILLARD P.,
Page 24 and 25: LERUT J., ORLANDO G., ADAM R., SABB
Page 26 and 27: histopathologic diagnostic process.
Page 28 and 29: additional stimulants that the inna
Page 30 and 31: ARTIKELS UIT HETLEUVENSE NETCREVITS
Page 32 and 33: PRUYT M., DEVRIENDT D., VANNESTE A.
Page 34 and 35: BOSHOFF D., BUDTS W., MERTENS L., E
Page 36 and 37: FLAMENG W., MEURIS B., HERIJGERS P.
Page 38 and 39: prosthetic valve endocarditis who w
Page 40 and 41: in these patients We present a case
Page 42 and 43: SERCA2a. In SKO mice, gene-targeted
Page 44 and 45: MULTIDISCIPLINAIRBORSTCENTRUMMORALE
Page 46 and 47: east implant. Only two other cases
Page 50 and 51: SISCOM hyperperfusion cluster and M
Page 52 and 53: ONCOLOGISCHEHEELKUNDEBROUNS F., SCH
Page 54 and 55: infiltrative multilobular spindle c
Page 56 and 57: multivariable Cox model adjusted fo
Page 58 and 59: We retrospectively evaluated a surg
Page 60 and 61: We performed resection arthroplasty
Page 62 and 63: earing posterior-stabilised. To do
Page 64 and 65: age and key pinch strength. The dif
Page 66 and 67: FABRY K., LAMMENS J., DELHEY P., ST
Page 68 and 69: cases. The mean Knee Society’s kn
Page 70 and 71: short-term solution for his fractur
Page 72 and 73: the foot and result in major septic
Page 75 and 76: SAEGEMAN V., LISMONT D., VERDUYCKT
Page 77 and 78: Objective: The objective of this st
Page 79 and 80: VICTOR J., BELLEMANS J.: Physiologi
Page 81 and 82: skin construct displays authentic f
Page 83 and 84: Bewertung des Spenderdefektes ergab
Page 85 and 86: HIERNER R., BERGER A.: Options and
Page 87 and 88: vascularized ulnar nerve graft and
Page 89 and 90: cranial bone and dura which cannot
Page 91 and 92: defects.Adequate debridement, early
Page 93 and 94: Patients and Methods: Between 1995
Page 95 and 96: MASSAGE P., VANDENHOF B., VRANCKX J
Page 97 and 98: Background: High pressure injuries
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VERMEULEN P., DICKENS S., VRANCKX J
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inhibitors that neutralize the impa
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internship. These components repres
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Objective: To evaluate the expressi
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patients were diagnosed with acute
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Conclusions: This study demonstrate
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progressive accumulation of FVIII a
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his name to this condition through
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gevallen, beschouwen wij de minimaa
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Table 1Reperfusion time(min)PVR(dyn
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transplantation; dehiscence (n = 25
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upon reperfusion results from a red
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VAN DE WAUWER C., VAN RAEMDONCK D.E
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Bronchiolitis obliterans syndrome (
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noodzakelijk een beter inzicht te v
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patients of 70 years and older trea
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of debate. A good pain relief can b
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VAN GESTEL L., NIJS S., BROOS P.: T
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UROLOGIEALBERSEN M., JONIAU S., VAN
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children achieve bladder and bowel
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Results: Ninety-five percent of the
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esistant to degradation, but at 365
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Results: Although the surgery was m
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DE RIDDER D.: Conservatieve aanpak
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pressures were measured. The effect
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GOEMAN L., JONIAU S., OYEN R., VAN
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pelvic lymph node status were not w
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literature on nephron-sparing surge
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on overall survival was studied. Su
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materials, although it was architec
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Material und Methoden: Von 13 Zentr
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a remarkable higher number of forei
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VAN CALSTEREN K., VAN MENSEL K., JO
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VANDE WALLE J.G.J., BOGAERT G.A., M
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Introduction & Objectives: Control
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VAATHEELKUNDEBLADT O., MALEUX G., H
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FOURNEAU I., SABBE T., DAENENS K.,
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computed tomography (CT) and magnet
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We report an unusual case of a uret
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during GPIb stimulation, its activa
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2006 - UZ Leuven

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