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2006 - UZ Leuven

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the foot and result in major septic complications. Although no data areavailable on the effect of foot problems on function and quality of lifein patients with rheumatoid arthritis, in patients with diabetes mellitusthese scores drop substantially.MATRICALI G.A., DEREYMAEKER G.P.E., LUYTEN F.: Theposteromedial rim of the talar dome as the site for harvesting cartilagein the ankle: an anatomic study. Arthroscopy, <strong>2006</strong>; 22(11): 1241-1245.Purpose: The goal of this study was to determine whether a biopsyspecimen of a fixed size can be harvested reliably and consistently byarthroscopy at the posteromedial rim of the talar dome.Methods: A cartilage biopsy specimen was taken post mortemarthroscopically from the posteromedial rim of the talar dome in 20ankles. We aimed to take a full-thickness biopsy specimen of 10 x 5mm in size. The shape, length, width, position, and depth of thecreated defect were determined. Subsequently, 2 observers analyzedthe biopsy sites twice. The same set of parameters and the surfacearea of the lesion were determined. Differences between aimed andobserved sizes were studied.Results: In all ankles the aimed biopsy site could be seen andreached. The observed mean size of the biopsy specimens, whencompared with the aimed size, was only significantly different for themediolateral size. A wide variation of surface area was found. Nearlyall biopsy specimens started exactly at the posterior border of thedome, but they were somewhat more lateral than intended. In onlyhalf of the biopsy specimens was the shape linear or oval, the othersbeing rounded or irregular. In case a pre-existing posteromedialcartilage lesion was present, its position did not coincide with that ofthe biopsy specimen.Conclusions: A limited cartilage biopsy specimen could be harvestedreliably and consistently by arthroscopy at the posteromedial rim ofthe talar dome, although the size tended to be somewhat larger thanwe intended. Containment of a pre-existing posteromedial lesion wasnever jeopardized.Clinical relevance: A safe biopsy site for cartilage in the ankleeliminates donor-site morbidity in the knee and may improve thesuitability and biology of the obtained chondrocytes for successfulrepair of symptomatic joint surface defects of the ankle.64

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