2006 - UZ Leuven

VAATHEELKUNDEBLADT O., MALEUX G., HEYE S., VANBECKEVOORT D., NEVELSTEENA.: Progressive growth of a pelvic collection five years afterendovascular aneurysm repair: an atypical presentation of anasymptomatic contained rupture. J. Vasc. Surg., 2006; 43(1): 172-176.We report a case of an unusual and late presentation of anasymptomatic contained rupture after modular stent-graft implantationto treat an aortobiiliac aneurysm. Follow-up computed tomography(CT) scans 4 and 5 years after endovascular aneurysm repair showeda homogeneous, nonenhancing, but clearly growing, pelvic collection.CT-guided drainage of the collection was performed, and cultures ofthe evacuated brown fluid were negative for any infection. Control CTscan after drainage showed a complete collapse of both the collectionand the previously excluded iliac aneurysms. A direct communicationbetween the sterile pelvic collection and the excluded iliac aneurysmwas suggested on this CT imaging and confirmed afterwards bysurgery. From these imaging and surgical findings, this pelviccollection can be considered as an atypical presentation of anasymptomatic contained rupture of the excluded aneurysm.BONNEFOY A., DAENENS K., FEYS H.B., DE VOS R., VANDERVOORTP., VERMYLEN J., LAWLER J., HOYLAERTS M.F.: Thrombospondin-1controls vascular platelet recruitment and thrombus adherence in miceby protecting (sub)endothelial VWF from cleavage by ADAMTS-13.Blood, 2006; 107(3): 955-964.The function of thrombospondin-1 (TSP-1) in hemostasis wasinvestigated in wild-type (WT) and Tsp1-/- mice, via dynamic plateletinteraction studies with A23187-stimulated mesenteric endotheliumand with photochemically injured cecum subendothelium. Injectedcalcein-labeled WT platelets tethered or firmly adhered to almost allA23187-stimulated blood vessels of WT mice, but Tsp1-/- plateletstethered to 45% and adhered to 25.8% of stimulated Tsp1-/- vesselsonly. Stimulation generated temporary endothelium-associatedultralarge von Willebrand factor (VWF) multimers, triggering plateletstring formation in 48% of WT versus 20% of Tsp1-/- vessels. Injectionof human TSP-1 or thrombotic thrombocytopenic purpura (TTP)patient-derived neutralizing anti-ADAMTS13 antibodies corrected the161