Macrophages could be found deep in interstices 7.5 by 12.5 mum. Nodifference in collagen deposition and neovascularisation wasobserved. At 90 days time point, explants reconstructed with tighterwoven multifilament SPM were weaker than sutured or SPMMcontrols. Overall shrinkage of 10% was comparable for all groups.KONSTANTINOVIC M.L., POTTIER C., GUELINCKX I., SPELZINI F.,VERBEKEN E., DE RIDDER D., DE PREST J.: Reconstruction of thefascia with synthetic and biologic implant materials used inurogynecology. Int. J. Urogynaecol., <strong>2006</strong>; 17S (Abstract 001).Objectives: To compare inflammatory response, fibrosis process andbiomechanical properties of different materials already in use orproposed for augmentation of fascial repairs for genital prolapse.Materials and Methods: We experimentally compared two porcinecross-linked dermal collagen and two synthetic polypropylenecontaining implants: Pelvicol TM and Pelvisoft TM (Bard, Haasrode,Belgium), the latter a modification with large longitudinal slits;Pelvitex TM (Bard) as a novel collagen-coated monofilamentpolypropylene implant and Vypro II ® (Johnson and Johnson MedicalNV, Dilbeek, Belgium) lightweight mesh which is composed ofresorbable multifilament polyglactin 910 and synthetic monofilamentpolypropylene. The dermal collagen matrices are believed to induce amilder inflammatory response without compromising tensile strength.Implants were used to primarily repair a full thickness abdominal walldefect in 96 Wistar rats. Animals were sacrificed on day 7, 14, 30 and90 after implantation. At sacrifice the explant (implant and surroundinghost tissue) was evaluated for the presence of herniation, infection,erosion, adhesion formation and changes in size. Tensile strength wasassessed both on implants and explants. Histopathology wasperformed to evaluate collagen deposition and inflammatoryresponse. ED-1 antibody was used to identify rat macrophages.Results: While no herniations occurred, two clinical and two additionalpathololgy confirmed infections were observed, one in Pelvisoft andthree in the Pelvicol group. Pelvitex induced the least adhesion. At 90days Vypro II shrunk by 19% while the other materials did not shrink.At 90 d all materials could resist tensile forces of 16 N/cm (Pelvisoft),or higher (Pelvicol, Pelvitex and Vypro II; range 25-27 H/cm).Pelvisoft, with its open macroporous construct, had a lowertensiometric strength than Pelvico in the early postoperative phase at14 days. The acute inflammatory response was most pronounced inVypro II. The chronic inflammatory response and foreign body reactionwas comparable in both polypropylene containing materials but morepronounced compared to dermal matrices. Collagen deposition at theinterface between muscle and material was comparable for all148
materials, although it was architecturally more organised in thecollagen products.Conclusion: Pelvisoft has a lesser tensiometric resistance thanPelvicol on the short term, but not at 90 d, at what time all materialswere equally strong. Pelvitex has a slightly more attenuated acuteinflammatory reaction, with fewer adhesions than Vypro II. It didneither shrink. Vypro II induces most adhesions, shrinks by one fifthand induces the strongest acute inflammation.LERUT E., ROSKAMS T., JONIAU S., OYEN R., ACHTEN R., VANPOPPEL H., DEBIEC-RYCHTER M.: Metanephric adenoma duringpregnancy: clinical presentation, histology, and cytogenetics. HumanPathol., <strong>2006</strong>; 37(9): 1227-1232.Metanephric adenoma is a rare benign tumor of the kidney. It isconsidered to be derived from embryonic renal tissue and to be thebenign counterpart of the Wilms tumor. Although its imaging findingsand immunohistochemistry are nonspecific, it has a typicalmicroscopic morphology. We describe a case of a 24-year-oldprimigravida who presented in the 28th week of pregnancy with lowerback pain, fever, malaise, and anemia. At renal ultrasonography andmagnetic resonance imaging, a hemorrhagic tumor of 10 cm indiameter originating from the right kidney was seen. Based on theimaging findings, the diagnosis of a cystic renal cell carcinoma withrecent hemorrhage was suggested, and a radical nephrectomy wasperformed. Pathologic examination concluded to a metanephricadenoma. The further pregnancy went on well. The karyotype of thetumor was 46,XX,t(1;22)(q22;q13),t(15;16)(q21;p13). To ourknowledge, this is the first report on these chromosomal abnormalitiesin metanephric adenoma.MALKOWICZ S.B., VAN POPPEL H., MICKISCH G., PANSADORA V.,THOROFF J., SOLOWAY M., CHANG S., BENSON M., FUKUI I.: Muscleinvasiveurothelial carcinoma of the bladder. In: Bladder Tumors. Editors:Soloway M., Carmack A., Khoury S., <strong>2006</strong>: 221-237.Urothelial (transitional cell) carcinoma of the bladder is a significantneoplasm with over 55.000 new cases and 12.000 cancer-relateddeaths per year in the United States. It is the 5 th most common cancerin the USA and the 4 th leading cause of cancer deaths. The majority ofthese deaths are due to the effects of muscle-invasive disease, whichaccount for approximately one-third of the novo cases and are derivedfrom about 10% to 15% of preexisting cases of superficial disease.149
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CYRURGIE2006
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Heelmeesters allerhande, verenig u!
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INHOUDSOPGAVEAbdominale Heelkunde 1
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De resultaten van een grote Noord-A
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VEGF (P = 0.008) correlate with a p
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severe ulcerative ileitis and jejun
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tekens op CT en/of MRI kunnen een b
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data we propose a scoring system in
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ABDOMINALETRANSPLANTATIECHIRURGIECA
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DYCKMANS K., LERUT E., GILLARD P.,
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LERUT J., ORLANDO G., ADAM R., SABB
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histopathologic diagnostic process.
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additional stimulants that the inna
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ARTIKELS UIT HETLEUVENSE NETCREVITS
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PRUYT M., DEVRIENDT D., VANNESTE A.
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BOSHOFF D., BUDTS W., MERTENS L., E
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FLAMENG W., MEURIS B., HERIJGERS P.
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prosthetic valve endocarditis who w
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in these patients We present a case
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SERCA2a. In SKO mice, gene-targeted
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MULTIDISCIPLINAIRBORSTCENTRUMMORALE
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east implant. Only two other cases
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Object: Based on data from primate
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SISCOM hyperperfusion cluster and M
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ONCOLOGISCHEHEELKUNDEBROUNS F., SCH
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infiltrative multilobular spindle c
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multivariable Cox model adjusted fo
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We retrospectively evaluated a surg
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We performed resection arthroplasty
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earing posterior-stabilised. To do
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age and key pinch strength. The dif
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FABRY K., LAMMENS J., DELHEY P., ST
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cases. The mean Knee Society’s kn
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short-term solution for his fractur
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the foot and result in major septic
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SAEGEMAN V., LISMONT D., VERDUYCKT
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Objective: The objective of this st
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VICTOR J., BELLEMANS J.: Physiologi
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skin construct displays authentic f
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Bewertung des Spenderdefektes ergab
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HIERNER R., BERGER A.: Options and
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vascularized ulnar nerve graft and
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cranial bone and dura which cannot
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defects.Adequate debridement, early
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Patients and Methods: Between 1995
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MASSAGE P., VANDENHOF B., VRANCKX J
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Background: High pressure injuries
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VERMEULEN P., DICKENS S., VRANCKX J
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inhibitors that neutralize the impa
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internship. These components repres
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