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2006 - UZ Leuven

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multivariable Cox model adjusted for tumor thickness, ulceration, age,and sex, expression of MCM4 (hazard ratio [HR] of death = 4.04, 95%confidence interval [CI] = 1.39 to 11.76; P = .010) and MCM6 (HR ofdeath = 7.42, 95% CI = 1.99 to 27.64; P = .003) proteins was stillstatistically significantly associated with overall survival.Conclusion: We identified 254 genes whose expression wasassociated with metastatic dissemination of cutaneous melanomas.These genes may shed light on the molecular mechanisms underlyingpoor prognosis in melanoma patients.48

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