2006 - UZ Leuven

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VEGF (P = 0.008) correlate with a poor outcome, only CA IXexpression is an independent prognostic factor for overall survival andmetastasis-free survival.Conclusion: The difference in expression of CA IX and VEGF betweenintestinal- and diffuse-type adenocarcinomas may possibly explain thedifferent clinical behavior of these tumors. CA IX expression, ratherthan VEGF positivity in tumors, enables the identification of asubpopulation, characterized by a more aggressive behavior and apoorer prognosis.FA-SI-OEN P., VAN DE GENDER P., PUTTER H., ECTORS N., D’HOOREA., TOPAL B., PENNINCKX F.: The effect of polyethylene glycol andbutyrate on anastomotic healing in the rat colon. Tech. Coloproctol.,2006; 10(4): 308-311.Background: The use of mechanical bowel preparation is muchdebated.Methods: We evaluated the effects of polyethylene glycol (PEG), withor without a single dose of 3.0 mmol butyrate (BUT), on the burstingpressure (BP) of an intact colon segment and a colon anastomosis inrats. Also, histopathologic damage was studied.Results: In rats without colectomy, the mean BP was 159.2 mmHg(SD=18.9) after PEG treatment and 116.7 mmHg (SD=27.5) incontrols (p=0.001). In rats with colectomy, the mean BP was 90.4mmHg (SD=45.9) in the PEG group, 108.0 mmHg (SD=31.9) in theBUT group, and 102.7 mmHg (SD=44.7) in controls (p=0.44). Nosignificant differences in histopathologic scores were observedbetween rats treated with PEG and controls.Conclusions: PEG does not interfere with anastomotic healing in ratsas measured by BP. No benefit of a single dose of butyrate wasobserved.FERRANTE M., DE HERTOGH G., HLAVATY T., D’HAENS G.,PENNINCKX F., D’HOORE A., VERMEIRE S., RUTGEERTS P., GEBOESK., VAN ASSCHE G.: The value of myenteric plexitis to predict earlypostoperative Crohn’s disease recurrence. Gastroenterology, 2006;130(6): 1595-1606.Background & Aims: Early ileocolonoscopy allows detection ofrecurrence after surgically induced remission of Crohn's disease (CD).Unequivocal histologic markers predicting recurrence have not beenidentified. We assessed the predictive value of neural lesions for earlyendoscopic CD recurrence and long-term reintervention risk.4
Methods: Ileocolonic resection specimens from 59 patients with CDand 21 control patients were histologically scored for typicalinflammatory bowel disease lesions, neural hypertrophy, andpresence and severity of inflamed ganglia and nerve bundles.Endoscopic recurrence was determined at 3 months in all patients andat 1 year in 32 patients as part of 2 prospective clinical trials.Results: Myenteric plexitis of the proximal resection margin waspresent in 32 patients with CD (54%) in absence of surroundinginflammation. Patients with this feature had a higher endoscopicrecurrence (Rutgeerts score >/=2) at 3 months (75% vs 41%; oddsratio, 4.36; 95% confidence interval, 1.44-13.23; P = .008) and at 1year (93% vs 59%; odds ratio, 9.80; 95% confidence interval, 1.04-92.70; P = .041) and had a trend toward an earlier reintervention(mean, 7.00 vs 5.30 years; P = .174). The severity of myentericplexitis in the proximal resection margin correlated with the severity ofendoscopic recurrence at 3 months (r = 0.334, P = .010) and 1 year (r= 0.560, P = .001). Myenteric plexitis was the only consistent predictorof endoscopic recurrence.Conclusions: The presence of myenteric plexitis in proximal marginsof ileocolonic resection specimens is predictive of early endoscopicCD recurrence.FERRANTE M., DE HERTOGH G., PENNINCKX F., VAN ASSCHE G.:Protein-losing enteropathy in Crohn’s disease. Clin. Gastroenterol.Hepatol., 2006; 3(6): A 25.A 21-year-old man presented with pitting edema at both ankles,persisting hypoproteinemia, and iron-deficiency anemia, for which hehad been treated in another hospital with regular infusions of humanalbumin and iron sucrose. For the past 4 years, Crohn’s disease hadaffected his entire gastrointestinal tract and had been treated withaminosalicylates, prednisolone, oral budesonide, azathioprine,methotrexate, and, after exclusion of tuberculosis, infliximab. Atpresentation, he was on oral budesonide and he had nogastrointestinal symptoms. Blood analysis showed lymphopenia,hypoproteinemia with hypoalbuminemia, hypochromic anemia withpossible iron deficiency, and normal liver and kidney function withoutproteinuria on a urine sample.A stool collection after administration of 51 Cr-chloride-radiolabeledalbumin intravenously was used to confirm our hypothesis of proteinlosingenteropathy 1 ; 49% of the administered dose was found in a 4-day stool collection, suggestive of major protein loss in thegastrointestinal tract (normally < 1%). Magnetic resonanceangiography showed no large-vessel vasculitis. A radiologic bariumfollow-through performed 1 year earlier was reviewed and showed5
Page 1: CYRURGIE2006
Page 4 and 5: Heelmeesters allerhande, verenig u!
Page 7: INHOUDSOPGAVEAbdominale Heelkunde 1
Page 10 and 11: De resultaten van een grote Noord-A
Page 14 and 15: severe ulcerative ileitis and jejun
Page 16 and 17: tekens op CT en/of MRI kunnen een b
Page 18 and 19: data we propose a scoring system in
Page 20 and 21: ABDOMINALETRANSPLANTATIECHIRURGIECA
Page 22 and 23: DYCKMANS K., LERUT E., GILLARD P.,
Page 24 and 25: LERUT J., ORLANDO G., ADAM R., SABB
Page 26 and 27: histopathologic diagnostic process.
Page 28 and 29: additional stimulants that the inna
Page 30 and 31: ARTIKELS UIT HETLEUVENSE NETCREVITS
Page 32 and 33: PRUYT M., DEVRIENDT D., VANNESTE A.
Page 34 and 35: BOSHOFF D., BUDTS W., MERTENS L., E
Page 36 and 37: FLAMENG W., MEURIS B., HERIJGERS P.
Page 38 and 39: prosthetic valve endocarditis who w
Page 40 and 41: in these patients We present a case
Page 42 and 43: SERCA2a. In SKO mice, gene-targeted
Page 44 and 45: MULTIDISCIPLINAIRBORSTCENTRUMMORALE
Page 46 and 47: east implant. Only two other cases
Page 48 and 49: Object: Based on data from primate
Page 50 and 51: SISCOM hyperperfusion cluster and M
Page 52 and 53: ONCOLOGISCHEHEELKUNDEBROUNS F., SCH
Page 54 and 55: infiltrative multilobular spindle c
Page 56 and 57: multivariable Cox model adjusted fo
Page 58 and 59: We retrospectively evaluated a surg
Page 60 and 61: We performed resection arthroplasty
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earing posterior-stabilised. To do
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age and key pinch strength. The dif
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FABRY K., LAMMENS J., DELHEY P., ST
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cases. The mean Knee Society’s kn
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short-term solution for his fractur
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the foot and result in major septic
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SAEGEMAN V., LISMONT D., VERDUYCKT
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Objective: The objective of this st
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VICTOR J., BELLEMANS J.: Physiologi
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skin construct displays authentic f
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Bewertung des Spenderdefektes ergab
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HIERNER R., BERGER A.: Options and
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vascularized ulnar nerve graft and
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cranial bone and dura which cannot
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defects.Adequate debridement, early
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Patients and Methods: Between 1995
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MASSAGE P., VANDENHOF B., VRANCKX J
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Background: High pressure injuries
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VERMEULEN P., DICKENS S., VRANCKX J
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inhibitors that neutralize the impa
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internship. These components repres
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Objective: To evaluate the expressi
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patients were diagnosed with acute
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Conclusions: This study demonstrate
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progressive accumulation of FVIII a
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his name to this condition through
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gevallen, beschouwen wij de minimaa
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Table 1Reperfusion time(min)PVR(dyn
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transplantation; dehiscence (n = 25
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upon reperfusion results from a red
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VAN DE WAUWER C., VAN RAEMDONCK D.E
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Bronchiolitis obliterans syndrome (
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noodzakelijk een beter inzicht te v
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patients of 70 years and older trea
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of debate. A good pain relief can b
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VAN GESTEL L., NIJS S., BROOS P.: T
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UROLOGIEALBERSEN M., JONIAU S., VAN
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children achieve bladder and bowel
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Results: Ninety-five percent of the
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esistant to degradation, but at 365
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Results: Although the surgery was m
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DE RIDDER D.: Conservatieve aanpak
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pressures were measured. The effect
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GOEMAN L., JONIAU S., OYEN R., VAN
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pelvic lymph node status were not w
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literature on nephron-sparing surge
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on overall survival was studied. Su
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materials, although it was architec
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Material und Methoden: Von 13 Zentr
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a remarkable higher number of forei
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VAN CALSTEREN K., VAN MENSEL K., JO
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VANDE WALLE J.G.J., BOGAERT G.A., M
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Introduction & Objectives: Control
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VAATHEELKUNDEBLADT O., MALEUX G., H
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FOURNEAU I., SABBE T., DAENENS K.,
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computed tomography (CT) and magnet
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We report an unusual case of a uret
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during GPIb stimulation, its activa
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2006 - UZ Leuven

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