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NASA Scientific and Technical Aerospace Reports

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20040073586 Department of the Army, Washington, DC<br />

The Physiologic Effects of Wounds, Surgery in World War II (Medical Department, USA Army)<br />

Jan. 1952; 385 pp.; In English; Original contains color illustrations<br />

Report No.(s): AD-A422425; No Copyright; Avail: CASI; A17, Hardcopy<br />

The volumes comprising the history of the Medical Department of the U. S. Army in World War II are divided into two<br />

series: (1) The Administrative <strong>and</strong> Operational series which constitutes a part of the general series of the history of the U. S.<br />

Army in World War 11, published under the direction of the Office of the Chief of Military History, <strong>and</strong> (2) the Professional,<br />

or clinical <strong>and</strong> technical series, published as The Medical Department of the USA Army under the direction of the Office of<br />

The Surgeon General. Both series are being prepared by the Historical Unit, Army Medical Service. This volume is one of<br />

a number of surgical volumes to be published in the latter series.<br />

DTIC<br />

Medical Services; Military Operations; Physiological Effects; Surgery; United States<br />

20040073607 Army Research Inst. of Environmental Medicine, Natick, MA<br />

Characterization of Uncertainties in a Thermal Strain Prediction Model for Military Applications<br />

Yokota, Miyo; Matthew, William T.; Berglund, Larry G.; Buller, Mark J.; Hoyt, Reed W.; Dec. 2003; 38 pp.; In English<br />

Report No.(s): AD-A422466; USARIEM-T04-03; No Copyright; Avail: CASI; A03, Hardcopy<br />

Thermoregulatory prediction models are increasingly needed for accurate physiological status <strong>and</strong> risk assessment to<br />

prevent heat <strong>and</strong> cold injuries among deployed soldiers. These biophysical prediction models can provide consistent <strong>and</strong><br />

repeatable simulations over a wide range of working <strong>and</strong> environmental conditions to assess physiological risks because they<br />

are rationally based on thermodynamics <strong>and</strong> heat transfer coupled with active physiological control systems <strong>and</strong> biophysical<br />

properties. In contrast, a statistical regression prediction model (8) is limited to the test conditions used in its development.<br />

However, it is important to evaluate model predictions of physiological responses in real field situations for its acceptance <strong>and</strong><br />

useful application. Recent improvements in physiological data collection methods, physiological sensors <strong>and</strong> communication<br />

devices have facilitated the military field evaluation process. Comparisons of physiological data with model predictions<br />

provide the analytical basis needed to identify uncertainties <strong>and</strong> characterize model performance.<br />

DTIC<br />

Mathematical Models; Military Technology; Physiological Effects<br />

20040073615 Tulane Univ., New Orleans, LA<br />

Involvement of a Human Endogenous Retrovirus in Breast Cancer<br />

Garry, Robert F.; Aug. 2003; 101 pp.; In English; Original contains color illustrations<br />

Contract(s)/Grant(s): DAMD17-00-1-0472<br />

Report No.(s): AD-A422489; No Copyright; Avail: CASI; A06, Hardcopy<br />

Our overall goal is to determine whether human mammary tumor virus (HMTV) sequences, present as an endogenous<br />

retrovirus, are involved in a subset of human breast cancers. In studies completed for first specific aim, samples form a cohort<br />

(&gt;200) of breast cancer <strong>and</strong> appropriate control patients were obtained. Tn studies under the second specific aim, we<br />

identified <strong>and</strong> sequenced HMTV nucleic acids in breast cancer tissue, control tissue, <strong>and</strong> blood of patients form our cohorts.<br />

Results form a subset of blinded blood samples found that blood from approximately 20% of controls <strong>and</strong> 70% of breast cancer<br />

patients were positive for HMTV sequences. The third specific aim was to construct DNA <strong>and</strong> CDNA libraries from tissues<br />

positive for HNTV proviurses. As this task ahs been accomplished by others (Pogo <strong>and</strong> Mason), we are focused on confirming<br />

the blinded PCR results in the entire cohort, which is nearly completed. The studies under specific aim four, to express HMTV<br />

proteins in an insect cell system, <strong>and</strong> to characterize the immunological reactions of breast cancer patients <strong>and</strong> controls against<br />

HMTV proteins, are in progress. If a definite link is established, HMTV will provide a target for vaccine development <strong>and</strong><br />

breast cancer therapy.<br />

DTIC<br />

Cancer; Mammary Gl<strong>and</strong>s<br />

20040073638 Navy Personnel Research Studies <strong>and</strong> Technology, Millington, TN<br />

Pregnancy <strong>and</strong> Parenthood: Results of the 2001 Survey<br />

Uriell, Zannette A.; Apr. 2004; 78 pp.; In English<br />

Report No.(s): AD-A422521; NPRST-AB-04-3; No Copyright; Avail: CASI; A05, Hardcopy<br />

The 2001 Survey of Pregnancy <strong>and</strong> Parenthood is the sixth in a series of Navy-wide surveys that began in 1988. A<br />

166

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