NASA Scientific and Technical Aerospace Reports

endothelial cells; and 2) determine tumor cell mediated changes in Adriamycin transport across endothelial cells. Experiments
performed to address aim 1 revealed no tumor mediated increases in p-gp protein (a classic multi-drug resistance protein) in
endothelial cells.
DTIC
Cancer; Mammary Glands; Tumors
20040073789 Congressional Budget Office, Washington, DC
A CBO PAPER: Financing Long-Term Care for the Elderly
Apr. 2004; 55 pp.; In English
Report No.(s): AD-A422772; No Copyright; Avail: CASI; A04, Hardcopy
Over the next several decades, the population of U. S. seniors-people aged 65 and older is expected to grow rapidly, more
than doubling by 2040 while the population as a whole grows by about one-third. That surge will probably produce a similar
increase in the demand for long-term care (LTC) services-the personal assistance that enables people who are impaired to
perform daily routines such as eating, bathing, and dressing. Today, seniors finance such services from a variety of sources,
including personal savings, care donated by friends and family, private insurance, and public programs such as Medicaid and
Medicare. This Congressional Budget Office (CBO) paper-prepared at the request of the House Budget Committeesummarizes
the current state of financing for long- term care, identifies some of the issues affecting it both now and in the
future, and considers policy alternatives that address the mix of private and governmental sources of financing for LTC costs.
In keeping with CBO’s mandate to provide objective, impartial analysis, this report contains no recommendations. Stuart
Hagen of CBO’s Health and Human Resources Division prepared the paper under the supervision of Steve Lieberman and
James Baumgardner.
DTIC
Age Factor; Management Planning; Medical Services
20040073790 Utah State Univ., Logan, UT
Development of Laulimalide-Based Microtubule- Stabilizing Agents: New Chemistry for the Treatment of Breast
Cancer
Davidson, Bradley S.; Jul. 2003; 8 pp.; In English
Contract(s)/Grant(s): DAMD17-00-1-0480
Report No.(s): AD-A422773; No Copyright; Avail: CASI; A02, Hardcopy
Through a collaborative research program involving Utah State University and the Cancer Research Center of Hawaii,
we have discovered that the sponge-derived macrolides laulimalide and isolaulimalide are potent cytotoxins with
paclitaxel-like antimicronibule-stabilizing activity. Laulimalide is a potent inhibitor of cellular proliferation with an IC50 in
the low nanomolar range and it maintains activity against a drug resistant, P-glycoprotein over- expressing ovarian cancer cell
line. Laulimalide represents a lead compound for new class of microtubule-stabilizing agents with activities that may prove
therapeutically useful for the treatment of breast cancer. The aim of this project is to utilize a combinatorial solid-phase
synthetic approach for the construction of a library of laulimalide analogs for structure activity relationship (SAR) studies. In
an effort to discover a new chemotherapeutic agent for the treatment of breast cancer we propose to do the following: I)
transfer our current solution-phase synthetic approach to solid phase, 2) using a split and pool strategy, prepare 260 laulimalide
analogs, 3) test laulimalide analogs for microtubule-stabilizing activity, cytotoxicity against both drug-sensitive and
drug-resistant breast cell lines, and 4) submit active analogs to the NCI for screening in the 60-cell line. Work to-date has been
concentrated on the adaptation of our solution phase laulimalide synthetic methods for efficient conversion to the solid phase.
Because of difficulties adding fragment C, a new retrosynthetic approach has been developed and is now being explored. It
has the advantage that the coupling of fragment C to the resin-bound material will not involve the formation of a new
asymmetric center, thus simplifying the reaction. Fragment B analogs have been prepared and coupled using a Juliea-
Kocienski type reaction to an appropriate aldehyde and the first two laulimalide analogs have been screened for biological
activity.
DTIC
Cancer; Mammary Glands; Stabilization
20040073791 California Univ., Los Angeles, CA
The UCLA-Community Breast Cancer Collaborative Clinical Translational Research Program
Glaspy, John A.; Oct. 2003; 7 pp.; In English
Contract(s)/Grant(s): DAMD17-01-1-0180
Report No.(s): AD-A422777; No Copyright; Avail: CASI; A02, Hardcopy
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