NASA Scientific and Technical Aerospace Reports

meeting or exceeding their caloric intake goals. In conclusion, we are making good progress toward completion of this study.
DTIC
Aerobes; Circulation; Diets; Estrogens; Exercise Physiology; Females; Menstruation; Physical Exercise
20040073768 Wright State Univ., Dayton, OH
Low Level Chemical Toxicity: Relevance to Chemical Agent Defense
Morris, Mariana; Jul. 2003; 134 pp.; In English
Contract(s)/Grant(s): DAMD17-00-C-0020
Report No.(s): AD-A422716; No Copyright; Avail: CASI; A07, Hardcopy
A multidisciplinary project is underway to study the influence of low-level exposure to chemicals to which military
personnel had contact during the Persian Gulf War. The research group includes investigator with expertise in neuroscience,
molecular biology, enzymology, cardiovascular physiology and neuropharmacology. The overall objectives is to study the
effect of chemical exposure from the single cell/gene level to the whole animal and ending with the human condition. Results
include but are not limited to: proteomic changes have been identified that are different between pyridostigmine bromide and
physostigmine; spectral analysis has showed dramatic alterations in heart rate variability and baroreflex index in mice
challenged with stress and/or pyridostigmine; sarin and noise stress and also pyridostigmine bromide and DEET with noise
stress induce significant decreases in electron transfer rates compared to noise stress alone, factors have been identified which
will increase the reliability of correlations between enzymatic analyses and abnormal or disease states; modest gene expression
changes have been determined using Mann-Whitney tests after eliminating those genes with expression levels that appear to
represent inactive genes.
DTIC
Chemical Defense; Chemical Warfare
20040073772 Minnesota Univ., Minneapolis, MN
Metabolizing Enzyme 1 Polymorphisms and Prognosis Among Women Treated with Breast Cancer
Sweeney, Carol; Oct. 2003; 7 pp.; In English
Contract(s)/Grant(s): DAMD17-01-1-0128
Report No.(s): AD-A422722; No Copyright; Avail: CASI; A02, Hardcopy
This study will use archived tissue and data to examine survival of women treated for breast cancer in relation to inherited
polymorphisms of drug metabolizing enzymes. During year 1, we completed compilation of tumor registry data for eligible
subjects (Task 1 of the approved Statement of Work) and study start-up tasks, including IRB review, hiring study staff, creating
data collection forms, establishing a study database, and training study staff on data collection procedures. Collection of tissue
samples (Task 2 of the approved Statement of Work) has proceeded during year 2, including obtaining pathology slides and
blocks, review of slides by the study pathologist, and abstracting information from pathology reports into the study database.
As described in the statement of work, data collection tasks will continue into years 2 and 3, 50 no reportable scientific results
are available at the end of year 2.
DTIC
Cancer; Enzymes; Females; Mammary Glands; Metabolism; Polymorphism; Prognosis; Tissues (Biology)
20040073784 Virginia Univ., Charlottesville, VA
Increasing Oxygen Consumption During Shock
Gainer, John L.; May 4, 2004; 9 pp.; In English
Contract(s)/Grant(s): N00014-95-1-0213
Report No.(s): AD-A422762; No Copyright; Avail: CASI; A02, Hardcopy
Whole-body oxygen consumption is decreased after hemorrhage. Typical methods for increasing oxygen consumption
have involved increasing the blood oxygen concentration using enriched oxygen gases, hemoglobins and fluorocarbon
compounds; however, clinical trials involving these have not been totally successful. Increasing the oxygen concentration
increases its diffusion rate through blood plasma; however, an alternative method would be to increase the diffusion coefficient
of oxygen itself. This was shown to be possible using a naturally- occurring compound called crocetin. Crocetin also increased
whole-body oxygen consumption in hemorrhaged rats and resulted in an increased survival rate. However, this occurred over
a relatively small concentration range. Thus, trans sodium crocetinate (TSC) was developed, which also increases oxygen
consumption in rats after hemorrhage and increases survival. TSC has also been shown to increase blood pressure and to
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