Behavioral Science

Mood Disorders 97
Table 13.2 Other Antidepressants Indicated for the Treatment of Depression (Continued )
Generic Brand Mechanism Side
Name Name of Action Effects Other
Venlafaxine Effexor Serotonin and Nausea, Can increase
norepinephrine dizziness, blood pressure
reuptake
sexual
inhibitor, also dysfunction,
inhibitor of headache,
dopamine and dry
reuptake at mouth
high doses
Duloxetine Cymbalta Similar to Nausea, dry Also indicated
venlafaxine mouth, for neuropathic
constipation, pain
diarrhea,
dizziness,
and
insomnia
What are tricyclic antidepressants
(TCAs)?
Why are tricyclics a second-line
treatment option?
What are the side effects of tricyclic
antidepressants?
Older antidepressants (also known as
heterocyclics) are currently considered
a second-line treatment option.
Greater side effects and lethality in
overdose
Anticholinergic effects: dry mouth,
blurred vision, constipation, and
confusion
Alpha-blocking effects: sedation also
caused by antihistaminic effects,
orthostatic hypotension, and cardiac
arrhythmias
May lower the seizure threshold
Are contraindicated in glaucoma
Must be used with caution in urinary
retention