Behavioral Science
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146 Deja Review: <strong>Behavioral</strong> <strong>Science</strong><br />
What is the difference between strong<br />
and partial agonists?<br />
What is the difference between opiates<br />
and opioids?<br />
How do kappa and mu receptors differ?<br />
Which opioids/opiates are strong<br />
mu receptor agonists?<br />
Which opioids/opiates are partial<br />
mu receptor agonists?<br />
What relative of morphine without<br />
sedative effect is used to suppress<br />
cough?<br />
Which opioids/opiates are mu receptor<br />
antagonists?<br />
Which opioids/opiates are kappa<br />
receptor antagonists?<br />
What drug can be used as a narcotic<br />
reversal agent?<br />
Which opioids/opiates are metabolized<br />
by CYP2D6?<br />
Both strong and partial agonists have<br />
high affinity for the receptor; but unlike<br />
strong agonists, partial agonists have<br />
low efficacy to activate the receptor<br />
resulting in a weak effect. Because of<br />
this high affinity/low efficacy, they can<br />
antagonize/block the effects of a<br />
stronger agonist.<br />
Opiates are derived from the<br />
opium poppy, while opioids<br />
are synthetic or semisynthetic<br />
derivatives of opiates.<br />
The difference between kappa receptors<br />
and mu receptors is that activation of<br />
kappa receptors produces less analgesia,<br />
less respiratory depression/asphyxia<br />
(floor effect), and produce dysphoria<br />
instead of euphoria.<br />
Morphine<br />
Fentanyl<br />
Etorphine<br />
Heroin<br />
Hydromorphone<br />
Oxycodone<br />
Meperidine<br />
Buprenorphine<br />
Pentazocine<br />
Dextromethorphan<br />
Nalorphine<br />
Naltrexone (nonnarcotic)<br />
Buprenorphine<br />
Naltrexone (nonnarcotic)<br />
Naltrexone/Naloxone (aka Narcan)<br />
Oxycodone<br />
Codeine
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