Behavioral Science

170 Deja Review: Behavioral Science
Which tricyclic is the least likely
to cause orthostatic hypertension?
What is the most common indication
for MAOIs (monoamine oxidase
inhibitors)?
What is the mechanism of action
of MAOIs?
What are the names of commonly
prescribed MAOIs?
What are the common side effects
of MAOIs
What other medication must be avoided
in patients taking MAOIs?
What other substance must be avoided
by patients taking MAOIs?
What MAO inhibitor is now available
in a transdermal patch which does not
require a change in diet?
What are some pharmacologic agents
that can cause psychosis?
Nortriptyline
Treatment of atypical depression
(depression with increased sleep,
appetite, and leaden paralysis)
They work by inhibiting the
mitochondrial enzyme monoamine
oxidase which metabolizes
norepinephrine, serotonin, and
dopamine, resulting in a buildup
of these biogenic amines and their
subsequent leakage into the
synapse.
Selegiline
Phenelzine
Tranylcypromine
Sedation
Anticholinergic effects
Orthostatic hypotension
Cardiac conduction disturbances
Stimulants and pseudoephedrine must
be avoided because they can cause
hypertensive crisis.
Tyramine, which is found in aged
cheeses, beer, certain meats and fish,
fava beans, red wine (particularly
Chianti), avocados, chocolate,
and dairy products. Signs of
tyramine ingestions include
headache, arrhythmias, and
hypertensive crisis.
Selegiline, which is also useful for
patients who cannot swallow oral
medicines
Amphetamines
Cocaine
L-Dopa