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Brian P. Jacob, David C. Chen, Bruce Ramshaw, Shirin Towfigh (eds.) - The SAGES Manual of Groin Pain-Springer International Publishing (2016)

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196<br />

B.J. Dunkin<br />

Table 14.1. Summary <strong>of</strong> analgesics for multimodal pain therapy.<br />

Agent Mode <strong>of</strong> Action Dose Safety<br />

Local<br />

anesthetics<br />

Nerve conduction<br />

blockade<br />

Ropivacaine 0.2 %<br />

infiltration<br />

Bupivacaine 0.1–0.25 %<br />

infiltration<br />

Bupivacaine liposome<br />

injectable suspension<br />

(EXPAREL) 1.3 %<br />

infiltration<br />

NSAIDs COX-2 inhibition IV: ketorolac<br />

15–30 mg q6 h<br />

PO: celecoxib 200 mg<br />

BID<br />

Gabapentinoids<br />

α-agonists<br />

(Clonidine)<br />

Acetaminophen<br />

(APAP)<br />

Opioids<br />

Ketamine<br />

α2δ ion channel<br />

blockade<br />

Enhanced<br />

monoaminemediated<br />

analgesia<br />

GABA inhibition,<br />

serotonergic<br />

interaction<br />

Gabapentin 600 mg po<br />

TID<br />

Pregabalin 100 mg po<br />

BID<br />

Patch: 0.1 mg/24 h<br />

PO: 650 mg q6 h<br />

IV: 1000 mg q6 h<br />

μ-receptor agonist Varied depending on<br />

formulation<br />

Nonselective<br />

NMDA<br />

antagonism<br />

Neurotoxicity<br />

and<br />

cardiotoxicity<br />

Wound site and<br />

GI bleeding a ,<br />

renal toxicity b<br />

Sedation<br />

c<br />

Hypotension and<br />

bradycardia<br />

Hepatotoxicity<br />

Sedation,<br />

hypotension,<br />

respiratory<br />

depression,<br />

nausea<br />

1 mg/kg/h infusion Hallucinations,<br />

confusion<br />

a<br />

Ketorolac should not be administered preoperatively<br />

b<br />

More selective COX-2 inhibitors like celecoxib are associated with lower incidence<br />

<strong>of</strong> these complications<br />

c<br />

Adjust carefully in renal failure patients<br />

tissue to block nerves locally, regionally to block pain perception from<br />

an area <strong>of</strong> the body, or around the spinal cord to block transmission <strong>of</strong><br />

pain signals to the brain. <strong>The</strong>y may also be short acting (lidocaine:<br />

1–2 h duration), intermediate acting (bupivacaine: 3–6 h duration), or<br />

long acting (liposomal bupivacaine: 72 h duration). Local anesthetics<br />

may also be continuously pumped into the surgical site using an elastomeric<br />

or electrical pump in an effort to prolong the duration <strong>of</strong> their

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