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Brian P. Jacob, David C. Chen, Bruce Ramshaw, Shirin Towfigh (eds.) - The SAGES Manual of Groin Pain-Springer International Publishing (2016)

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366<br />

D.S. Edelman<br />

Table 27.1. Bioactive prosthetic materials.<br />

Crosslinking<br />

Sterilization<br />

Mesh name Vendor Source<br />

®<br />

AlloDerm LifeCell Human dermis No None<br />

®<br />

AlloMax Bard/Davol Human dermis No Gamma irradiation<br />

CollaMend Bard/Davol Porcine dermis Yes Ethylene oxide<br />

FlexHD Ethicon Human dermis No None<br />

FortaGen ® Organogenesis Porcine intestine Yes Gamma irradiation<br />

®<br />

MatriStem ACell Porcine bladder No E-beam<br />

®<br />

Peri-Guard Synovis Bovine pericardium Yes Liquid alcohol<br />

Permacol Covidien Porcine dermis Yes Gamma irradiation<br />

®<br />

Strattice LifeCell Porcine dermis No E-beam<br />

®<br />

SurgiMend TEI Biosciences Fetal bovine dermis No Ethylene oxide<br />

®<br />

Surgisis Cook Medical Porcine intestine No Ethylene oxide<br />

Tutopatch ® Tutogen Medical Bovine pericardium No Gamma irradiation<br />

®<br />

Veritas Synovis Bovine pericardium No E-beam<br />

®<br />

XenMatrix Bard/Davol Porcine dermis No E-beam<br />

Introduction<br />

<strong>The</strong> use <strong>of</strong> mesh in the repair <strong>of</strong> hernias is commonplace. Synthetic<br />

meshes such as polypropylene and polyester have been the standard for<br />

hernia repairs since the 1980s. Biologic graft material composed <strong>of</strong> purified<br />

porcine small intestinal submucosa was first introduced to the<br />

United States in 1998, as an alternative to synthetic biomaterials. <strong>The</strong>se<br />

meshes, composed <strong>of</strong> extracellular matrix (ECM) collagen, fibronectin,<br />

associated glycosaminoglycans, and growth factors [ 1 – 4 ], have been<br />

extensively investigated in animal models [ 5 – 7 ] and used clinically in<br />

many types <strong>of</strong> surgical procedures. Referred to as bioactive prosthetic<br />

materials ( BPM ) , they are considered a scaffold for the binding <strong>of</strong><br />

growth factors and other cellular elements for the healing response. <strong>The</strong><br />

subsequent healing response and strength are dependent on ingrowth<br />

from the patient’s cells and blood vessels into the ECM <strong>of</strong> the<br />

BPM. Fibrin may assist this ingrowth and thus may be added extrinsically<br />

as topical fibrin sealant [ 8 ]. <strong>The</strong> balance between ECM synthesis<br />

and degradation contributes to the ultimate success <strong>of</strong> the hernia repair.<br />

Surgisis (Cook Surgical, Bloomington, IN) was the first biologic<br />

graft material to be marketed in the United States. I began using it in my<br />

practice for hernia repairs and reported my initial results in Surgical

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