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12 th Congress of the European Hematology Association presence of at least two of the following: 1) anemia (hemoglobin
plete remission or recurrent disease after previous chemotherapy. ESHAOx consisted of E, 40 mg/m 2 on days 1 to 4; S, 500 mg on days 1 to 5; HA, 2 g/m 2 on day 5; and Ox, 130 mg/m 2 on day 1, every 3 weeks. Eligible patients were scheduled to receive a maximum of 6 cycles, and high dose chemotherapy and hematopoietic stem cell rescue allowed. Responses were evaluated every 3 cycles. All patients gave written informed consent before study entry. Results. Between May 2006 and January 2007, 27 patients were enrolled. Nineteen (70%) patients with relapsed, 8 patients with refractory, and 10 (37%) patients with IPI 3-5 were included in this study. Twenty patients were evaluable for response with 7 ongoing and 26 for toxicity. A total of 61 cycles were administered for a median number of 2 (range 1-5) per patient. There were 4 (20%) complete responses and 6 (30%) partial responses, producing an overall response rate of 50% (95% CI, 28-72%). Most common grade 3/4 toxicity of the courses was myelosuppression with including neutropenia (39%) and thrombocytopenia (20%). There was one therapy-related death due to neutropenic sepsis. Non-hematologic toxicity was very favorable. Conclusions. The preliminary results of ESHAOx combination showed antitumor activity and favorable toxicity profile, suggesting it can be used as salvage regimen for relapsed/refractory aggressive NHL patients. 0721 LONG-TERM SURVIVAL OF A BROAD AGE POPULATION OF PATIENTS WITH MANTLE CELL LYMPHOMA AFTER FRONTLINE HIGH DOSE SEQUENTIAL CHEMOTHERAPY WITH RITUX- IMAB AND AUTOLOGOUS STEM CELL TRANSPLANTATION S. Cortelazzo, 1 A. Billio, 2 M. Magni, 3 A. Rossi, 2 M. Pintimalli, 2 M. Marchesi, 4 M. Zanni, 4 M. Mian, 2 C. Tarella4 M. Boccadoro, 4 A. Andreini, 4 F. Benedetti, 4 G. Pizzolo, 4 M. Gianni, 3 A. Rambaldi2 1 Hematology BZ, BOLZANO; 2 Division of Hematology, BOLZANO; 3 Chair of Oncology, MILAN; 4 Chair of Hematology, TURIN, Italy Intensive therapeutic programs improve the clinical outcome of MCL, but are toxic in elderly patients and did not prevent the continuous relapse rate. The aim of the present study was to evaluate if an up-front Rituximab supplemented and age-adapted high-dose sequential chemotherapy (R-HDS) supported by ASCT can improve the survival of a broad age population with disseminated MCL. From. 1992 to 2005, 54 patients (pts) 60 years (group 2) were enrolled in the study. The majority of both groups had an advanced stage, bone marrow infiltration and >1 IPI risk factors. Group 1 received standard R-HDS including: HD-cyclophosphamide (CTX) 7 gr/sqm and HD-Ara-C (2 g/sqm every 12 hours for 6 days), followed by HDS HDmelphalan (180 mg/sqm) and/or HD-mitoxantrone plus melphalan (60 and 180 mg/sqm) and ASCT. Rituximab (375 mg /sqm) was given for a total of 6 doses, twice after HD-CTX and HD-Ara-C, as in vivo purging before CD34 + cells harvest and twice after ASCT. Elderly patients received an age-adapted R-HDS: HD-CTX (3-4 gr/sqm) and HD-Ara-C (1-1.5 g/sqm every 12 hours for 3-5 days), followed by HD-melphalan (120 mg/sqm) and HD-mitoxantrone plus melphalan (40 and 120 mg/sqm). 35 pts (65%) in group 1 and 9 (47%) in group 2 completed the planned program. After ASCT the CR rate was 89% in young and 95% in elderly patients and the treatment-related mortality was 4%. With a median follow-up of 43 months (range 6-101) in group 1 and 30 months (range 9-68) in group 2, the 5-year estimated OS, EFS and DFS were respectively 77%, 71% and 72%, in group 1 and 58%, 56% and not yet achieved in group 2. We conclude that R-HDS produces long-term remissions with a manageable toxicity also in elderly pts with advanced stage MCL. 0722 MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA IN PATIENTS WITH HUMAN IMMUNODEFICIENCY VIRUS INFECTION E. Boulanger, 1 V. Meignin, 1 M. Baia, 2 V. Molinier-Frenkel, 2 K. Leroy, 2 J.C. Delchier, 2 M. Bentata, 3 C. Goujard, 4 D. Salmon, 5 M.A. Valantin, 6 Y. Levy, 2 E. Oksenhendler, 1 L. Gerard, 1 C. Copie-Bergman2 1 Hopital Saint Louis, PARIS; 2 Hopital Henri Mondor, CRETEIL; 3 Hopital Avicenne, BOBIGNY; 4 Hopital Bicetre, LE KREMLIN BICETRE; 5 Hopital Cochin, PARIS; 6 Hopital Pitie-Salpetriere, PARIS, France Background. In Human Immunodeficiency Virus (HIV)-infected patients, the risk of non-Hodgkin lymphoma is significantly increased compared to the general population. However, mucosa-associated lymphoid tissue (MALT) lymphomas have been only occasionally reported during the setting of HIV infection. Aims. To describe the features of a retrospective series of 8 HIV-infected patients affected with MALT lymphoma. Methods. Morphological and immunohistochemical analyses including BCL10 immunostaining, were performed, as well as in situ hybridization for Epstein-Barr virus-encoded RNA (EBER) detection, fluorescence in situ hybridization (FISH) analyses with MALT1, immunoglobulin heavy chain (IGH) and BCL10 probes, PCR detection of monoclonal IGH gene rearrangements and RT-PCR detection of API2- MALT1 chimeric transcript resulting from the t(11;18)(q21;q21) translocation. Results. Four men and four women with a median age of 42 years (range, 35-67) were included. Six patients were infected with HIV-1, one with HIV-2 and one with HIV-O. Upon lymphoma diagnosis, 5 patients were receiving antiretroviral treatment, consisting of a highly active antiretroviral therapy (HAART) in 2 cases. The median CD4 + cell count was 191×10 6 /L (range, 44-640), and the plasma HIV RNA load, available in 7 cases, ranged from undetectable to 351,516 copies/mL (median, 8,813 copies/mL). One patient had a salivary gland lymphoma, and 7 had a gastric lymphoma, concomitant in one case with a pulmonary involvement. Disease stage was IE in 4 cases, IIE in 2 cases, and IV in the 2 others. Histological analyses of tumour samples displayed typical features of MALT lymphoma in all cases, with focal transformation into diffuse large B-cell lymphoma (DLBCL) in 2 cases. Concomitant Helicobacter pylori (Hp) infection of the stomach was found in 6 cases, including 5 patients with a gastric lymphoma. Immunohistochemistry showed a nuclear expression of BCL10 in the 5 studied cases. Three cases were found to be EBERnegative, whereas less than 1% EBER + cells were detected in 4 cases. A monoclonal rearrangement of IGH gene was detected in 4 cases out of 6 analyzed. RT-PCR and/or FISH analysis performed in 7 cases, displayed the presence of t(11;18) translocation in one case. Treatment for lymphoma consisted of Hp eradication therapy in the 5 patients with a Hpassociated gastric MALT lymphoma. Four of them achieved a complete remission (CR) whereas the disease remained stable in one patient, due to Hp resistance to 4 lines of antibiotic treatment. Partial gastrectomy followed by CHOP-derived chemotherapy was performed in one case with focal DLBCL. Surgical resection of a pulmonary lobe was performed in one case. One patient was treated with rituximab alone. All the patients received HAART from 0 to 30 months after lymphoma diagnosis. Five patients achieved a CR after the first-line treatment. Subsequent transformation into DLBCL occured in the lung of one patient. To date, 7 patients are alive, from 12 to 111 months after diagnosis, including 5 patients in CR and 2 with stable disease. One patient in CR died at 66 months, with cerebrovascular accident. Conclusions. In HIV-infected patients, MALT lymphoma seems to have an indolent clinical course similar to MALT lymphomas occuring in immunocompetent patients. Table 1. 12 th Congress of the European Hematology Association haematologica/the hematology journal | 2007; 92(s1) | 269
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haematologica the hematology journa
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Information for readers, authors an
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EHA Executive Board E. Hellström-L
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Poster session I POSTER SESSION POS
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12 th Congress of the European Hema
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dasatinib. Methods. We studied Ikar
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Expression of the oncogene H-Ras an
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is the gene for the erythropoietin
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safety of a slow-release liposomal
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0029 OUTCOME OF THE TREATMENT OF AD
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drug-induced apoptotic response of
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41% in the PI3K- group (p=0.001). I
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Acute myeloid leukemia - Clinical I
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to 60 years (n=116, or 72%) receive
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0056 PROGNOSTIC SIGNIFICANCE OF FLT
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Anemia and Bone marrow failure 0061
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tified with the current protocol. S
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new cases of lead poisoning due to
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icance, from baseline to week 6 (p
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0086 THROMBELASTOGRAPHIC CHART RELI
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trials. The aim of this retrospecti
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tant function in this disease, nega
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ed to a favorable outcome. Bialleli
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stronger levels of p21 in the cell
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hematological centers in one countr
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ure 1). Conclusions. Results for re
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patients. After a median follow-up
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Cytogenetics and Molecular diagnost
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0135 ROUTINE DETECTION OF CYTOGENET
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(MMolR, defined as a BCR-ABL x 100
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0146 ARSENIC TRIOXIDE INDUCES ACCUM
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tinguish between genotypic B-cell l
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Genomics and proteomics 0158 PLASMA
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0164 EVALUATION OF MULTIPLEX LIGATI
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each patient’s replicate conditio
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0174 RELATION BETWEEN LOW PML-RARα
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0179 ESHAP VS GIN AS SALVAGE AND MO
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Immunology and gene therapy 0184 EA
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Cell viability was not affected by
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month is not relevant to chronic Gv
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Infection and supportive care I 020
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0206 POTENTIAL ROLE OF CMV IN THE O
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3H-thymidine uptake in cell culture
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0217 TUBERCULOSIS AMONG A COHORT OF
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0222 COMPARISON OF IWG 2006 AND IWG
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tem (IPSS) to h-MDS was also invest
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PCH97-19) were studied. Conventiona
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of erythroid colonies was reduced i
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0245 POTENT AND SELECTIVE INHIBITIO
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0250 INACTIVATION OF SUPPRESSOR OF
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Bortezomib 1.3 mg/m 2 days 1,4,8,11
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Response was defined according to E
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G-CSF can be used in neutropenic pa
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ence and functional activity of CD8
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itating tumor development, or engag
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phoma and SNT-13, -15 were establis
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usage (2/20 ie 10%) were observed.
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0294 MYCOSIS FUNGOIDES. IMMUNOHYSTO
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(range, 1-6) and 11 treatment cycle
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0306 RISK-ADAPTED IMMUNOCHEMOTHERAP
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functional activity was confirmed b
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No major toxicity, neither hematolo
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enewal potential of X-RAR-positive
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(50-99) respectively. Serial analys
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cell-interaction, adhesion and acti
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0340 ALTERED FIBRIN CLOT STRUCTURE
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Conclusions. This study demonstrate
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0354 FACTOR V LEIDEN HOMOZYGOUS GEN
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Results. From July 2005 through Mar
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0364 CLINICAL EFFICACY OF OXALIPLAT
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one marrow and peripheral blood ste
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ecently suggested (Boissel et al.,
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0378 SAFETY AND EFFICACY OF THE TER
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Cytogenetics and molecular diagnost
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0385 CYTOPLASMIC MUTATED NUCLEOPHOS
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0390 ELTROMBOPAG RAISES PLATELET CO
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factor for the achievement of CR wa
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The cases of RAS showed two peaks o
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is 85%. Seven out of the 25 relapse
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0409 FRACTIONATED RADIOIMMUNOTHERAP
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0414 COMPARATIVE ANALYSIS OF THE CO
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successfully managed with GM-CSF di
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49% for PCR positive patients (95%
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+8 (1 PR+1 HI) and 14/24 pts with c
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(e.g. bcr-abl leading to CML). CSC
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0438 TERC MUTATIONS ANALYSIS IN PAT
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observed in all mice. Analysis of l
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ex-vivo expansion of HUCB-derived H
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ic kidney disease in univariate or
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One hundred eleven CN AML patients,
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to asses intestinal epithelial dama
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genesis of acute myeloid leukaemia
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polymorphism at nucleotide 4889 of
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expression along with a decreased C
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0487 MUTATIONAL STATUS OF NUCLEOPHO
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previously reported, a single cours
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0497 SINGLE AGENT CLORETAZINE (VNP4
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ly received melphalan-based chemoth
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were similar among the 3 groups. Ho
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Methods. Several read-out systems w
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0518 SERUM AND CELLULAR EXPRESSION
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0523 DNA REPAIR INHIBITION IN RESTO
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held true when BMI-1 expression was
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Ph + cells in the bone marrow). We
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derivative chromosome (4p16, 7p14,
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0545 STABILIZED BONE MARROW IS NOT
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obtained in low (Sokal) risk patien
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median dose intensity being 800 (21
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from pivotal clinical trials. Metho
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Cytogenetics and Molecular diagnost
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to set up and optimize a D-HPLC-bas
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0576 WESTERN BLOT IDENTIFICATION OF
Page 225 and 226: Basic disease was AML (n=5), ALL (n
Page 227 and 228: 0588 EXTRACORPOREAL PHOTOPHORESIS F
Page 229 and 230: acquire a cytolytic capacity agains
Page 231 and 232: informed vignettes describing healt
Page 233 and 234: using CHOP-21 in the UK, pegfilgras
Page 235 and 236: 0609 SOFT TISSUE COMPLICATIONS IN P
Page 237 and 238: inding lectin (MBL) gene by polymer
Page 239 and 240: all infection rate (p=0.12) as well
Page 241 and 242: Myelodysplastic syndromes II 0623 M
Page 243 and 244: formation (in total 28 samples). Ti
Page 245 and 246: sion. In addition, confocal analysi
Page 247 and 248: Myeloproliferative disorders - Clin
Page 249 and 250: open-label, multi-centre study enro
Page 251 and 252: iopsies after 6 and 12 months treat
Page 253 and 254: Myeloproliferative disorders Chroni
Page 255 and 256: ash, muscolar cramps, diarrhoea, he
Page 257 and 258: induced significant apoptosis (mean
Page 259 and 260: Myeloma and other monoclonal gammop
Page 261 and 262: the therapy of choice for POEMS is
Page 263 and 264: er patient does not indicate such t
Page 265 and 266: Myeloma and other monoclonal gammop
Page 267 and 268: secutive patients with MM, referred
Page 269 and 270: whether gene expression values may
Page 271 and 272: 0705 THE SHIFT OF TREATMENT FOR NAS
Page 273 and 274: 0710 CLINICO-PATHOLOGICAL FEATURES,
Page 275: patients presented a stage IV disea
Page 279 and 280: known at NHL diagnosis, were includ
Page 281 and 282: 0731 THE IMPACT OF HIV ON NON-HODGK
Page 283 and 284: patients had died of their underlyi
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Page 287 and 288: modulated after 24 h (37 up- and 59
Page 289 and 290: 0753 A SUSTAINED REMISSION OF IDIOP
Page 291 and 292: and treatment, has rarely been syst
Page 293 and 294: uncontrolled massive bleeding affec
Page 295 and 296: Results. A total of 396 patients we
Page 297 and 298: C30 questionnaire, and the correspo
Page 299 and 300: wave length of light of reflected r
Page 301 and 302: 0783 PREVALENCE OF MEMBRANE PROTEIN
Page 303 and 304: erozygous mother has a more severe
Page 305 and 306: 0794 CARDIAC MANIFESTATIONS IN A BR
Page 307 and 308: 0799 INEFFECTIVE ERYTHROPOIESIS IN
Page 309 and 310: p=0.014 and p=0.003, respectively).
Page 311 and 312: 0809 CURRENT APPROACH TO CHELATION
Page 313 and 314: Thrombosis II 0814 UNSUSPECTED PULM
Page 315 and 316: the 97.5th percentile (5.2 U/mL) ge
Page 317 and 318: symptoms of DVT, 3 (7.89%) previous
Page 319 and 320: Transfusion medicine and vascular b
Page 321 and 322: tions (most bacterial, 2 malaria, 6
Page 323 and 324: 0844 INCREASED LEUKOCYTE-PLATELET I
Page 325 and 326: 0851 CORD BLOOD DERIVED MESENCHYMAL
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SIMULTANEOUS SESSION II Chronic mye
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0862 COMPARISON OF DASATINIB TO HIG
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0867 COMPREHENSIVE GERIATRIC ASSESS
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0872 MN1 INDUCES LEUKEMIA IN MICE A
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0877 PAX5/TEL TRANSDUCED PRE-BI CEL
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0882 CISPLATIN INDUCES THROMBIN GEN
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have an early manifestation of typi
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0892 INTEGRATION OF GENOME WIDE SNP
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0897 THE PHENOTYPE OF JAK2V617F MUT
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gest diverse sequences of NPM mutan
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2004 to January, 2006. At enrollmen
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with a p value of ≥ 0.10. Sets of
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BRIC 126 and 4N1K) in cells lacking
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sclerosis[NS] and 12 Mixed cellular
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0927 MK-0457, A NOVEL MULTIKINASE I
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Publication Only 0933 CLINICAL FEAT
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HSCT from the available Asian as we
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that the incidence of JAK2 mutation
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without type 2 diabetes. Methods. T
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pts (38.8%) that were isolated (abs
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y using the Miltenyi CD34 isolation
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0969 COMPARISON OF CD25 IMMUNOHISTO
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cytes was 24 days (range 8-32 days)
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a cytogenetic hallmark for M4/M5 su
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normal human BM B progenitor cells
Page 377 and 378:
0994 INCIDENCE OF INVASIVE ASPERGIL
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3 of disease relapse.TRM at day+100
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survival of five years. This dismal
Page 383 and 384:
1011 FLOW CYTOMETRIC DNA INDEX AND
Page 385 and 386:
1018 THE EFFECT OF THE SUGARBAKER P
Page 387 and 388:
1024 KIR/HLA CLASS I MISMATCHING AN
Page 389 and 390:
ment details and thrombotic histori
Page 391 and 392:
1036 INCIDENCE AND SPECTRUM OF INFE
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tinely by our stem cell lab prior t
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tion to a translocation t(5;14)(q35
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ment of CML and induces a high rate
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due to reactivation and/or progress
Page 401 and 402:
1063 ABNORMAL METHYLATION STATUS OF
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1069 CLINICAL RELEVANCE OF REGULATO
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1076 SERUM LEVELS OF SOLUBLE HLA CL
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patient is still undergoing intensi
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nificant MVD differences were detec
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dictor of OS (p=0.004). High dose t
Page 413 and 414:
1099 ALTERATIONS IN THE NATURAL KIL
Page 415 and 416:
1105 CYTOGENETIC ABNORMALITIES IN 3
Page 417 and 418:
1110 CONSTITUTIVE ACTIVATION OF STA
Page 419 and 420:
efficacy results with a well-tolera
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unmutated VH genes, and high and lo
Page 423 and 424:
Aims. Aim of this study was to pred
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tested across a wide range of human
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were incidentally diagnosed (52%).
Page 429 and 430:
ß2GP1 may be considered as determi
Page 431 and 432:
characterized in 198 β thalassaemi
Page 433 and 434:
1155 PLATELET AGGREGATION IN CHILDR
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to-pelvic or perineal trauma. No me
Page 437 and 438:
in age. High prevalence of LBM amon
Page 439 and 440:
ecause some of the patients were or
Page 441 and 442:
of the drug is crucial to allow lon
Page 443 and 444:
egarding cost analysis of ASCT in G
Page 445 and 446:
ID Allo-BMT, 1 family one mismatche
Page 447 and 448:
admitted to ICU were discharged des
Page 449 and 450:
events -Postoperative states: 9,19%
Page 451 and 452:
efficacy and decreased atherosclero
Page 453 and 454:
1217 INCIDENCE OF EARLY STAGE IDIOP
Page 455 and 456:
1691GA and 1 homozygous 1691AA. The
Page 457 and 458:
1230 ASSOCIATION OF HEPARANASE GENE
Page 459 and 460:
posed, was: DF = (CD43%+FMC7%+CD79b
Page 461 and 462:
treatment of acute promyelocityc le
Page 463 and 464:
loaded group and 35 (70%) were non-
Page 465 and 466:
mild. Fas and soluble Fas ligand le
Page 467 and 468:
1265 POSACONAZOLE THERAPY IN REFRAC
Page 469 and 470:
ly express the cytoplasmic (inactiv
Page 471 and 472:
findings confirmed the significant
Page 473 and 474:
a less favorable prognosis. Interes
Page 475 and 476:
disease (HD), 4 patients (9%) with
Page 477 and 478:
1295 HEMOPHAGOCYTIC LYMPHOHYSTIOCYT
Page 479 and 480:
phamide 750 mg/m 2 on day 1, vincri
Page 481 and 482:
nomenon is unclear. It has been sug
Page 483 and 484:
oped mild thrombocytopenia (platele
Page 485 and 486:
gle dose of 54mg/m 2 rituximab furt
Page 487 and 488:
patients (pts), 36 male, with acute
Page 489 and 490:
esulting alterations of the endothe
Page 491 and 492:
(range 1-7) and 28,6% of patients h
Page 493 and 494:
three decades. In vivo, Ara-C is tr
Page 495 and 496:
statistical analysis. Results. Seve
Page 497 and 498:
Results. Though there was no recogn
Page 499 and 500:
2% and 19% of patients with or with
Page 501 and 502:
were older than 65 y) which can be
Page 503 and 504:
1376 RESVERATROL INDUCED P53 MEDIAT
Page 505 and 506:
median time of 21 days to reach >0.
Page 507 and 508:
ly. Conclusions. 1. Combined intens
Page 509 and 510:
to the presence of IVS1-6 mutation
Page 511 and 512:
fy predictive factors for these abn
Page 513 and 514:
acute leukemia. However, we cannot
Page 515 and 516:
agents. They involve primarily the
Page 517 and 518:
voriconazole for 2 months followed
Page 519 and 520:
typed using a commercially availabl
Page 521 and 522:
low up of ABL KD mutations’ level
Page 523 and 524:
with development of BC/AP. 2. EVI-1
Page 525 and 526:
1447 THE IMPACT OF DISPARITY IN SHO
Page 527 and 528:
three had visual field defects, two
Page 529 and 530:
acquired mutation most prone to cau
Page 531 and 532:
1466 ROS GENERATION AND APOPTOSIS I
Page 533 and 534:
1473 DIARRHEIC SYNDROME, A CLINICAL
Page 535 and 536:
gene fusion is an independent progn
Page 537 and 538:
1484 EPIDEMIOLOGY AND RESPONSE TO T
Page 539 and 540:
1492 FREQUENCY OF MEDITERRANEAN GLU
Page 541 and 542:
immune globulin was administered at
Page 543 and 544:
maintained on Imatinib 400 mg. Afte
Page 545 and 546:
Hodgkin’s disease is well known,
Page 547 and 548:
gram provided a unique chance to de
Page 549 and 550:
even when ADP-induced plt activatio
Page 551 and 552:
medullary involvement of multiple m
Page 553 and 554:
1540 ADMINISTRATION OF G-CSF AND CH
Page 555 and 556:
1548 QUALITY ANALYSIS OF THE MULTID
Page 557 and 558:
Index of authors A Aapro, M., 0377,
Page 559 and 560:
Bahr, J., 0148 Bai, M., 1551 Baia,
Page 561 and 562:
Bottini, P.V., 1181 Botto, B., 0408
Page 563 and 564:
Chaidos, A., 0456, 0498, 0599, 0686
Page 565 and 566:
De Keersmaecker, K., 0442, 0875 De
Page 567 and 568:
El-Sharkawy, N., 0016 Elwahidi, G.,
Page 569 and 570:
Garcia-Frade, J., 0346, 0680, 1105
Page 571 and 572:
H Haas, N., 0742 Haas, O.A., 0001,
Page 573 and 574:
Jaksic, B., 0127, 0446 Jaksic, O.,
Page 575 and 576:
Körmöczi, G., 0848 Kornblau, S.,
Page 577 and 578:
Lin, L.-I., 0030, 0484 Lin, T., 012
Page 579 and 580:
Massé, A., 0249 Massó, P., 1287,
Page 581 and 582:
Musto, P., 0254, 0401, 0422, 0569,
Page 583 and 584:
Papadavid, E., 1442 Papageorgiou, E
Page 585 and 586:
Probatova, N., 0704 Prochazka, V.,
Page 587 and 588:
Rykavicin, O., 0504 Ryningen, A., 0
Page 589 and 590:
Sirard, C., 0127, 0128 Sirigou, A.,
Page 591 and 592:
Thiebaut, A., 0454 Thieblemont, C.,
Page 593 and 594:
Vincenzi, C., 1060 Viniou, N.-A., 0
Page 595 and 596:
Zouabi, H., 0503, 0999 Zoumbos, N.C
Page 597 and 598:
Page 599 and 600:
Page 601 and 602:
Page 603:
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