12th Congress of the European Hematology ... - Haematologica

12 th Congress of the European Hematology Association
that the total population of Malabo is of 90,000 inhabitants hope that 1
of each 7 is carrying of HbS (~13.000 carrying), as soon as the HbS/HbS
would be 2,610 individuals (1/34) and approximately 6,000 with some
variant of structural hemoglobinopathie (1/15). In spite of the means
shortage and rudimentary of the collection of the samples only 16.8%
of the total they could not be analyzed. For that reason and by the high
incidence of the HbS it would be precise that policies of cooperation for
the diagnosis, treatment and prevention of the homocigous forms settled
down, as well as to collaborate in the formation of the sanitary personnel
to give the suitable genetic advice.
1392
SERUM HEPCIDIN LEVELS IN CHILDREN WITH SOLID TUMORS, INFLAMATORY BOWEL
DISEASE AND IRON DEFICIENCY ANEMIA
T. Gursel, E. Yildiz, Z. Kaya, U. Kocak, M. Albayrak
Gazi University,School of Medicine, ANKARA, Turkey
Background. Hepcidin is an hepatic peptide that regulates iron homeostasis
by inhibiting iron absorption in enterocytes, the efflux of iron
from macrophages and the release of iron from hepatocytes. Its synthesis
is induced by inflammatory stimuli and iron overload, and inhibited
by anemia and hypoxia. It has been suggested that hepcidin may be
responsible for anemia in inflamatory diseases. The aims of this study
were to determine the hepcidin level in anemia of chronic diseases and
iron deficiency anemia in children, and to evaluate its correlations with
inflammatory markers and iron parameters. Methods. The levels of serum
hepcidin, high-sensitivity CRP, ferritin, serum iron, transferrin saturation
and soluble transferrin receptor were measured by commercially available
kits, and complete blood count and erythrocyte sedimentation rate
by conventional methods in children with solid tumors (ST, n:16),
inflammatory bowel disease (IBD, n:15), iron deficiency anemia (IDA,
n: 15) and age matched healthy controls (n:15). The study was approved
by our IRB. Results. The mean value of serum hepcidin was significantly
higher (p< 0.01) in children with ST (661.5±217.2 ng/dL) (± SD) and
IBD (775.7±395.8 ng/dL) than in age matched healthy controls
(426.1±208.9 ng/dL ) but not significantly different between ST and IBD.
The mean value of hepcidin in children with IDA (303.5±81.5 ng/dL)
was not significantly different from that in controls. Serum hepcidin
showed positive correlation with serum ferritin in ST (r:0.77, p:0.01)
and IBD (r: 0.58, p:0.02), and with transferrin saturation in IDA (r:0.59,
p0.05)
respectively. The prevalence of Hp infection was 38% in CITP patients
and 46% in the control group (p>0.05). The risk factors for acquiring Hp
infection in CITP patients (positive vs negative) were male sex (62% vs
26.5%; p