12th Congress of the European Hematology ... - Haematologica

12 th Congress of the European Hematology Association
status, monoclonal immunoglobulins (MG) and plasmacytic differentiation
(PD). All patients with follow-up at our institution were analysed,
and influence of various parameters on dissemination and outcome were
evaluated. Sixty-five patients (38%) had gastric MALT-lymphoma (GML)
and 108 (62%) extragastric MALT-lymphoma (EGML). Results. 68/172
patients (39%) had multiorgan-involvement upon presentation, while
only 3 patients had bone marrow involvement. Patients with EGML
(51/108, 47%) were at significantly higher risk for multiorgan-disease
than patients with GML (17/65, 27%, p=0.013). 58 patients had genetic
aberrations, with t(11;18) being more common in GML (p=0.002) and trisomy
3 (p=0.03) and trisomy 18 (p=0.02) in EGML. Among GML, translocation
t(11;18) was significantly associated with multiorgan-disease, as
was trisomy18 in EGML (p=0.038). After a median follow-up time of 42
months, 142 patients (86%) are alive.58 patients (39%) have relapsed,
with the median to relapse being 60 months. Overall, multifocality and
extragastric origin (p