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12 th Congress of the European Hematology Association patient SCT team include a general physician, staff nurse and care giver during their neutropenic period. All data collected and analyzed by SPSS software. Results. 60 patients received in-patient or out-patient autologus SCT. In the in-patient group20, 20 patients received 200 mg/m 2 and 140 mg/m 2 melphalan respectively as conditioning regimens. In out-patient group 20 patients received 140mg/m 2 melphalan. Median ages were 50±7.5 and patients were in complete (85%) or partial (15%) remission. Median hospital stay were 28 days (19-54) and 6.5 days (1-8) in in-patient and out-patient groups respectively. Median home visit by team were 10.5 days. There were not significant difference (p
that the incidence of JAK2 mutation in Asian ET patients is lower than in Caucasian ET patients. Their disease profile may be similar to that of their wild-type counterparts and different from the Caucasian patients. 0947 THE PREPARATION OF MONOCLONAL IMMUNOGLOBULIN LOADED DENDRITIC CELLS VACCINE FOR MYELOMA PATIENTS UNDER GMP CONDITIONS: PRECLINICAL AND FIRST CLINICAL RESULTS OF A PHASE I/II CLINICAL TRIAL D. Ocadlikova, 1 L. Zahradova, 2 L. Kovarova, 1 J. Smejkalova, 1 L. Pour, 2 P. Vidlakova, 1 D. Kyjovska, 1 A. Stejskalova, 1 H. Novotna, 3 M. Penka, 4 J. Michalek, 1 R. Hajek2 1 2 Cell Immunotherapy Center, BRNO; Department of Hematooncology, BRNO; 3 4 Department of Clinical Biochemistry, BRNO; Department of Clinical Hematology, BRNO, Czech Republic Background: Adjuvant immunotherapy with antigen-loaded dendritic cells (DCs) represents a novel and relatively non-toxic treatment modality for multiple myeloma (MM). Malignant cells in MM produce a monoclonal immunoglobulin (idiotypic protein) which is considered a tumorspecific antigen and can be used for the induction of T lymphocytes. To enhance the anti-myeloma immune response, the idiotypic protein (Idprotein; Idiotype) can be loaded into autologous DCs and used for vaccination. Aims. The aim of this study was preclinical evaluation of to evaluate DC-based vaccine and clinical demonstration of the safety and immune response of the vaccine in patients with MM. Patients and Methods. Pre-clinical testing was performed in 8 patients with MM. DC loaded with autologous myeloma cells were used for autologous T cell stimulation in vitro. After successful preclinical testing, we have vaccinated 4 patients with stable disease or asymptomatic slow progressive disease after prior stem cell transplant (SCT) according to EBMT criteria. DC precursors were isolated as an adherent fraction from peripheral blood of the myeloma patients. DCs were prepared in vitro and loaded with Idprotein under GMP conditions as previously described (Ocadlikova et al. Med Oncol 2006, 23: 377-384). Patients were vaccinated every 4 weeks subcutaneously with 6 doses, each containing 1,46-18,1×10 6 (mean 9,52×10 6 ) DCs. The immune response was evaluated by flow cytometry, Elispot and the skin test of hypersensitivity. Results. IFN-gamma production of T cells stimulated with autologous myeloma cell loaded DC was observed. After successful pre-clinical testing a clinical phase I/II trial was initiated. A total of 24 vaccines were applied to 4 patients so far (January 2007). The viability, number and functional characteristics of in vitro matured DCs loaded with Id-protein were satisfactory with 50,10-99,3% (mean 87,08%) of HLADR/CD86+ cells. Each vaccination was well tolerated with only mild fever in 1 patient. No grade II-IV toxicity appeared. The clinical trial is ongoing and a total of 12 patients is planned to be enrolled. Conclusions. Feasibility and safety of vaccination with Id-protein loaded autologous dendritic cells was proved in patients with multiple myeloma. Supported by IGA MZCR NR 8945-4. 0948 ISOLATION AND EXPANSION OF ALLOGENEIC MYELOMA-SPECIFIC T CELLS PRODUCING INTERFERON-GAMMA D. Ocadlikova, 1 L. Zahradova, 2 L. Kovarova, 1 A. Stejskalova, 1 M. Penka, 3 R. Hajek, 2 J. Michalek1 1 Cell Immunotherapy Center, BRNO; 2 Department of Hematooncology, BRNO; 3 Department of Clinical Hematology, BRNO, Czech Republic Background. Multiple myeloma (MM) is a malignant disease characterized by clonal proliferation of plasma cells in the bone marrow. Highdose chemotherapy with autologous stem cell transplantation is recently considered a standard therapy for myeloma. Despite of the high number of complete remissions achievement is the median relapse-free survival 3 years and median overall survival of 4 to 5 years. Adoptive immunotherapy is a promising approach in the treatment of multiple myeloma in the last 20 years. Aims. The aim of this study was to identify and characterize autologous myeloma-reactive T cells in vitro and to evaluate their cytotoxic effect. Methods. Irradiated myeloma cell line ARH 77 has been used as tumor antigen to stimulate allogeneic CD4 + and CD8+ T lymphocytes. Peripheral blood mononuclear cells of 8 healthy volunteers and 10 MM patients were used for repeated stimulation of T lymphocytes. Activated myeloma-specific T cells that produced interferon-gamma (IFN-γ) were isolated using immunomagnetic separation (Miltenyi Biotech) and further expanded in vitro by phytohemaglutinin and high concentrations of interleukin 2. Cytotoxicity against the original myeloma cells has been tested after the T cell expansion with propidi- 12 th Congress of the European Hematology Association um iodide or 7-amino actinomycin D. Activated T cells were labeled by a 5-(6-) carboxyfluoresceine diacetate succinimidyl ester. Allogeneic T cells and IFN-γ negative fraction of T cells served as controls. Results. Myeloma-reactive IFN-γ positive T cells in healthy donors were enriched from 2.83% (1.97%; 4.58%) to 48.57% (15.14%; 82.98%) and from 1.91% (1.14%; 3.4%) to 73.14% (3.9%; 88.75%) (median, min., max.) for CD3 + CD4 + and CD3 + CD8 + T cells after immunomagnetic separation. IFN-γ positive T cells were further expanded in vitro from 0.5×10 6 (0.5×10 6 ; 0.6×10 6 ) to 160×10 6 (150×10 6 , 420×10 6 ) (median, min., max.) cells within 4 weeks. The percentage of killed ARH 77 myeloma cells was 69.17% (38.04%; 78.23%) (median, min., max.). Cytotoxicity against the third-party PBMC was negligible. IFN-γ negative fraction of T cells demonstrated also negligible cytotoxicity against ARH 77 myeloma cells. The percentage of myeloma-reactive IFN-γ positive cells in MM patients was enriched from 1.12% (0.27%; 6.2%) to 7.85% (0.42%; 12.6%) and from 1.9% (0.37%; 14.4%) to 14.7% (1.28%; 71.4%) (median, min., max.) for CD3 + CD4 + and CD3 + CD8 + T cells after immunomagnetic separation. IFN-γ positive T cells were expanded in vitro from 0.12 ×10 6 (0.05 ×10 6 ; 0.4 ×10 6 ) to 88.5 ×10 6 (35 ×10 6 ; 226 ×10 6 ) (median, min., max.) within 8-12 weeks. The percentage of killed autologous multiple myeloma cells was 41,5% (15,6-60,5%) (median, min., max.). For the 2:1, 10:1 and 50:1 E:T ratios, the median killing of ARH 77 myeloma cells was 21.78%, 34.31% and 62.33% after 4 hours; 60.84%, 69.82%, and 73.49% after 24, and 57.75%, 71.85% and 59.69% after 48 hours, respectively. Third-party reactivity of myeloma-reactive T cells from patients with MM was negligible. Conclusion: This study demonstrates the feasibility of identification and isolation of myeloma-specific T cells in healthy donors as well as in patients with MM. Myeloma-specific T cells can be further expanded and used as adoptive immunotherapy. Supported by IGA MZCR NR 8945-4. 0949 ASSOCIATION OF ZAP-70 EXPRESSION WITH PLASMA LEVELS OF ANGIOGENIC ACTIVATORS IN CHRONIC LYMPHOCYTIC LEUKEMIA L. Smolej, C. Andrys, V. Vroblova, J. Novosad, D. Belada, P. Zak, J. Krejsek, M. Hrudkova, O. Siroky, J. Maly University Hospital and Medical School, HRADEC KRALOVE, Czech Republic Background. Chronic lymphocytic leukaemia (CLL) is a disease with an extremely variable clinical course. Several studies have shown that angiogenesis is increased in CLL and may potentially serve as a new prognostic factor. Zeta-associated protein of 70 kilodaltons (ZAP-70) is an intracellular tyrosin kinase belonging to modern powerful prognostic markers in CLL with significant impact on clinical course. Aims. to assess potential relationship of ZAP-70 and angiogenic signaling in CLL. Methods. We analyzed ZAP-70 expression using flow cytometry in CLL cells from peripheral blood of 32 patients. Furthemore, we quantified plasma concentrations of angiogenic activators (vascular endothelial growth factor - VEGF, basic fibroblast growth factor - bFGF) in peripheral blood plasma of the same CLL patient group and 80 healthy donors. Commercially available sandwich ELISA kits (RD Systems) were used for bFGF and VEGF measurement. ZAP-70 expression was quantified using PEconjugated ZAP-70 monoclonal antibody (Caltag); cut-off level of 20% positivity was used as recommended by literature. Results. Both angiogenic cytokines were significantly increased in CLL patients when compared to controls (bFGF, p
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haematologica the hematology journa
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Information for readers, authors an
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EHA Executive Board E. Hellström-L
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Poster session I POSTER SESSION POS
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12 th Congress of the European Hema
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dasatinib. Methods. We studied Ikar
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Expression of the oncogene H-Ras an
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is the gene for the erythropoietin
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safety of a slow-release liposomal
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0029 OUTCOME OF THE TREATMENT OF AD
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drug-induced apoptotic response of
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41% in the PI3K- group (p=0.001). I
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Acute myeloid leukemia - Clinical I
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to 60 years (n=116, or 72%) receive
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0056 PROGNOSTIC SIGNIFICANCE OF FLT
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Anemia and Bone marrow failure 0061
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tified with the current protocol. S
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new cases of lead poisoning due to
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icance, from baseline to week 6 (p
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0086 THROMBELASTOGRAPHIC CHART RELI
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trials. The aim of this retrospecti
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tant function in this disease, nega
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ed to a favorable outcome. Bialleli
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stronger levels of p21 in the cell
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hematological centers in one countr
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ure 1). Conclusions. Results for re
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patients. After a median follow-up
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Cytogenetics and Molecular diagnost
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0135 ROUTINE DETECTION OF CYTOGENET
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(MMolR, defined as a BCR-ABL x 100
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0146 ARSENIC TRIOXIDE INDUCES ACCUM
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tinguish between genotypic B-cell l
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Genomics and proteomics 0158 PLASMA
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0164 EVALUATION OF MULTIPLEX LIGATI
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each patient’s replicate conditio
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0174 RELATION BETWEEN LOW PML-RARα
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0179 ESHAP VS GIN AS SALVAGE AND MO
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Immunology and gene therapy 0184 EA
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Cell viability was not affected by
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month is not relevant to chronic Gv
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Infection and supportive care I 020
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0206 POTENTIAL ROLE OF CMV IN THE O
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3H-thymidine uptake in cell culture
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0217 TUBERCULOSIS AMONG A COHORT OF
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0222 COMPARISON OF IWG 2006 AND IWG
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tem (IPSS) to h-MDS was also invest
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PCH97-19) were studied. Conventiona
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of erythroid colonies was reduced i
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0245 POTENT AND SELECTIVE INHIBITIO
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0250 INACTIVATION OF SUPPRESSOR OF
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Bortezomib 1.3 mg/m 2 days 1,4,8,11
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Response was defined according to E
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G-CSF can be used in neutropenic pa
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ence and functional activity of CD8
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itating tumor development, or engag
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phoma and SNT-13, -15 were establis
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usage (2/20 ie 10%) were observed.
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0294 MYCOSIS FUNGOIDES. IMMUNOHYSTO
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(range, 1-6) and 11 treatment cycle
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0306 RISK-ADAPTED IMMUNOCHEMOTHERAP
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functional activity was confirmed b
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No major toxicity, neither hematolo
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enewal potential of X-RAR-positive
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(50-99) respectively. Serial analys
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cell-interaction, adhesion and acti
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0340 ALTERED FIBRIN CLOT STRUCTURE
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Conclusions. This study demonstrate
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0354 FACTOR V LEIDEN HOMOZYGOUS GEN
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Results. From July 2005 through Mar
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0364 CLINICAL EFFICACY OF OXALIPLAT
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one marrow and peripheral blood ste
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ecently suggested (Boissel et al.,
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0378 SAFETY AND EFFICACY OF THE TER
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Cytogenetics and molecular diagnost
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0385 CYTOPLASMIC MUTATED NUCLEOPHOS
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0390 ELTROMBOPAG RAISES PLATELET CO
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factor for the achievement of CR wa
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The cases of RAS showed two peaks o
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is 85%. Seven out of the 25 relapse
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0409 FRACTIONATED RADIOIMMUNOTHERAP
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0414 COMPARATIVE ANALYSIS OF THE CO
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successfully managed with GM-CSF di
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49% for PCR positive patients (95%
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+8 (1 PR+1 HI) and 14/24 pts with c
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(e.g. bcr-abl leading to CML). CSC
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0438 TERC MUTATIONS ANALYSIS IN PAT
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observed in all mice. Analysis of l
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ex-vivo expansion of HUCB-derived H
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ic kidney disease in univariate or
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One hundred eleven CN AML patients,
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to asses intestinal epithelial dama
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genesis of acute myeloid leukaemia
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polymorphism at nucleotide 4889 of
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expression along with a decreased C
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0487 MUTATIONAL STATUS OF NUCLEOPHO
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previously reported, a single cours
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0497 SINGLE AGENT CLORETAZINE (VNP4
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ly received melphalan-based chemoth
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were similar among the 3 groups. Ho
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Methods. Several read-out systems w
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0518 SERUM AND CELLULAR EXPRESSION
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0523 DNA REPAIR INHIBITION IN RESTO
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held true when BMI-1 expression was
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Ph + cells in the bone marrow). We
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derivative chromosome (4p16, 7p14,
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0545 STABILIZED BONE MARROW IS NOT
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obtained in low (Sokal) risk patien
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median dose intensity being 800 (21
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from pivotal clinical trials. Metho
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Cytogenetics and Molecular diagnost
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to set up and optimize a D-HPLC-bas
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0576 WESTERN BLOT IDENTIFICATION OF
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Basic disease was AML (n=5), ALL (n
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0588 EXTRACORPOREAL PHOTOPHORESIS F
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acquire a cytolytic capacity agains
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informed vignettes describing healt
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using CHOP-21 in the UK, pegfilgras
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0609 SOFT TISSUE COMPLICATIONS IN P
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inding lectin (MBL) gene by polymer
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all infection rate (p=0.12) as well
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Myelodysplastic syndromes II 0623 M
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formation (in total 28 samples). Ti
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sion. In addition, confocal analysi
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Myeloproliferative disorders - Clin
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open-label, multi-centre study enro
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iopsies after 6 and 12 months treat
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Myeloproliferative disorders Chroni
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ash, muscolar cramps, diarrhoea, he
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induced significant apoptosis (mean
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Myeloma and other monoclonal gammop
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the therapy of choice for POEMS is
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er patient does not indicate such t
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Myeloma and other monoclonal gammop
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secutive patients with MM, referred
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whether gene expression values may
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0705 THE SHIFT OF TREATMENT FOR NAS
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0710 CLINICO-PATHOLOGICAL FEATURES,
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patients presented a stage IV disea
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plete remission or recurrent diseas
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known at NHL diagnosis, were includ
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0731 THE IMPACT OF HIV ON NON-HODGK
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patients had died of their underlyi
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scripts and proteins most affected
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modulated after 24 h (37 up- and 59
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0753 A SUSTAINED REMISSION OF IDIOP
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and treatment, has rarely been syst
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uncontrolled massive bleeding affec
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Results. A total of 396 patients we
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C30 questionnaire, and the correspo
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wave length of light of reflected r
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0783 PREVALENCE OF MEMBRANE PROTEIN
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erozygous mother has a more severe
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0794 CARDIAC MANIFESTATIONS IN A BR
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0799 INEFFECTIVE ERYTHROPOIESIS IN
Page 309 and 310: p=0.014 and p=0.003, respectively).
Page 311 and 312: 0809 CURRENT APPROACH TO CHELATION
Page 313 and 314: Thrombosis II 0814 UNSUSPECTED PULM
Page 315 and 316: the 97.5th percentile (5.2 U/mL) ge
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Page 319 and 320: Transfusion medicine and vascular b
Page 321 and 322: tions (most bacterial, 2 malaria, 6
Page 323 and 324: 0844 INCREASED LEUKOCYTE-PLATELET I
Page 325 and 326: 0851 CORD BLOOD DERIVED MESENCHYMAL
Page 327 and 328: SIMULTANEOUS SESSION II Chronic mye
Page 329 and 330: 0862 COMPARISON OF DASATINIB TO HIG
Page 331 and 332: 0867 COMPREHENSIVE GERIATRIC ASSESS
Page 333 and 334: 0872 MN1 INDUCES LEUKEMIA IN MICE A
Page 335 and 336: 0877 PAX5/TEL TRANSDUCED PRE-BI CEL
Page 337 and 338: 0882 CISPLATIN INDUCES THROMBIN GEN
Page 339 and 340: have an early manifestation of typi
Page 341 and 342: 0892 INTEGRATION OF GENOME WIDE SNP
Page 343 and 344: 0897 THE PHENOTYPE OF JAK2V617F MUT
Page 345 and 346: gest diverse sequences of NPM mutan
Page 347 and 348: 2004 to January, 2006. At enrollmen
Page 349 and 350: with a p value of ≥ 0.10. Sets of
Page 351 and 352: BRIC 126 and 4N1K) in cells lacking
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Page 355 and 356: 0927 MK-0457, A NOVEL MULTIKINASE I
Page 357 and 358: Publication Only 0933 CLINICAL FEAT
Page 359: HSCT from the available Asian as we
Page 363 and 364: without type 2 diabetes. Methods. T
Page 365 and 366: pts (38.8%) that were isolated (abs
Page 367 and 368: y using the Miltenyi CD34 isolation
Page 369 and 370: 0969 COMPARISON OF CD25 IMMUNOHISTO
Page 371 and 372: cytes was 24 days (range 8-32 days)
Page 373 and 374: a cytogenetic hallmark for M4/M5 su
Page 375 and 376: normal human BM B progenitor cells
Page 377 and 378: 0994 INCIDENCE OF INVASIVE ASPERGIL
Page 379 and 380: 3 of disease relapse.TRM at day+100
Page 381 and 382: survival of five years. This dismal
Page 383 and 384: 1011 FLOW CYTOMETRIC DNA INDEX AND
Page 385 and 386: 1018 THE EFFECT OF THE SUGARBAKER P
Page 387 and 388: 1024 KIR/HLA CLASS I MISMATCHING AN
Page 389 and 390: ment details and thrombotic histori
Page 391 and 392: 1036 INCIDENCE AND SPECTRUM OF INFE
Page 393 and 394: tinely by our stem cell lab prior t
Page 395 and 396: tion to a translocation t(5;14)(q35
Page 397 and 398: ment of CML and induces a high rate
Page 399 and 400: due to reactivation and/or progress
Page 401 and 402: 1063 ABNORMAL METHYLATION STATUS OF
Page 403 and 404: 1069 CLINICAL RELEVANCE OF REGULATO
Page 405 and 406: 1076 SERUM LEVELS OF SOLUBLE HLA CL
Page 407 and 408: patient is still undergoing intensi
Page 409 and 410: nificant MVD differences were detec
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dictor of OS (p=0.004). High dose t
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1099 ALTERATIONS IN THE NATURAL KIL
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1105 CYTOGENETIC ABNORMALITIES IN 3
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1110 CONSTITUTIVE ACTIVATION OF STA
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efficacy results with a well-tolera
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unmutated VH genes, and high and lo
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Aims. Aim of this study was to pred
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tested across a wide range of human
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were incidentally diagnosed (52%).
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ß2GP1 may be considered as determi
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characterized in 198 β thalassaemi
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1155 PLATELET AGGREGATION IN CHILDR
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to-pelvic or perineal trauma. No me
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in age. High prevalence of LBM amon
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ecause some of the patients were or
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of the drug is crucial to allow lon
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egarding cost analysis of ASCT in G
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ID Allo-BMT, 1 family one mismatche
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admitted to ICU were discharged des
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events -Postoperative states: 9,19%
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efficacy and decreased atherosclero
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1217 INCIDENCE OF EARLY STAGE IDIOP
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1691GA and 1 homozygous 1691AA. The
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1230 ASSOCIATION OF HEPARANASE GENE
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posed, was: DF = (CD43%+FMC7%+CD79b
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treatment of acute promyelocityc le
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loaded group and 35 (70%) were non-
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mild. Fas and soluble Fas ligand le
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1265 POSACONAZOLE THERAPY IN REFRAC
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ly express the cytoplasmic (inactiv
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findings confirmed the significant
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a less favorable prognosis. Interes
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disease (HD), 4 patients (9%) with
Page 477 and 478:
1295 HEMOPHAGOCYTIC LYMPHOHYSTIOCYT
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phamide 750 mg/m 2 on day 1, vincri
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nomenon is unclear. It has been sug
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oped mild thrombocytopenia (platele
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gle dose of 54mg/m 2 rituximab furt
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patients (pts), 36 male, with acute
Page 489 and 490:
esulting alterations of the endothe
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(range 1-7) and 28,6% of patients h
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three decades. In vivo, Ara-C is tr
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statistical analysis. Results. Seve
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Results. Though there was no recogn
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2% and 19% of patients with or with
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were older than 65 y) which can be
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1376 RESVERATROL INDUCED P53 MEDIAT
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median time of 21 days to reach >0.
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ly. Conclusions. 1. Combined intens
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to the presence of IVS1-6 mutation
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fy predictive factors for these abn
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acute leukemia. However, we cannot
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agents. They involve primarily the
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voriconazole for 2 months followed
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typed using a commercially availabl
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low up of ABL KD mutations’ level
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with development of BC/AP. 2. EVI-1
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1447 THE IMPACT OF DISPARITY IN SHO
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three had visual field defects, two
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acquired mutation most prone to cau
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1466 ROS GENERATION AND APOPTOSIS I
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1473 DIARRHEIC SYNDROME, A CLINICAL
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gene fusion is an independent progn
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1484 EPIDEMIOLOGY AND RESPONSE TO T
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1492 FREQUENCY OF MEDITERRANEAN GLU
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immune globulin was administered at
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maintained on Imatinib 400 mg. Afte
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Hodgkin’s disease is well known,
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gram provided a unique chance to de
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even when ADP-induced plt activatio
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medullary involvement of multiple m
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1540 ADMINISTRATION OF G-CSF AND CH
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1548 QUALITY ANALYSIS OF THE MULTID
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Index of authors A Aapro, M., 0377,
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Bahr, J., 0148 Bai, M., 1551 Baia,
Page 561 and 562:
Bottini, P.V., 1181 Botto, B., 0408
Page 563 and 564:
Chaidos, A., 0456, 0498, 0599, 0686
Page 565 and 566:
De Keersmaecker, K., 0442, 0875 De
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El-Sharkawy, N., 0016 Elwahidi, G.,
Page 569 and 570:
Garcia-Frade, J., 0346, 0680, 1105
Page 571 and 572:
H Haas, N., 0742 Haas, O.A., 0001,
Page 573 and 574:
Jaksic, B., 0127, 0446 Jaksic, O.,
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Körmöczi, G., 0848 Kornblau, S.,
Page 577 and 578:
Lin, L.-I., 0030, 0484 Lin, T., 012
Page 579 and 580:
Massé, A., 0249 Massó, P., 1287,
Page 581 and 582:
Musto, P., 0254, 0401, 0422, 0569,
Page 583 and 584:
Papadavid, E., 1442 Papageorgiou, E
Page 585 and 586:
Probatova, N., 0704 Prochazka, V.,
Page 587 and 588:
Rykavicin, O., 0504 Ryningen, A., 0
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Sirard, C., 0127, 0128 Sirigou, A.,
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Thiebaut, A., 0454 Thieblemont, C.,
Page 593 and 594:
Vincenzi, C., 1060 Viniou, N.-A., 0
Page 595 and 596:
Zouabi, H., 0503, 0999 Zoumbos, N.C
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12th Congress of the European Hematology ... - Haematologica

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