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12 th Congress of the European Hematology Association 1444 PROGNOSTIC FACTORS IN SECOND-LINE THERAPY FOR AGGRESSIVE NON-HODGKIN'S LYMPHOMA M. Stein, Z. Chameisi Rambam Health Care Campus, HAIFA, Israel Background. Seventy percent of patients with advanced, aggressive non-Hodgkin’s lymphoma [NHL] can achieve complete remission following 1st line treatment, although about half of these patients will relapse and will be treated with a 2nd line regimen. There are various studies concerning the importance of initial prognostic factors for the outcome of treatment and for the creation of an International Prognostic Index. Aims. The purpose of this study was to define prognostic factors for various outcome parameters (complete remission, time to tumor progression, survival) in patients with persistent/recurrent aggressive NHL undergoing 2nd line chemotherapy and their implementation in the therapeutic decision planning. Methods. This was a retrospective study of 70 patients (30 males, 40 females) ranging in age from 18-86 years (mean: 54 years) with recurrent (following complete remission) or persistent (primary refractory) aggressive NHL who were treated with CHOP (cyclophosphamide, adriamycin, vincristine, dexamethasone - conventional or high dose) as 1st line treatment. Second-line treatment included DVIP (cisplatin, VP-16 (etoposide), ifosfamide, dexamethasone), DAIP (cisplatin, VP-16, cytosine-arabinosid, dexamethasone) or DVIP-high dose methotrexate regimen. All patients had a follow-up of at least 1 year from the start of their salvage regimen. Results. The following parameters were analyzed for their influence on complete remission (CR) rate, time to tumor progression (TTP) and survival: performance status (PS),B symptoms, bulky disease, lactate dehydrogenase (LDH), hemoglobin and albumin levels, location/number of nodal and extranodal sites, and splenic involvement. CR was achieved in 46% and partial remission in 28% of patients. Median TTP and survival were 6 months and 10 months, respectively. The following parameters were associated with better TTP: high-dose chemotherapy (HD-CT), higher hemoglobin level at the onset of 2nd line treatment, and splenic involvement at initial diagnosis. Improved survival was associated with HD-CT, good PS before introduction of 2nd line chemotherapy and splenic involvement at initial diagnosis. Longer duration of CR following 1st line chemotherapy and higher initial hemoglobin level at initial diagnosis predicted higher CR rate with 2nd line chemotherapy. Conclusion. Assignment (or classification) of various risk factors in aggressive, recurrent or therapy-refractory NHL might have paramount importance in treatment decision making. Patients with poor predictive factors should be treated with a more intensive treatment schedule, such as HD-CT with bone marrow or peripheral blood stem cell support. 1445 PNEUMONITIS AND RENAL TOXICITY WITH SIROLIMUS BASED GVHD PROPHYLAXIS FOR RIC ALLOGENEIC HSCT A. Bryant, J. Moore, A. Dodds, S. Milliken, K. Fay, D. Ma St Vincent’s Hospital, SYDNEY, Australia Background and Aims. A challenge with reduced intensity conditioning (RIC) allografting is to adequately manage acute graft versus host disease (aGVHD) without negating a graft versus leukaemia/lymphoma (GVL) effect. Previous studies (Antin et al.) suggest reduced rates of aGVHD with sirolimus based GVHD regimens. The aim was to assess sirolimus based GVHD prophylaxis in RIC HSCT in a single transplant centre. Methods. The RIC included fludarabine 30 mg/m2 x5 and melphalan 140 mg/m2 x1. Intravenous Tacrolimus was administered at 0.02 mg/kg daily, oral sirolimus 1mg daily (for 28 days) and methotrexate 5 mg/m2 (days 1,3,6 and 11). Sirolimus dose was reduced to account for our use of azole antifungal prophylaxis. After the first 15 patients, tacrolimus was substituted with intravenous cyclosporin (1 mg/kg daily) because of renal toxicity and difficulties with drug monitoring and dosing. Results. Twenty-five consecutive patients with median age of 54 (37-67) and high risk features were enrolled. 13 had matched unrelated donors and 12 sibling donors. 72% of the patients survived at a median follow up of 351 days (70-1056). Median relapse free survival was 351 days (49-1055) and overall survival 356 days (70-1057). Seven died (4 sepsis, 3 relapsed disease). 15/25 is alive in complete remission and 3/25 is alive with relapsed disease. Transplant related mortality at 100 days was 8%. Grade 2-4 GVHD was seen in 11 of 13 (85%) unrelated donor RIC HSCT and 2 of 12 (17%) sibling HSCT. Toxicity from this regimen included renal impairment (13), thrombotic thrombocytopaenic purpura (3) and pneumonitis (2). Renal impairment was a major management 516 | haematologica/the hematology journal | 2007; 92(s1) problem in 13 patients with two requiring temporary renal dialysis. The two patients who developed sirolimus related pneumonitis required a temporary period of mechanical ventilation. Conclusions. This pilot study found that sirolimus based GVHD prophylaxis in RIC HSCT led to low transplant related mortality at 100 days with acceptable relapse free and overall survival for this poor risk group of patients. Secondly, the introduction of sirolimus did not significantly reduce rates of aGVHD in unrelated RIC HSCT. Thirdly, the combination of sirolimus and a calcineurin inhibitor resulted in significant toxicity. Finally, to our knowledge, this is the first report of sirolimus associated pneumonitis in bone marrow transplant patients, which has only been reported in solid organ transplant literature. Reference 1. Antin, J. etal. Sirolimus, tacrolimus, and low dose methotrexate for graftversus-host disease prophylaxis in mismatched related donor or unrelated donor transplantation. Blood. 2003;102:1601-1605. 1446 SEVERE HYPOXIA ENHANCES EX VIVO HAEMATOPOIETIC EXPANSION UNDER CLINICAL GRADE CONDITIONS M.P. Mariani, 1 A. Taddei, 1 F. Bambi, 1 M.G. Gelli, 1 S. Giuntoli, 2 M.G. Cipolleschi, 2 P. Dello Sbarba2 1 Azienda Ospedaliera Universitaria Meyer, FIRENZE; 2 Department of Experimental Pathology and, FIRENZE, Italy Background. Haematopoietic cells isolated from bone marrow or mobilized peripheral blood, to become suitable for therapeutical haematopoietic reconstitution, often require to be expanded ex vivo. Enhancement of stem cell self-renewal is the natural issue of such a procedure, as an increased number of stem cells is a key factor in the overall numerical expansion of the explanted cell population. In a number of studies carried out over the last 15 years, we demonstrated that very low oxygen tensions in vitro (severe hypoxia) help to preserve the stem cell potential within haematopoietic cell populations obtained ex vivo (Blood 82:2031- 2037, 1993; Leukemia 14:735-739, 2000). Severe hypoxia was shown to influence the balance between stem cell differentiation commitment and self-renewal in favour of the latter and to restrain the effects of cytokines boosting commitment and clonal expansion (Exp. Hematol. 30:67-73, 2002). Aims. The target of this study was the development of protocols for the in vitro expansion of haematopoietic potential under good medical practice (GMP) conditions, suitable for clinical use. Serumfree incubation media were therefore used, supplemented with a combination of stem cell-active cytokines, to incubate explanted haematopoietic populations in order to compare their in vitro expansion under severe hypoxia with that in normoxia. Methods. Cells were obtained from mobilized peripheral blood of 3 donors. CD34 + cells were isolated from buffy-coat by the Miltenyi Biotec indirect immunomagnetic technique, using for the first passage the midi column and for the second the mini column. Cells were then analysed by flow cytometry using anti-CD34,-CD133, -CD61, -CD3, -CD19 antibodies. The purity of the isolated CD34 + cells was 35-75%. Cells were cultured in the HP01 medium (MacoPharma), in the presence of the FKT6 cytokine combination, including Flt3-ligand, Stem Cell Factor/Kit-ligand, ThromboPoietin and Interleukin-6. Incubation under severe hypoxia (0.1% O2) was carried out in a water-saturated Ruskinn Concept 400 anaerobic incubator, flushed with a preformed gas mixture (0.1% O2, 5% CO2, 95% N2); incubation in normoxia (21% O2) was carried out in a 5% CO2, 95% air, water-saturated atmosphere. Culture expansion was measured after 14 days of incubation, with respect to either the overall number of viable cells or the number of colony-forming cells (CFC), as determined following cell transfer to secondary FKT6-supplemented MethoCult (StemCell Technologies Inc.) semisolid cultures and a further 7-day incubation therein, in any case in normoxia. Results. Haematopoietic expansion in hypoxia was 2.8-fold higher than in normoxia as determined by counting the overall number of viable cells, and 3.5-fold higher as determined by counting the number of CFC. Conclusions. In the presence of the FKT6 cytokine combination, incubation in severe hypoxia resulted an efficient method to markedly improve the expansion of haematopoietic cell populations under clinical grade conditions.
1447 THE IMPACT OF DISPARITY IN SHORT TANDEM REPEATS (STRS) ANALYSIS ON THE OUTCOME OF ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION (ALLO-HCT) FROM HLA-IDENTICAL SIBLING DONORS E. Serbest, P.T. Topcuoglu, K.D. Dalva, E.S. Soydan, O.A. Arslan, M.O. Ozcan, T.D. Demirer, H.A. Akan, N.K. Konuk, A.U. Uysal, O.I. Ilhan, G.G. Gurman, M.B. Beksac, M.A. Arat Ankara University, ANKARA, Turkey STRs were widely used for monitoring of chimerism after allo-HCT. The effect of STR disparity on allo- HCT has been analyzed in a few studies. We aimed to evaluate the impact of STR disparity on allo-HCT outcome retrospectively in our single center cohort. Between Sep 2000 and May 2005, total 88 patients (F/M:45/43) underwent allo-HCT from an HLA-identical sibling donor (PB/BM: 71/17) Median age was 34 ys (16-64). Multiplex PCR was performed to amplify 16 STR loci (D3S1358, HUMvWA, D16S539,D2S1338, Amelogenin,D8S1179, D21S11,D18S51, D19S433, THO1, FGA, D7S820, CSF1PO, D13S317, TPOX, D5S818) (ABI Prism 310). These loci were classified as full- and partial-matched, and full mismatched(mm) between donors and recipients. Results. D2S1338 locus (full matched, 21.6%-n=19; partial matched 50%-n=44 and full mm 28.4%-n=25) was the most informative one, but CSF1PO (43.2%, n=4; 52.2%, n=46 and 4.5%, n=38, respectively) was the least. The general incidences of acute(a) severe and chronic(c)GvHD were 29.5% and 61.8%. Full mm in TPOX locus (p=0.04) led to more acute severe GvHD than in partial matched or full matched loci. However, full mm in D2S1338 locus significantly decreased the incidence of aGvHD in patients with partial matched and full matched loci (5.3%, 29.5% and 48%, respectively p=0.009). However, more cGvHD was only seen in the patients with full matched D7S820 donors (p=0.04). In our cohort,2-year probability of disease free survival (DFS) and overall survival(OS) were 53.1±5.9% and 66.2±5.6%, respectively in mean 46.5±3.8 moths of follow-up. Although the full-mm in D8S1179 locus increased the relapse incidence (62.5% vs 33.3% vs 18.8%, p=0.04), there was a tendency to a decrease of DFS in patients with full-mm CSF1PO or partial matched D7S820 (p=0.06). Early transplant-related mortality increased in patients with D7S820 full-mm (p=0.02). This unfavorable effect was reflected on OS (p=0.002).Besides, patients with fullmm TPOX locus had a decreased probability of OS. TPOX and D7S820 were also less informative resembling CSF1PO.We were not able to show any correlation of stem cell source, conditioning regimen, donor or recipient age, and sex mm on early TRM, aGVHD, cGVHD, and OS rate. Conclusions. The presence of STR disparity could be associated with the development of complications and unfavorable survival probability after allo-HCT from HLA-identical siblings.This analysis approach should be repeated on partial matched and unrelated donor transplants. 1448 EVALUATION OF THE SURVIVAL OF INPATIENT WITH ALL AND INTERMEDIATE RISK TREATED ACCORDING TO PETHEMA-96 PROTOCOL C. Martin, I. Pérez de Soto, E. Gil, P. Cerezuela, F. De la Cruz, J.M. Pérez-Hurtado HHUU Virgen del Rocio, SEVILLE, Spain Introduction. Acute lymphoblastic leukemia (ALL) is the most common cancer in chilhood and represents around the 25% of neoplasias diagnosed in younger children of 14 years old. They are treated according to defined risk groups based in clinical and laboratory features. For children who seem to have less cure likelihoods, more aggressive treatment generally is given. Materials and Methods. Descriptive study in patient with ALL of intermediate risk treated in Pediatric Oncohaematological Service of our centre according to the PETHEMA-96 protocol. Period: August 1998-January 2007. Results. 38 inpatients (52% girls) with mean age of 4,8 years (1 to 14 years), have been evaluated. The most frequent clinical presentation were adenopathy and the hepatomegaly (57,9%), with anaemia (Hb< 8 g/dL) in 36,8% (14) and leukocytosis (>50.000/mm3 ) in 26,3% (10). L1 are the 73,7% (according to the FAB classification), B-II (EGIL classification) 65,8% and a 13,1% were immunophenotype T. Cytogenetic study was performed in the 68,4% (26) of the inpatients being normal the 34,4% and pathological the 65,6% remaining, emphasizing the presence of hypodiploidies (13,2%), hyperdiploidies (18,4%) and complex karyotype in the 15,8%. The molecular biology study (BCR/ ABL, E2A/ PBX1, MLL/AF4, TEL/AML) was realized of uneven way in the studied inpatients (between the 28,9% and the 65,8% of the cases) finding TEL/ AML reordering in 2 inpatient (5,3%). During the treatment the 7,9% (3) relapsed and a 13,2% (5) died, 2 in the induction 12 th Congress of the European Hematology Association treatment (both by infectious causes) and the 3 remaining during relapse. The maximum follow-up is 101 months (mean 52 months). The complete remission (CR) rate was 86,8% having completed treatment the 63,2% (24). Conclusions. Complete continuous remission in childhood with risk factors agreements with PETHEMA-96 protocol is similar to the obtained inpatients of standard risk that they have received another treatment protocols. 1449 BONE MARROW/PERIPHERAL BLOOD POSITIVITY OF BCL-2/IGH REARRANGEMENT IN PATIENTS WITH FOLLICULAR LYMPHOMA BEFORE TREATMENT HAS NO PROGNOSTIC SIGNIFICANCE D. Belada, 1 L. Smolej, 2 M. Beranek, 3 D. Dvorakova, 4 P. Stepankova, 2 J. Bukac, 5 J. Maly2 1 University Hospital Hradec Kralove, HRADEC KRALOVE; 2 University Hospital and Medical School, HRADEC KRALOVE; 3 Institute of Clinical Biochemistry, HRADEC KRALOVE; 4 Dept.of Internal Medicine-Hematooncology, UNI- VERSITY HOSPITAL BRNO; 5 Institute of Biophysic and Biostatistics, MED- ICAL SCHOOL, HRADEC KRALOVE, Czech Republic Background. Bcl-2/IgH rearrangement represents a typical cytogenetic aberration in patients with follicular lymphoma where it occurs in 40- 90% of the cases at diagnosis. However, its clinical impact remains unclear. Aims and methods. The aim of this study was to evaluate Bcl- 2/IgH rearrangement in 50 patients with follicular lymphoma before treatment by means of nested PCR technique and to correlate molecular genetic findings with clinical characteristics and results of treatment in subgroups-with vs. without Bcl-2/IgH rearraangement. 91 samples from peripheral blood and/or bone marrow from fifty patients (median age, 56.5 years; male/female ratio: 33/17) were analysed. Samples from both compartments were available in 41 cases. Bcl-2/IgH rearrangement was analysed by nested PCR technique for both major breakpoint region (MBR) and minor cluster region (mcr). Results. Twenty-six out of fifty patients (52%) were positive for Bcl-2/IgH rearrangements; 24 in MBR and 2 in mcr, remaining 24 patients were negative. Regarding the initial characteristics, patients under 65 years were more likely to be Bcl-2/IgH positive than negative (88% vs. 58%, p=0.02). Patients with initial bone marrow involvement were also more often Bcl-2/IgH positive than negative (88% vs. 58%, p=0.02). High correlation between Bcl-2/IgH rearrangement in peripheral blood and bone marrow was noted as well as correlation between PCR Bcl-2/IgH detection and immunohistochemistry bcl-2 protein detection in bone marrow. No differences were found according to initial Bcl-2/IgH status with respect to clinical course of disease in terms of complete remission achievement, improved overall survival or progression-free survival in comparison with Bcl-2/IgH negative group. Summary. Molecular positivity of Bcl-2/IgH rearrangement in patients with follicular lymphoma before treatment had no impact to prognosis of the disease although additional breakpoint regions may play important role. Further investigations in this field are needed to determine definitive role of this molecular finding to prognosis of patients with follicular lymphoma. This work was supported by research project MZO 00179906 from Ministry of Health, Czech Republic, and by grant NR/9453-3 from Internal Grant Agency, Ministry of Health, Czech Republic. 1450 HEMATO- AND IMMUNOPOIESIS REGENERATION OF LETHALLY IRRADIATED MICE BY CELLS ISOLATED FROM INTESTINAL EPITHELIAL LAYER L. Vedina, 1 S.V. Sennikov, 1 V.A. Trufakin, 2 V.A. Kozlov1 1 Institute of Clinical Immunology, NOVOSIBIRSK; 2 Institute of Physiology, NOVOSIBIRSK, Russian Federation Background. The study of stem cell plasticity has large significance in development of the cellular therapy. Recent studies shown that adult stem cells are able to differentiate into cellular types of different tissues. Many adult non-hematopoietic stem cells is known to have hematopoietic potential. As shown earlier, cells of the intestinal epithelial layer have ability to form splenic hematopoietic colonies (CFU-9). Aim. This study aims to investigate ability of intestinal epithelial layer cells (IELC) to hemo- and immunopoiesis regeneration of lethally irradiated mice. Methods. Recipient animals were (CBAxC57Bl/6)F1 mice that were lethally irradiated with 9 Gy given in one dose. IELC or bone marrow cells (BMC) were introduced intravenously. Control group was non-irradiated mice. At 1, 3 and 6 months after transplantation, delayed-type hypersensitivity reaction, IgM antibody formation, blood cells counts were investigat- haematologica/the hematology journal | 2007; 92(s1) | 517
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haematologica the hematology journa
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Information for readers, authors an
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EHA Executive Board E. Hellström-L
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Poster session I POSTER SESSION POS
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12 th Congress of the European Hema
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dasatinib. Methods. We studied Ikar
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Expression of the oncogene H-Ras an
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is the gene for the erythropoietin
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safety of a slow-release liposomal
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0029 OUTCOME OF THE TREATMENT OF AD
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drug-induced apoptotic response of
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41% in the PI3K- group (p=0.001). I
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Acute myeloid leukemia - Clinical I
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to 60 years (n=116, or 72%) receive
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0056 PROGNOSTIC SIGNIFICANCE OF FLT
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Anemia and Bone marrow failure 0061
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tified with the current protocol. S
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new cases of lead poisoning due to
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icance, from baseline to week 6 (p
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0086 THROMBELASTOGRAPHIC CHART RELI
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trials. The aim of this retrospecti
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tant function in this disease, nega
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ed to a favorable outcome. Bialleli
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stronger levels of p21 in the cell
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hematological centers in one countr
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ure 1). Conclusions. Results for re
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patients. After a median follow-up
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Cytogenetics and Molecular diagnost
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0135 ROUTINE DETECTION OF CYTOGENET
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(MMolR, defined as a BCR-ABL x 100
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0146 ARSENIC TRIOXIDE INDUCES ACCUM
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tinguish between genotypic B-cell l
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Genomics and proteomics 0158 PLASMA
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0164 EVALUATION OF MULTIPLEX LIGATI
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each patient’s replicate conditio
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0174 RELATION BETWEEN LOW PML-RARα
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0179 ESHAP VS GIN AS SALVAGE AND MO
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Immunology and gene therapy 0184 EA
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Cell viability was not affected by
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month is not relevant to chronic Gv
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Infection and supportive care I 020
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0206 POTENTIAL ROLE OF CMV IN THE O
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3H-thymidine uptake in cell culture
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0217 TUBERCULOSIS AMONG A COHORT OF
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0222 COMPARISON OF IWG 2006 AND IWG
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tem (IPSS) to h-MDS was also invest
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PCH97-19) were studied. Conventiona
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of erythroid colonies was reduced i
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0245 POTENT AND SELECTIVE INHIBITIO
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0250 INACTIVATION OF SUPPRESSOR OF
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Bortezomib 1.3 mg/m 2 days 1,4,8,11
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Response was defined according to E
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G-CSF can be used in neutropenic pa
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ence and functional activity of CD8
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itating tumor development, or engag
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phoma and SNT-13, -15 were establis
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usage (2/20 ie 10%) were observed.
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0294 MYCOSIS FUNGOIDES. IMMUNOHYSTO
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(range, 1-6) and 11 treatment cycle
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0306 RISK-ADAPTED IMMUNOCHEMOTHERAP
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functional activity was confirmed b
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No major toxicity, neither hematolo
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enewal potential of X-RAR-positive
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(50-99) respectively. Serial analys
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cell-interaction, adhesion and acti
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0340 ALTERED FIBRIN CLOT STRUCTURE
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Conclusions. This study demonstrate
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0354 FACTOR V LEIDEN HOMOZYGOUS GEN
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Results. From July 2005 through Mar
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0364 CLINICAL EFFICACY OF OXALIPLAT
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one marrow and peripheral blood ste
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ecently suggested (Boissel et al.,
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0378 SAFETY AND EFFICACY OF THE TER
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Cytogenetics and molecular diagnost
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0385 CYTOPLASMIC MUTATED NUCLEOPHOS
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0390 ELTROMBOPAG RAISES PLATELET CO
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factor for the achievement of CR wa
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The cases of RAS showed two peaks o
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is 85%. Seven out of the 25 relapse
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0409 FRACTIONATED RADIOIMMUNOTHERAP
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0414 COMPARATIVE ANALYSIS OF THE CO
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successfully managed with GM-CSF di
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49% for PCR positive patients (95%
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+8 (1 PR+1 HI) and 14/24 pts with c
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(e.g. bcr-abl leading to CML). CSC
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0438 TERC MUTATIONS ANALYSIS IN PAT
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observed in all mice. Analysis of l
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ex-vivo expansion of HUCB-derived H
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ic kidney disease in univariate or
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One hundred eleven CN AML patients,
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to asses intestinal epithelial dama
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genesis of acute myeloid leukaemia
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polymorphism at nucleotide 4889 of
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expression along with a decreased C
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0487 MUTATIONAL STATUS OF NUCLEOPHO
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previously reported, a single cours
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0497 SINGLE AGENT CLORETAZINE (VNP4
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ly received melphalan-based chemoth
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were similar among the 3 groups. Ho
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Methods. Several read-out systems w
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0518 SERUM AND CELLULAR EXPRESSION
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0523 DNA REPAIR INHIBITION IN RESTO
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held true when BMI-1 expression was
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Ph + cells in the bone marrow). We
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derivative chromosome (4p16, 7p14,
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0545 STABILIZED BONE MARROW IS NOT
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obtained in low (Sokal) risk patien
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median dose intensity being 800 (21
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from pivotal clinical trials. Metho
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Cytogenetics and Molecular diagnost
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to set up and optimize a D-HPLC-bas
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0576 WESTERN BLOT IDENTIFICATION OF
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Basic disease was AML (n=5), ALL (n
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0588 EXTRACORPOREAL PHOTOPHORESIS F
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acquire a cytolytic capacity agains
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informed vignettes describing healt
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using CHOP-21 in the UK, pegfilgras
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0609 SOFT TISSUE COMPLICATIONS IN P
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inding lectin (MBL) gene by polymer
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all infection rate (p=0.12) as well
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Myelodysplastic syndromes II 0623 M
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formation (in total 28 samples). Ti
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sion. In addition, confocal analysi
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Myeloproliferative disorders - Clin
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open-label, multi-centre study enro
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iopsies after 6 and 12 months treat
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Myeloproliferative disorders Chroni
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ash, muscolar cramps, diarrhoea, he
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induced significant apoptosis (mean
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Myeloma and other monoclonal gammop
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the therapy of choice for POEMS is
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er patient does not indicate such t
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Myeloma and other monoclonal gammop
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secutive patients with MM, referred
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whether gene expression values may
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0705 THE SHIFT OF TREATMENT FOR NAS
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0710 CLINICO-PATHOLOGICAL FEATURES,
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patients presented a stage IV disea
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plete remission or recurrent diseas
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known at NHL diagnosis, were includ
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0731 THE IMPACT OF HIV ON NON-HODGK
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patients had died of their underlyi
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scripts and proteins most affected
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modulated after 24 h (37 up- and 59
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0753 A SUSTAINED REMISSION OF IDIOP
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and treatment, has rarely been syst
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uncontrolled massive bleeding affec
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Results. A total of 396 patients we
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C30 questionnaire, and the correspo
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wave length of light of reflected r
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0783 PREVALENCE OF MEMBRANE PROTEIN
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erozygous mother has a more severe
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0794 CARDIAC MANIFESTATIONS IN A BR
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0799 INEFFECTIVE ERYTHROPOIESIS IN
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p=0.014 and p=0.003, respectively).
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0809 CURRENT APPROACH TO CHELATION
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Thrombosis II 0814 UNSUSPECTED PULM
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the 97.5th percentile (5.2 U/mL) ge
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symptoms of DVT, 3 (7.89%) previous
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Transfusion medicine and vascular b
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tions (most bacterial, 2 malaria, 6
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0844 INCREASED LEUKOCYTE-PLATELET I
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0851 CORD BLOOD DERIVED MESENCHYMAL
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SIMULTANEOUS SESSION II Chronic mye
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0862 COMPARISON OF DASATINIB TO HIG
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0867 COMPREHENSIVE GERIATRIC ASSESS
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0872 MN1 INDUCES LEUKEMIA IN MICE A
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0877 PAX5/TEL TRANSDUCED PRE-BI CEL
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0882 CISPLATIN INDUCES THROMBIN GEN
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have an early manifestation of typi
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0892 INTEGRATION OF GENOME WIDE SNP
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0897 THE PHENOTYPE OF JAK2V617F MUT
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gest diverse sequences of NPM mutan
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2004 to January, 2006. At enrollmen
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with a p value of ≥ 0.10. Sets of
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BRIC 126 and 4N1K) in cells lacking
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sclerosis[NS] and 12 Mixed cellular
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0927 MK-0457, A NOVEL MULTIKINASE I
Page 357 and 358:
Publication Only 0933 CLINICAL FEAT
Page 359 and 360:
HSCT from the available Asian as we
Page 361 and 362:
that the incidence of JAK2 mutation
Page 363 and 364:
without type 2 diabetes. Methods. T
Page 365 and 366:
pts (38.8%) that were isolated (abs
Page 367 and 368:
y using the Miltenyi CD34 isolation
Page 369 and 370:
0969 COMPARISON OF CD25 IMMUNOHISTO
Page 371 and 372:
cytes was 24 days (range 8-32 days)
Page 373 and 374:
a cytogenetic hallmark for M4/M5 su
Page 375 and 376:
normal human BM B progenitor cells
Page 377 and 378:
0994 INCIDENCE OF INVASIVE ASPERGIL
Page 379 and 380:
3 of disease relapse.TRM at day+100
Page 381 and 382:
survival of five years. This dismal
Page 383 and 384:
1011 FLOW CYTOMETRIC DNA INDEX AND
Page 385 and 386:
1018 THE EFFECT OF THE SUGARBAKER P
Page 387 and 388:
1024 KIR/HLA CLASS I MISMATCHING AN
Page 389 and 390:
ment details and thrombotic histori
Page 391 and 392:
1036 INCIDENCE AND SPECTRUM OF INFE
Page 393 and 394:
tinely by our stem cell lab prior t
Page 395 and 396:
tion to a translocation t(5;14)(q35
Page 397 and 398:
ment of CML and induces a high rate
Page 399 and 400:
due to reactivation and/or progress
Page 401 and 402:
1063 ABNORMAL METHYLATION STATUS OF
Page 403 and 404:
1069 CLINICAL RELEVANCE OF REGULATO
Page 405 and 406:
1076 SERUM LEVELS OF SOLUBLE HLA CL
Page 407 and 408:
patient is still undergoing intensi
Page 409 and 410:
nificant MVD differences were detec
Page 411 and 412:
dictor of OS (p=0.004). High dose t
Page 413 and 414:
1099 ALTERATIONS IN THE NATURAL KIL
Page 415 and 416:
1105 CYTOGENETIC ABNORMALITIES IN 3
Page 417 and 418:
1110 CONSTITUTIVE ACTIVATION OF STA
Page 419 and 420:
efficacy results with a well-tolera
Page 421 and 422:
unmutated VH genes, and high and lo
Page 423 and 424:
Aims. Aim of this study was to pred
Page 425 and 426:
tested across a wide range of human
Page 427 and 428:
were incidentally diagnosed (52%).
Page 429 and 430:
ß2GP1 may be considered as determi
Page 431 and 432:
characterized in 198 β thalassaemi
Page 433 and 434:
1155 PLATELET AGGREGATION IN CHILDR
Page 435 and 436:
to-pelvic or perineal trauma. No me
Page 437 and 438:
in age. High prevalence of LBM amon
Page 439 and 440:
ecause some of the patients were or
Page 441 and 442:
of the drug is crucial to allow lon
Page 443 and 444:
egarding cost analysis of ASCT in G
Page 445 and 446:
ID Allo-BMT, 1 family one mismatche
Page 447 and 448:
admitted to ICU were discharged des
Page 449 and 450:
events -Postoperative states: 9,19%
Page 451 and 452:
efficacy and decreased atherosclero
Page 453 and 454:
1217 INCIDENCE OF EARLY STAGE IDIOP
Page 455 and 456:
1691GA and 1 homozygous 1691AA. The
Page 457 and 458:
1230 ASSOCIATION OF HEPARANASE GENE
Page 459 and 460:
posed, was: DF = (CD43%+FMC7%+CD79b
Page 461 and 462:
treatment of acute promyelocityc le
Page 463 and 464:
loaded group and 35 (70%) were non-
Page 465 and 466:
mild. Fas and soluble Fas ligand le
Page 467 and 468:
1265 POSACONAZOLE THERAPY IN REFRAC
Page 469 and 470:
ly express the cytoplasmic (inactiv
Page 471 and 472:
findings confirmed the significant
Page 473 and 474: a less favorable prognosis. Interes
Page 475 and 476: disease (HD), 4 patients (9%) with
Page 477 and 478: 1295 HEMOPHAGOCYTIC LYMPHOHYSTIOCYT
Page 479 and 480: phamide 750 mg/m 2 on day 1, vincri
Page 481 and 482: nomenon is unclear. It has been sug
Page 483 and 484: oped mild thrombocytopenia (platele
Page 485 and 486: gle dose of 54mg/m 2 rituximab furt
Page 487 and 488: patients (pts), 36 male, with acute
Page 489 and 490: esulting alterations of the endothe
Page 491 and 492: (range 1-7) and 28,6% of patients h
Page 493 and 494: three decades. In vivo, Ara-C is tr
Page 495 and 496: statistical analysis. Results. Seve
Page 497 and 498: Results. Though there was no recogn
Page 499 and 500: 2% and 19% of patients with or with
Page 501 and 502: were older than 65 y) which can be
Page 503 and 504: 1376 RESVERATROL INDUCED P53 MEDIAT
Page 505 and 506: median time of 21 days to reach >0.
Page 507 and 508: ly. Conclusions. 1. Combined intens
Page 509 and 510: to the presence of IVS1-6 mutation
Page 511 and 512: fy predictive factors for these abn
Page 513 and 514: acute leukemia. However, we cannot
Page 515 and 516: agents. They involve primarily the
Page 517 and 518: voriconazole for 2 months followed
Page 519 and 520: typed using a commercially availabl
Page 521 and 522: low up of ABL KD mutations’ level
Page 523: with development of BC/AP. 2. EVI-1
Page 527 and 528: three had visual field defects, two
Page 529 and 530: acquired mutation most prone to cau
Page 531 and 532: 1466 ROS GENERATION AND APOPTOSIS I
Page 533 and 534: 1473 DIARRHEIC SYNDROME, A CLINICAL
Page 535 and 536: gene fusion is an independent progn
Page 537 and 538: 1484 EPIDEMIOLOGY AND RESPONSE TO T
Page 539 and 540: 1492 FREQUENCY OF MEDITERRANEAN GLU
Page 541 and 542: immune globulin was administered at
Page 543 and 544: maintained on Imatinib 400 mg. Afte
Page 545 and 546: Hodgkin’s disease is well known,
Page 547 and 548: gram provided a unique chance to de
Page 549 and 550: even when ADP-induced plt activatio
Page 551 and 552: medullary involvement of multiple m
Page 553 and 554: 1540 ADMINISTRATION OF G-CSF AND CH
Page 555 and 556: 1548 QUALITY ANALYSIS OF THE MULTID
Page 557 and 558: Index of authors A Aapro, M., 0377,
Page 559 and 560: Bahr, J., 0148 Bai, M., 1551 Baia,
Page 561 and 562: Bottini, P.V., 1181 Botto, B., 0408
Page 563 and 564: Chaidos, A., 0456, 0498, 0599, 0686
Page 565 and 566: De Keersmaecker, K., 0442, 0875 De
Page 567 and 568: El-Sharkawy, N., 0016 Elwahidi, G.,
Page 569 and 570: Garcia-Frade, J., 0346, 0680, 1105
Page 571 and 572: H Haas, N., 0742 Haas, O.A., 0001,
Page 573 and 574: Jaksic, B., 0127, 0446 Jaksic, O.,
Page 575 and 576:
Körmöczi, G., 0848 Kornblau, S.,
Page 577 and 578:
Lin, L.-I., 0030, 0484 Lin, T., 012
Page 579 and 580:
Massé, A., 0249 Massó, P., 1287,
Page 581 and 582:
Musto, P., 0254, 0401, 0422, 0569,
Page 583 and 584:
Papadavid, E., 1442 Papageorgiou, E
Page 585 and 586:
Probatova, N., 0704 Prochazka, V.,
Page 587 and 588:
Rykavicin, O., 0504 Ryningen, A., 0
Page 589 and 590:
Sirard, C., 0127, 0128 Sirigou, A.,
Page 591 and 592:
Thiebaut, A., 0454 Thieblemont, C.,
Page 593 and 594:
Vincenzi, C., 1060 Viniou, N.-A., 0
Page 595 and 596:
Zouabi, H., 0503, 0999 Zoumbos, N.C
Page 597 and 598:
Page 599 and 600:
Page 601 and 602:
Page 603:
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