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12 th Congress of the European Hematology Association gy. There are not significant differences between different therapeutical approaches in terms of the percentage of CR. IVIG and HDMP at 7.5 mg/Kg for 4 days seem to be the best treatments to reach as soon as possible a safe platelet level ≥30×10 9 /L (3-6 days), and a CR (7-11 days). Among NR (chronic) patients, seven have been splenectomized and only 3 reached a stable CR. We never observed a significant toxicity, nor adverse events related to the treatment. Conclusions. Our experience shows that there are no statistically significant differences in terms of CR between the different treatments, even considering that more than 70% of relapses and 39% of NR children can be cured with further treatments. However, the main target of the treatment is to reach safe platelet levels ≥30×10 9 /L as soon as possible to avoid life-threatening risks (spontaneous bleeding and trauma for young children) or parent anxiety. Therefore, IVIG (0,4 mg/kg) and HDMP (7,5 mg/kg/day) seem to be the best options; the low costs of HDMP and its safety need to be considered. The high percentage of CR after any kind of first line treatment, let us to suppose that it is possible to obtain a spontaneous recovery in the great majority of patients also without treatment. Therefore, the extension of the 'wait and see' strategy for as many patients as possible could be important. In children, in comparison to ITP adults, the splenectomy cannot be considered an usual therapy and not always a successful procedure. 0751 ITP INCIDENCE AND MORTALITY IN UK GENERAL PRACTICE RESEARCH DATABASE J. Kaye, 1 M. Schoonen, 2 J. Fryzek2 1 2 Boston University, LEXINGTON, USA; Amgen, UXBRIDGE, United Kingdom Background. ITP is an autoimmune disease characterized by low platelet counts and an increased risk of bleeding. The epidemiology of ITP in the UK has not been well characterized. The General Practice Research Database (GPRD), which comprises computerized general practice medical records for a population-based cohort of approximately five million residents of the UK, provides an opportunity to quantify the occurrence and outcomes of ITP in the general population. Aims.1. Estimate the incidence of ITP in the UK; and 2. Estimate the survival of patients with incident ITP compared to the population without ITP. Methods. Incident cases of ITP during 1990-2005 were identified in the GPRD and matched to comparison subjects by sex, year of birth, and index date. Total person-time contributed by all subjects in the GPRD population was used as the denominator for incidence calculations (with censoring when patients developed ITP, transferred out of their practice, or died). We analyzed changes in incidence over time using Poisson regression. We estimated survival by the Kaplan-Meier method and compared survival among incident ITP cases and their matched comparison subjects using the log-rank test and proportional hazards regression. Results. We identified 1,146 incident ITP cases and 5,715 matched comparison subjects without ITP. The crude (average) incidence of ITP was 3.9/10 5 person-years (py). The incidence was 4.4/10 5 py in females and 3.4/10 5 in males. The incidence by age was bimodal with highest values under 18 years and in the elderly. The age- and sex-adjusted incidence of ITP increased an average 5% per year (cumulative increase approximately two-fold during the 15-year study period). During a median 3.4 years of follow-up in the GPRD (interquartile range 1.5-6.0 years, maximum 15 years), 140 ITP cases (12.2%) and 482 comparison subjects (8.4%) died (p=0.0001). The estimated survival for ITP cases at 5 years was 87% (95% confidence interval [CI] 84-89%) and at 10 years was 78% (95% CI 74-82%). Adjusted for age and sex, the hazard ratio for death associated with ITP was 1.6 (95% CI 1.3-1.9). Ninety-six percent of deaths among ITP cases occurred in those older than 45 years. There was no significant survival difference between males and females. Conclusions. This study provides estimates of ITP incidence and mortality in the UK. ITP incidence recorded by general practitioners has increased substantially during the past 15 years. Further work is needed to determine whether this reflects a true increase in the incidence of ITP in the UK population, better detection, changing criteria for diagnosis, increased recording by general practitioners, or a combination of factors. Patients with ITP have approximately 60% higher mortality than sexand age-matched comparison subjects without ITP. This increased risk of death with ITP is largely concentrated in middle-aged and elderly patients. We are extending our study to explore causes of death among patients with ITP in the UK. 280 | haematologica/the hematology journal | 2007; 92(s1) 0752 A CASE OF AMEGAKARYOCYTIC THROMBOCYTOPENIA WITH RADIO-ULNAR SYNOSTOSIS SYNDROME, SUCCESSFULLY TREATED WITH ALLOGENEIC BONE MARROW TRANSPLAN- TATION M. Sugita, Y. Yokokawa, H. Yoneyama, T. Kaneko Tokyo Metropolitan Kiyose Childrens Hos, TOKYO, Japan Background and Aims. Bone marrow failure syndromes can be associated with abnormalities of skeletal defects. Since Thompson et al. (2000) have described two families of amegakaryocytic thrombocytopenia with radio-ulnar synostosis at first, which has been distinguishable from other congenital hyporegenerative thrombocytopenic disease or syndromes such as congenital amegakaryocytic thrombocytopenia, Fanconi’s anaemia, thrombocytopenia and absent radii (TAR), and is said to be associated with a point mutation in exon2 of HOXA11 gene. Currently, stem cell transplantation is considered to be the only curative approach. We describe the case of an 1-year old girl with amegakaryocytic thrombocytopenia with radio-ulnar synostosis syndrome. Methods and Results. The patient was born to parents of Japanese and presented systemic petichiae at birth. Laboratory findings showed with leukocyte count of 17.1×109 /L with no abnormal cells. The hemoglobin was 12.9 g/dL and the platelet count was 8.0×109 /L. She had clinodactylies of the fifth digit on both hands and limited pronation and supination of both upper extremities. A bone marrow at 3 days of age showed normocellular marrow with the normal maturation of erythroid and myeloid elements, but the absence of megakaryocytes and radiographic examination revealed bilateral proximal radial-ulnar synostosis (Figure 1). To make sure the diagnosis, DNA sequence analysis was also performed in search of HOXA11 mutation. With those findings, she was diagnosed as having amegakaryocytic thrombocytopenia with radioulnar synostosis syndrome. The platelet count remained bellow 1.0 ×109 /L and pancytopenia progressed gradually at the age of 5-months. At the age of 1-year and 6-months, she underwent allogeneic bone marrow transplantation (allo-BMT) from an HLA-identical unrelated donor. The Conditioning regimen consisted of total lymphoid irradiation, fludarabine, cyclophosphamide and anti-thymocyte globulin. FK506 and short-term methotrexate were used for graft-versus-host disease (GvHD) prophylaxis. The number of infused nucleated cells was 6.9×108 /kg. Time to achieve a granulocyte count > 0.5×109 /L and a platelet count > 50×109 /L was 16 days and 27 days, respectively. One month after BMT, a bone marrow examination showed complete remission with 100% donor type chimerism. During the course, she developed acute GvHD(skin; grade II) and was treated with prednisolone, successfully. A bone marrow examination continues to show complete remission with follow-up of 9 months after allo-BMT. Conclusions. Allo-BMT from an HLA-identical unrelated donor is a curative and suitable approach for patients with amegakaryocytic thrombocytopenia with radio-ulnar synostosis, who do not have HLA-identical sibling donors. In our case, the point mutation in HOXA11 gene was not found, which may suggest that there is a co-factor modulating HOXA11 expression and this case is possibly a subtype of this syndrome. Careful clinical course watching is required if another complications or the disease relapse will occur again. Figure 1. Forearm radiograph shows raio-ulnar synostosis.
0753 A SUSTAINED REMISSION OF IDIOPATHIC THROMBOCYTOPENIC PURPURA AFTER HELICOBACTER PYLORI ERADICATION: A LONG TERM FOLLOW-UP N. Suvajdzic, 1 B. Stankovic, 2 V. Artiko, 3 T. Cvejic, 4 V. Bulat, 4 M. Colovic, 1 D. Boskovic 1 1 Institute of Hemathology, BELGRADE; 2 Rehabilit.Center for hematol.pts, IVAN- JICA; 3 Institute of Nuclear medicine, CCS, BELGRADE; 4 Inst. of Gastroenterology, CCS, BELGRADE, Serbia Background. Several studies have described increase of the platelet count among patients with chronic idiopathic thrombocytopenic purpura (ITP) following H. pylori eradication. However, in most of these studies the median follow-up after eradication was less then a year. Aims. A long term monitoring of the platelet count after H. pylori eradication in adult H. pylori- positive ITP patients is performed in order to evaluate whether the eradication of H. pylori is associated with sustained ITP remission. Patients and Methods. 39 H. pylori-infected adult ITP pts. (9 male, 30 female; median disease duration 7 years; median age 54 years; mean platelet count 68×10 9 /L; 7refractory; median follow-up 36 months) entered the prospective study between February 2002-December 2006. The diagnosis of ITP was made according to the ASH Guidelines. H. pylori infection was assessed by C14-urea breath test (UBT) in all patients and in 24/39 was also confirmed by histology of gastric biopsy. All immunosuppressive drugs were withdrawn at least 1 month before examination. 32 H. pylori-positive patients were treated with: clarithromycin 500 mg BD, amoxycillin 1 g BD and pantoprazole 40 mg BD for 7 days. Amoxycillin was replaced with metronidazole 500 mg TDS in penicillin-allergic patients. Eradication of infection was assessed by UBT 2 months after treatment completion and at the end of follow-up. Platelet count was monitored monthly and assessed at 3 and 6 months after the end of treatment, then every 3 month. A complete response (CR) was defined as a platelet count of >150×10 9 /L, and a partial response (PR) as a platelet count of >50×10 9 /L with an increase of >30×10 9 /L with respect to the pretreatment value. The remaining patients were considered with no response (NR). Data were analyzed by t test; percentages were compared by χ 2 test (Fischer exact test for value ″5); a p-value
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haematologica the hematology journa
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Information for readers, authors an
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EHA Executive Board E. Hellström-L
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Poster session I POSTER SESSION POS
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12 th Congress of the European Hema
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dasatinib. Methods. We studied Ikar
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Expression of the oncogene H-Ras an
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is the gene for the erythropoietin
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safety of a slow-release liposomal
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0029 OUTCOME OF THE TREATMENT OF AD
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drug-induced apoptotic response of
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41% in the PI3K- group (p=0.001). I
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Acute myeloid leukemia - Clinical I
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to 60 years (n=116, or 72%) receive
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0056 PROGNOSTIC SIGNIFICANCE OF FLT
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Anemia and Bone marrow failure 0061
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tified with the current protocol. S
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new cases of lead poisoning due to
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icance, from baseline to week 6 (p
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0086 THROMBELASTOGRAPHIC CHART RELI
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trials. The aim of this retrospecti
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tant function in this disease, nega
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ed to a favorable outcome. Bialleli
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stronger levels of p21 in the cell
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hematological centers in one countr
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ure 1). Conclusions. Results for re
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patients. After a median follow-up
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Cytogenetics and Molecular diagnost
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0135 ROUTINE DETECTION OF CYTOGENET
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(MMolR, defined as a BCR-ABL x 100
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0146 ARSENIC TRIOXIDE INDUCES ACCUM
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tinguish between genotypic B-cell l
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Genomics and proteomics 0158 PLASMA
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0164 EVALUATION OF MULTIPLEX LIGATI
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each patient’s replicate conditio
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0174 RELATION BETWEEN LOW PML-RARα
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0179 ESHAP VS GIN AS SALVAGE AND MO
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Immunology and gene therapy 0184 EA
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Cell viability was not affected by
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month is not relevant to chronic Gv
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Infection and supportive care I 020
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0206 POTENTIAL ROLE OF CMV IN THE O
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3H-thymidine uptake in cell culture
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0217 TUBERCULOSIS AMONG A COHORT OF
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0222 COMPARISON OF IWG 2006 AND IWG
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tem (IPSS) to h-MDS was also invest
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PCH97-19) were studied. Conventiona
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of erythroid colonies was reduced i
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0245 POTENT AND SELECTIVE INHIBITIO
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0250 INACTIVATION OF SUPPRESSOR OF
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Bortezomib 1.3 mg/m 2 days 1,4,8,11
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Response was defined according to E
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G-CSF can be used in neutropenic pa
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ence and functional activity of CD8
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itating tumor development, or engag
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phoma and SNT-13, -15 were establis
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usage (2/20 ie 10%) were observed.
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0294 MYCOSIS FUNGOIDES. IMMUNOHYSTO
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(range, 1-6) and 11 treatment cycle
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0306 RISK-ADAPTED IMMUNOCHEMOTHERAP
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functional activity was confirmed b
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No major toxicity, neither hematolo
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enewal potential of X-RAR-positive
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(50-99) respectively. Serial analys
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cell-interaction, adhesion and acti
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0340 ALTERED FIBRIN CLOT STRUCTURE
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Conclusions. This study demonstrate
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0354 FACTOR V LEIDEN HOMOZYGOUS GEN
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Results. From July 2005 through Mar
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0364 CLINICAL EFFICACY OF OXALIPLAT
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one marrow and peripheral blood ste
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ecently suggested (Boissel et al.,
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0378 SAFETY AND EFFICACY OF THE TER
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Cytogenetics and molecular diagnost
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0385 CYTOPLASMIC MUTATED NUCLEOPHOS
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0390 ELTROMBOPAG RAISES PLATELET CO
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factor for the achievement of CR wa
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The cases of RAS showed two peaks o
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is 85%. Seven out of the 25 relapse
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0409 FRACTIONATED RADIOIMMUNOTHERAP
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0414 COMPARATIVE ANALYSIS OF THE CO
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successfully managed with GM-CSF di
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49% for PCR positive patients (95%
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+8 (1 PR+1 HI) and 14/24 pts with c
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(e.g. bcr-abl leading to CML). CSC
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0438 TERC MUTATIONS ANALYSIS IN PAT
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observed in all mice. Analysis of l
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ex-vivo expansion of HUCB-derived H
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ic kidney disease in univariate or
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One hundred eleven CN AML patients,
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to asses intestinal epithelial dama
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genesis of acute myeloid leukaemia
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polymorphism at nucleotide 4889 of
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expression along with a decreased C
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0487 MUTATIONAL STATUS OF NUCLEOPHO
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previously reported, a single cours
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0497 SINGLE AGENT CLORETAZINE (VNP4
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ly received melphalan-based chemoth
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were similar among the 3 groups. Ho
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Methods. Several read-out systems w
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0518 SERUM AND CELLULAR EXPRESSION
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0523 DNA REPAIR INHIBITION IN RESTO
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held true when BMI-1 expression was
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Ph + cells in the bone marrow). We
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derivative chromosome (4p16, 7p14,
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0545 STABILIZED BONE MARROW IS NOT
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obtained in low (Sokal) risk patien
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median dose intensity being 800 (21
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from pivotal clinical trials. Metho
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Cytogenetics and Molecular diagnost
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to set up and optimize a D-HPLC-bas
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0576 WESTERN BLOT IDENTIFICATION OF
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Basic disease was AML (n=5), ALL (n
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0588 EXTRACORPOREAL PHOTOPHORESIS F
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acquire a cytolytic capacity agains
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informed vignettes describing healt
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using CHOP-21 in the UK, pegfilgras
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0609 SOFT TISSUE COMPLICATIONS IN P
Page 237 and 238: inding lectin (MBL) gene by polymer
Page 239 and 240: all infection rate (p=0.12) as well
Page 241 and 242: Myelodysplastic syndromes II 0623 M
Page 243 and 244: formation (in total 28 samples). Ti
Page 245 and 246: sion. In addition, confocal analysi
Page 247 and 248: Myeloproliferative disorders - Clin
Page 249 and 250: open-label, multi-centre study enro
Page 251 and 252: iopsies after 6 and 12 months treat
Page 253 and 254: Myeloproliferative disorders Chroni
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Page 257 and 258: induced significant apoptosis (mean
Page 259 and 260: Myeloma and other monoclonal gammop
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Page 263 and 264: er patient does not indicate such t
Page 265 and 266: Myeloma and other monoclonal gammop
Page 267 and 268: secutive patients with MM, referred
Page 269 and 270: whether gene expression values may
Page 271 and 272: 0705 THE SHIFT OF TREATMENT FOR NAS
Page 273 and 274: 0710 CLINICO-PATHOLOGICAL FEATURES,
Page 275 and 276: patients presented a stage IV disea
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Page 279 and 280: known at NHL diagnosis, were includ
Page 281 and 282: 0731 THE IMPACT OF HIV ON NON-HODGK
Page 283 and 284: patients had died of their underlyi
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Page 287: modulated after 24 h (37 up- and 59
Page 291 and 292: and treatment, has rarely been syst
Page 293 and 294: uncontrolled massive bleeding affec
Page 295 and 296: Results. A total of 396 patients we
Page 297 and 298: C30 questionnaire, and the correspo
Page 299 and 300: wave length of light of reflected r
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Page 305 and 306: 0794 CARDIAC MANIFESTATIONS IN A BR
Page 307 and 308: 0799 INEFFECTIVE ERYTHROPOIESIS IN
Page 309 and 310: p=0.014 and p=0.003, respectively).
Page 311 and 312: 0809 CURRENT APPROACH TO CHELATION
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Page 315 and 316: the 97.5th percentile (5.2 U/mL) ge
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Page 319 and 320: Transfusion medicine and vascular b
Page 321 and 322: tions (most bacterial, 2 malaria, 6
Page 323 and 324: 0844 INCREASED LEUKOCYTE-PLATELET I
Page 325 and 326: 0851 CORD BLOOD DERIVED MESENCHYMAL
Page 327 and 328: SIMULTANEOUS SESSION II Chronic mye
Page 329 and 330: 0862 COMPARISON OF DASATINIB TO HIG
Page 331 and 332: 0867 COMPREHENSIVE GERIATRIC ASSESS
Page 333 and 334: 0872 MN1 INDUCES LEUKEMIA IN MICE A
Page 335 and 336: 0877 PAX5/TEL TRANSDUCED PRE-BI CEL
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have an early manifestation of typi
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0892 INTEGRATION OF GENOME WIDE SNP
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0897 THE PHENOTYPE OF JAK2V617F MUT
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gest diverse sequences of NPM mutan
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2004 to January, 2006. At enrollmen
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with a p value of ≥ 0.10. Sets of
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BRIC 126 and 4N1K) in cells lacking
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sclerosis[NS] and 12 Mixed cellular
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0927 MK-0457, A NOVEL MULTIKINASE I
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Publication Only 0933 CLINICAL FEAT
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HSCT from the available Asian as we
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that the incidence of JAK2 mutation
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without type 2 diabetes. Methods. T
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pts (38.8%) that were isolated (abs
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y using the Miltenyi CD34 isolation
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0969 COMPARISON OF CD25 IMMUNOHISTO
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cytes was 24 days (range 8-32 days)
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a cytogenetic hallmark for M4/M5 su
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normal human BM B progenitor cells
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0994 INCIDENCE OF INVASIVE ASPERGIL
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3 of disease relapse.TRM at day+100
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survival of five years. This dismal
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1011 FLOW CYTOMETRIC DNA INDEX AND
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1018 THE EFFECT OF THE SUGARBAKER P
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1024 KIR/HLA CLASS I MISMATCHING AN
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ment details and thrombotic histori
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1036 INCIDENCE AND SPECTRUM OF INFE
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tinely by our stem cell lab prior t
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tion to a translocation t(5;14)(q35
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ment of CML and induces a high rate
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due to reactivation and/or progress
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1063 ABNORMAL METHYLATION STATUS OF
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1069 CLINICAL RELEVANCE OF REGULATO
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1076 SERUM LEVELS OF SOLUBLE HLA CL
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patient is still undergoing intensi
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nificant MVD differences were detec
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dictor of OS (p=0.004). High dose t
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1099 ALTERATIONS IN THE NATURAL KIL
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1105 CYTOGENETIC ABNORMALITIES IN 3
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1110 CONSTITUTIVE ACTIVATION OF STA
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efficacy results with a well-tolera
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unmutated VH genes, and high and lo
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Aims. Aim of this study was to pred
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tested across a wide range of human
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were incidentally diagnosed (52%).
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ß2GP1 may be considered as determi
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characterized in 198 β thalassaemi
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1155 PLATELET AGGREGATION IN CHILDR
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to-pelvic or perineal trauma. No me
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in age. High prevalence of LBM amon
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ecause some of the patients were or
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of the drug is crucial to allow lon
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egarding cost analysis of ASCT in G
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ID Allo-BMT, 1 family one mismatche
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admitted to ICU were discharged des
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events -Postoperative states: 9,19%
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efficacy and decreased atherosclero
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1217 INCIDENCE OF EARLY STAGE IDIOP
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1691GA and 1 homozygous 1691AA. The
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1230 ASSOCIATION OF HEPARANASE GENE
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posed, was: DF = (CD43%+FMC7%+CD79b
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treatment of acute promyelocityc le
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loaded group and 35 (70%) were non-
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mild. Fas and soluble Fas ligand le
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1265 POSACONAZOLE THERAPY IN REFRAC
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ly express the cytoplasmic (inactiv
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findings confirmed the significant
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a less favorable prognosis. Interes
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disease (HD), 4 patients (9%) with
Page 477 and 478:
1295 HEMOPHAGOCYTIC LYMPHOHYSTIOCYT
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phamide 750 mg/m 2 on day 1, vincri
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nomenon is unclear. It has been sug
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oped mild thrombocytopenia (platele
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gle dose of 54mg/m 2 rituximab furt
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patients (pts), 36 male, with acute
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esulting alterations of the endothe
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(range 1-7) and 28,6% of patients h
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three decades. In vivo, Ara-C is tr
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statistical analysis. Results. Seve
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Results. Though there was no recogn
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2% and 19% of patients with or with
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were older than 65 y) which can be
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1376 RESVERATROL INDUCED P53 MEDIAT
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median time of 21 days to reach >0.
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ly. Conclusions. 1. Combined intens
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to the presence of IVS1-6 mutation
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fy predictive factors for these abn
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acute leukemia. However, we cannot
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agents. They involve primarily the
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voriconazole for 2 months followed
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typed using a commercially availabl
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low up of ABL KD mutations’ level
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with development of BC/AP. 2. EVI-1
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1447 THE IMPACT OF DISPARITY IN SHO
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three had visual field defects, two
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acquired mutation most prone to cau
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1466 ROS GENERATION AND APOPTOSIS I
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1473 DIARRHEIC SYNDROME, A CLINICAL
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gene fusion is an independent progn
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1484 EPIDEMIOLOGY AND RESPONSE TO T
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1492 FREQUENCY OF MEDITERRANEAN GLU
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immune globulin was administered at
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maintained on Imatinib 400 mg. Afte
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Hodgkin’s disease is well known,
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gram provided a unique chance to de
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even when ADP-induced plt activatio
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medullary involvement of multiple m
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1540 ADMINISTRATION OF G-CSF AND CH
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1548 QUALITY ANALYSIS OF THE MULTID
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Index of authors A Aapro, M., 0377,
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Bahr, J., 0148 Bai, M., 1551 Baia,
Page 561 and 562:
Bottini, P.V., 1181 Botto, B., 0408
Page 563 and 564:
Chaidos, A., 0456, 0498, 0599, 0686
Page 565 and 566:
De Keersmaecker, K., 0442, 0875 De
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El-Sharkawy, N., 0016 Elwahidi, G.,
Page 569 and 570:
Garcia-Frade, J., 0346, 0680, 1105
Page 571 and 572:
H Haas, N., 0742 Haas, O.A., 0001,
Page 573 and 574:
Jaksic, B., 0127, 0446 Jaksic, O.,
Page 575 and 576:
Körmöczi, G., 0848 Kornblau, S.,
Page 577 and 578:
Lin, L.-I., 0030, 0484 Lin, T., 012
Page 579 and 580:
Massé, A., 0249 Massó, P., 1287,
Page 581 and 582:
Musto, P., 0254, 0401, 0422, 0569,
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Papadavid, E., 1442 Papageorgiou, E
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Probatova, N., 0704 Prochazka, V.,
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Rykavicin, O., 0504 Ryningen, A., 0
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Sirard, C., 0127, 0128 Sirigou, A.,
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Thiebaut, A., 0454 Thieblemont, C.,
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Vincenzi, C., 1060 Viniou, N.-A., 0
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Zouabi, H., 0503, 0999 Zoumbos, N.C
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12th Congress of the European Hematology ... - Haematologica

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