12th Congress of the European Hematology ... - Haematologica

1018
THE EFFECT OF THE SUGARBAKER PROCEDURE ON HAEMOSTASIS
K. Leversuch, 1 J. Needham, 1 A. Roy, 1 A. Milne, 1 G. Knight 2
1 North Hampshire Hospital, BASINGSTOKE, United Kingdom; 2 University of
Portsmouth, PORTSMOUTH, United Kingdom
Pseudomyxoma peritonei is a progressive disease of the peritoneum,
characterised by the gradual accumulation of mucinous fluid in the peritoneum.
Left untreated it is ultimately fatal. Although no cure exists,
the Sugarbaker procedure combining complete cytoreduction, intraoperative
hyperthermic intra-peritoneal chemotherapy and post-operative
intra-peritoneal chemotherapy, has shown promising results. The
aim of this study was to assess haemostatic function in this group of
patients pre-operatively and the effect of the Sugarbaker procedure on
haemostasis. Citrated plasma was collected from 40 patients, pre and
post operatively, and pre and 30 minutes post any blood components
during surgery. Coagulation screening tests and whole blood global assay
for haemostasis were performed. The prothrombin time (PT), activated
partial thromboplastin time (APTT), fibrinogen (Fib) were performed on
the MDA II (Trinity Bioscience). Thromboelastometry tests (Ex-TEM, In-
TEM and Fib-TEM) were performed on the ROTEM (Biodis). Pre-operatively
patients had normal PT (mean = 13.5s) and APTT (mean = 30.6s)
and raised Fib (mean = 4.7g/L), suggesting the possibility of a hypercoagulable
state. The PT (mean pre-op=13.5s, post-op= 15.9s), APTT (mean
pre-op= 30.7s post-op= 36.6s), and fibrinogen (mean pre-op= 4.7g/L postop=
1.6g/L) all displayed significant differences with p values of