12th Congress of the European Hematology ... - Haematologica

1484
EPIDEMIOLOGY AND RESPONSE TO TREATEMENT IN CHILD ACUTE LYMPHOBLASTIC
LEUKEMIA TREATED BY EORTC 58951
M. Bedoui
University hospital of Tunis, TUNIS, Tunisia
Introduction. Child T cell acute lymphocytic leukaemia has been shown
by many studies to have an unfavorable prognosis. But there is a significant
improvement in outcome for patients with T-ALL due to the use
of intensive rotating pulses of chemotherapy. Materials and methods.
Between January 2001 and Decembery 2005,120 children with ALL have
been treated in our institution (university hospital of Tunis).We reviewed
only those with T ALL. 41 patients with T-ALL were treated by pediatric
protocol 58951 of EORTC. Results. Median age of children was 9.5 years
(Quartiles 2 years-20 years). In 14 patients (34%) the age was ″ 10 years.
RS: 2.15 (28 boys and 13 girls). Tumoral syndrom was observed in 37 cases
(90%). One case of nervous system disease with a facial paralesy.
Median presenting WBC was 156000/ mm3 (quartiles 2600- 760000);
WBC ≥50000/mm3 was noted In 28 patients (68 ), in 25 WBC≥
100000/mm3 . karyotyp was normal in 56% of patients. Immunophenotypic
presentation: 18 immature T , 12 cortical T, 9 pré T and 2 mature
T. Response to treatement at day 8 of induction: age