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12 th Congress of the European Hematology Association III by international staging system (ISS). PET/CT was performed at initial diagnosis and 7th day after 1st chemotherapy (D7), respectively. The number of hypermetabolic lesion (HML), maximum SUV and functional volume of HML with cut off value of SUV of 2.5 were measured and the changes between 2 time points of PET were evaluated. The responses of PET/CT were classified as complete response (CR, >95% reduction for the individual parameters), partial response (PR, >50% reduction), minimal change (MC, 25% of aggravation). The responses on PET/CT were compared with clinical responses based performance status and laboratory findings. For the clinical responses, 7 patients were assessed at the end of complete chemotherapy cycles (5.6±2.4 cycles) and 2 patients at the time after 2nd cycle of chemotherapy. Results. The therapeutic responses of MM patients were CR of 3, PR of 3, MC of 1, and PD of 2 patients by clinical response assessments according to EBMT criteria and CR of 2, PR of 5, MC of 1, and PD of 1 patient by D7 PET/CT. The changes for the maximum SUV and functional volume of HML had a good correlation with clinical response (rho=0.695, and rho=0.782, p
(range 1-7) and 28,6% of patients had undergone prior autotransplant. Results. The response was evaluated according to the EBMT criteria in 48 patients ( 85,7%) with a media of 6cycles completed of treatment ( 1-16). The evaluation at 4º cycle was: complete response (CR):8,33%; near complete response (CnR): 20,83%; partial response (PR): 33,3%; minimal response (MR): 10,4%; stable disease (SD): 6,25%; progression: 14,58%. At the end of the treatment (with a media of 6 cycles) 35 patients had been evaluated (62,5%); obtaining the following responses: CR:28,57%; CnR: 14,28%; PR: 14,28%; MR: 8,57%; progression: 8,57%. Overall survival 83,92%. Toxicity profile WHO grade 3-4: thrombocytopenia: 19.6%; neuropathy 12,5%; gastrointestinal: 5,3%; zoster herpex virus infection:14%. In 48% of patients a dose reduction was required. Conclusion. Bortezomib is an effective agent with acceptable toxicity for the treatment of patients with relapsed/ refractory MM. The response rates, overall survival and toxicity in our series is similar to data described in previous studies although a longer follow up is needed in order to confirm these results. 1341 PROGNOSTIC FACTORS OF ANTITHYMOCYTE GLOBULIN FOR APLASTIC ANEMIA A. Mori, 1 N. Toyoshima, 1 M. Saito, 1 T. Irie, 1 M. Asaka, 2 M. Imamura, 2 M. Morioka1 1 2 Aiiku Hospital, SAPPORO, Japan; Hokkaido University Graduate School of M, SAPPORO, Japan Background. Immunosuppressive treatment with a combination of antithymocyte globulin (ATG) and cyclosporine (CsA) is the most effective treatment for patients with aplastic anemia (AA). Further, it is suitable for patients of advanced age. Several prospective randomized studies have been reported, however, definite prognostic factor associated with response rate has not been cleared. Aims. To assess long-term outcomes after immunosuppressive treatment, and analyze the potent prognostic factors. Methods. We retrospectively evaluated 24 ATG with CsA treatments (ATG treatments) which include re-treatment of ATG in patients who had not responded to the first ATG treatment or relapsed after the first remission. Results. The median age was 66 years, and the median follow-up period was 52 months. The response and relapse rate of ATG treatment were 70.8% and 23.1%, respectively. The response rate of ATG re-treatment was 57.1%. Overall survival and event free survival at 10 years were 66.7% and 50.7%, respectively. Initial reticulocyte count correlated with the response rate of ATG treatment (responders v.s. non-responders = 23331±14201 (±SD) /mm 3 v.s. 8856±4885 /mm 3 , p=0.045). Further, the longer duration from diagnosis to ATG treatment (responders v.s. non-responders = 0.615±0.18 v.s. 8.50±4.98 months, p=0.0077) and male correlated with the poor response rate independently. On the other hand, patient age, initial platelet count, initial granulocyte count, initial nuclear cell count of bone marrow, total dose of ATG, and co-administration of granulocyte colony-stimulating factor did not significant influence response rate. Although almost all ATG treatments were tolerable, as the long-term complication, two developed monosomy 7 clonal abnormality. Conclusions. These results suggest that ATG treatment can achieve a high response rate and long-term survival among adult patients with AA. Initial reticulocyte count, the duration from diagnosis to ATG treatment, and sex could be the potent prognostic factors with ATG treatment. However, we have to pay attention to the development of the clonal diseases. Figure 1. 12 th Congress of the European Hematology Association 1342 THE ANTILEUKEMIC ACTIVITY OF THALIDOMIDE (THAL) IN COMBINATION WITH FLUDARABINE (F) IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA M. Kowal, A. Dmoszynska, K. Giannopoulos, P. Wlasiuk, A. Bojarska- Junak, T. Gromek, M. Podhorecka, E. Wasik-Szczepanek, J. Rolinski Medical University Lublin, LUBLIN, Poland Background. Thalidomide (THAL) is an immunomodulatory agent with pleiotropic activities. It may enhanced proapoptic activity of fludarabine (F) with the resultant improvement of clinical responses. We report the interim findings of the efficacy and safety of THAL+F combined therapy in B-CLL patients. Methods. 31 patients (pts) were enrolled in this study. The median age was 62 yrs (range 43-75). 14 of them (10M, 4F) were newly diagnosed and 17 (7M, 10F) pts were refractory or relapsed. Of these 3 had low risk, 20 pts intermediate risk, 8 pts high risk disease acc to modified Rai staging, 71% of pts had elevated serum β-2 microglobulin. The increased Zap70 and/or CD38 expression had 64% and/or 28% of pts respectively. 16 pts (55%) had short LDT < 6 months. 5 pts were refractory to F, 6 pts to alkylating agents and 6 pts were relapsed. Median prior lines of therapy were 3, range 1-6. THAL 100 mg po, alone was given for the first 7 days of cycle 1 and continued a la longue for 6 months, F 25 mg/m2 iv or 40 mg/m2 po, was given for 5 days every 28 days for up to 6 cycles, starting on the seventh day after initiating THAL. Acetylsalicylic acid 75 mg was used for preventation of venous thromboembolism. Results. Median duration of follow-up was 6months (range 1-14). Pts completed 1- 6 cycles, mean 5. Monotherapy of THAL decreased mean 30% (range 3-57) of white blood cells (WBC) in 26 pts. Directly after 1 cycle of therapy 31 pts showed subsequent reduction in WBC. 22 pts have received treatment for at least 3 months and are therefore evaluable for clinical response acc to NCI-WG criteria. Overall response rate among evaluable pts was 91% with CR in 18% (n=4) and PR in 72% (n=16) of the pts. 2 heavily pretreated pts attained stable disease after 2 cycles but therapy was stopped due to toxicity. 8 pts finshed treatment. The median duration of progression-free survival was 4 months (range1-7). 4 pts were inevaluable (unable to complete 2 treatment cycles; either for toxicity or progression), 5 pts are too early for response evaluation. Toxicity: All 31 pts are evaluable for toxicity. Constipation and fatigue were noted in nearly all pts. A tumor flare reaction developed in 23% of pts during the first week of treatment with THAL. Infections occured in 52% of pts, severe > G3 were observed in 4 pts. The main hematological toxicites were > G3 neutropenia (26%) and AIHA (13%). Correlative studies: Levels of TNF-α and IL-10 were assessed D0, D7 and D12. T regulatory cells were identified as CD4 + CD25highFOXP3 + . This data will be presented at the meeting. Conclusions. Monotherapy of THAL and in combination with F is active not only as a first line therapy but also as a treatment in heavily pretreated pts with B-CLL, with tolerable toxicity. These results warrant further investigation of larger group of pts . 1343 PALPEBRAL OEDEMA REVEALING ORBITAL INTRAMUSCULAR OEDEMA AND ADIPOUS PALPEBRAL INFILTRATION IN CML PATIENTS TREATED WITH IMATINIB MESYLATE Ph. Rousselot, 1 P. Rousselot, 1 D. Réa, 2 J.P. Beressi, 1 F. Calvo, 2 V. Levy, 2 H. Bruzzoni, 2 M.T. Ibazizen, 3 L. Jablon3 1 Hôpital de Versailles, LE CHESNAY, France; 2 Hôpital Saint-Louis, PARIS, France; 3 Hôpital des Quinze-Vingts, PARIS, France Background. Imatinib Mesylate is now the first line therapy for patients (pts) with chronic phase chronic myelogenous leukaemia (CP CML). In most pts side effects are moderate to mild and easily corrected by appropriate medications. Fluid retention and oedema are common and occur in 50% of patients. In most cases, diuretics are efficient. Periorbital oedema is the most frequent manifestation of fluid retention and appears to be dose related. We report 4 cases of palpebral oedema with additional ophtalmological signs such as retraction of the upper lid and slight exophtalmia. Patients and Methods. CP CML pts treated with imatinib 300 to 600 mg per day at Saint-Louis hospital were included in the study if they presented major periorbital oedema or oedema with additional ophtalmological manifestations. Patients were then referred to the ophthalmologist for clinical evaluation. MRI was proposed to all patients at the National Ophtalmological Center, Hôpital des Quinze-Vingts. Results. Four pts out of 120 were explored. They received imatinib at the dose of 300 to 600 mg per day during a median of 31 months. Oedemas were noted after 12 months of therapy (1-19 months) and were associated with generalized oedema and weight gain in 2 cases. Patients with generalized oedema developed the palpebral complication earlier compare haematologica/the hematology journal | 2007; 92(s1) | 483
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haematologica the hematology journa
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Information for readers, authors an
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EHA Executive Board E. Hellström-L
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Poster session I POSTER SESSION POS
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12 th Congress of the European Hema
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dasatinib. Methods. We studied Ikar
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Expression of the oncogene H-Ras an
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is the gene for the erythropoietin
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safety of a slow-release liposomal
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0029 OUTCOME OF THE TREATMENT OF AD
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drug-induced apoptotic response of
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41% in the PI3K- group (p=0.001). I
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Acute myeloid leukemia - Clinical I
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to 60 years (n=116, or 72%) receive
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0056 PROGNOSTIC SIGNIFICANCE OF FLT
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Anemia and Bone marrow failure 0061
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tified with the current protocol. S
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new cases of lead poisoning due to
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icance, from baseline to week 6 (p
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0086 THROMBELASTOGRAPHIC CHART RELI
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trials. The aim of this retrospecti
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tant function in this disease, nega
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ed to a favorable outcome. Bialleli
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stronger levels of p21 in the cell
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hematological centers in one countr
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ure 1). Conclusions. Results for re
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patients. After a median follow-up
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Cytogenetics and Molecular diagnost
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0135 ROUTINE DETECTION OF CYTOGENET
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(MMolR, defined as a BCR-ABL x 100
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0146 ARSENIC TRIOXIDE INDUCES ACCUM
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tinguish between genotypic B-cell l
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Genomics and proteomics 0158 PLASMA
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0164 EVALUATION OF MULTIPLEX LIGATI
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each patient’s replicate conditio
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0174 RELATION BETWEEN LOW PML-RARα
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0179 ESHAP VS GIN AS SALVAGE AND MO
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Immunology and gene therapy 0184 EA
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Cell viability was not affected by
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month is not relevant to chronic Gv
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Infection and supportive care I 020
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0206 POTENTIAL ROLE OF CMV IN THE O
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3H-thymidine uptake in cell culture
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0217 TUBERCULOSIS AMONG A COHORT OF
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0222 COMPARISON OF IWG 2006 AND IWG
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tem (IPSS) to h-MDS was also invest
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PCH97-19) were studied. Conventiona
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of erythroid colonies was reduced i
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0245 POTENT AND SELECTIVE INHIBITIO
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0250 INACTIVATION OF SUPPRESSOR OF
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Bortezomib 1.3 mg/m 2 days 1,4,8,11
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Response was defined according to E
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G-CSF can be used in neutropenic pa
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ence and functional activity of CD8
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itating tumor development, or engag
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phoma and SNT-13, -15 were establis
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usage (2/20 ie 10%) were observed.
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0294 MYCOSIS FUNGOIDES. IMMUNOHYSTO
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(range, 1-6) and 11 treatment cycle
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0306 RISK-ADAPTED IMMUNOCHEMOTHERAP
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functional activity was confirmed b
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No major toxicity, neither hematolo
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enewal potential of X-RAR-positive
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(50-99) respectively. Serial analys
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cell-interaction, adhesion and acti
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0340 ALTERED FIBRIN CLOT STRUCTURE
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Conclusions. This study demonstrate
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0354 FACTOR V LEIDEN HOMOZYGOUS GEN
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Results. From July 2005 through Mar
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0364 CLINICAL EFFICACY OF OXALIPLAT
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one marrow and peripheral blood ste
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ecently suggested (Boissel et al.,
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0378 SAFETY AND EFFICACY OF THE TER
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Cytogenetics and molecular diagnost
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0385 CYTOPLASMIC MUTATED NUCLEOPHOS
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0390 ELTROMBOPAG RAISES PLATELET CO
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factor for the achievement of CR wa
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The cases of RAS showed two peaks o
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is 85%. Seven out of the 25 relapse
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0409 FRACTIONATED RADIOIMMUNOTHERAP
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0414 COMPARATIVE ANALYSIS OF THE CO
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successfully managed with GM-CSF di
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49% for PCR positive patients (95%
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+8 (1 PR+1 HI) and 14/24 pts with c
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(e.g. bcr-abl leading to CML). CSC
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0438 TERC MUTATIONS ANALYSIS IN PAT
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observed in all mice. Analysis of l
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ex-vivo expansion of HUCB-derived H
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ic kidney disease in univariate or
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One hundred eleven CN AML patients,
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to asses intestinal epithelial dama
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genesis of acute myeloid leukaemia
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polymorphism at nucleotide 4889 of
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expression along with a decreased C
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0487 MUTATIONAL STATUS OF NUCLEOPHO
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previously reported, a single cours
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0497 SINGLE AGENT CLORETAZINE (VNP4
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ly received melphalan-based chemoth
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were similar among the 3 groups. Ho
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Methods. Several read-out systems w
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0518 SERUM AND CELLULAR EXPRESSION
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0523 DNA REPAIR INHIBITION IN RESTO
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held true when BMI-1 expression was
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Ph + cells in the bone marrow). We
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derivative chromosome (4p16, 7p14,
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0545 STABILIZED BONE MARROW IS NOT
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obtained in low (Sokal) risk patien
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median dose intensity being 800 (21
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from pivotal clinical trials. Metho
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Cytogenetics and Molecular diagnost
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to set up and optimize a D-HPLC-bas
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0576 WESTERN BLOT IDENTIFICATION OF
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Basic disease was AML (n=5), ALL (n
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0588 EXTRACORPOREAL PHOTOPHORESIS F
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acquire a cytolytic capacity agains
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informed vignettes describing healt
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using CHOP-21 in the UK, pegfilgras
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0609 SOFT TISSUE COMPLICATIONS IN P
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inding lectin (MBL) gene by polymer
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all infection rate (p=0.12) as well
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Myelodysplastic syndromes II 0623 M
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formation (in total 28 samples). Ti
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sion. In addition, confocal analysi
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Myeloproliferative disorders - Clin
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open-label, multi-centre study enro
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iopsies after 6 and 12 months treat
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Myeloproliferative disorders Chroni
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ash, muscolar cramps, diarrhoea, he
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induced significant apoptosis (mean
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Myeloma and other monoclonal gammop
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the therapy of choice for POEMS is
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er patient does not indicate such t
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Myeloma and other monoclonal gammop
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secutive patients with MM, referred
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whether gene expression values may
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0705 THE SHIFT OF TREATMENT FOR NAS
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0710 CLINICO-PATHOLOGICAL FEATURES,
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patients presented a stage IV disea
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plete remission or recurrent diseas
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known at NHL diagnosis, were includ
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0731 THE IMPACT OF HIV ON NON-HODGK
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patients had died of their underlyi
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scripts and proteins most affected
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modulated after 24 h (37 up- and 59
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0753 A SUSTAINED REMISSION OF IDIOP
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and treatment, has rarely been syst
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uncontrolled massive bleeding affec
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Results. A total of 396 patients we
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C30 questionnaire, and the correspo
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wave length of light of reflected r
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0783 PREVALENCE OF MEMBRANE PROTEIN
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erozygous mother has a more severe
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0794 CARDIAC MANIFESTATIONS IN A BR
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0799 INEFFECTIVE ERYTHROPOIESIS IN
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p=0.014 and p=0.003, respectively).
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0809 CURRENT APPROACH TO CHELATION
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Thrombosis II 0814 UNSUSPECTED PULM
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the 97.5th percentile (5.2 U/mL) ge
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symptoms of DVT, 3 (7.89%) previous
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Transfusion medicine and vascular b
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tions (most bacterial, 2 malaria, 6
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0844 INCREASED LEUKOCYTE-PLATELET I
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0851 CORD BLOOD DERIVED MESENCHYMAL
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SIMULTANEOUS SESSION II Chronic mye
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0862 COMPARISON OF DASATINIB TO HIG
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0867 COMPREHENSIVE GERIATRIC ASSESS
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0872 MN1 INDUCES LEUKEMIA IN MICE A
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0877 PAX5/TEL TRANSDUCED PRE-BI CEL
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0882 CISPLATIN INDUCES THROMBIN GEN
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have an early manifestation of typi
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0892 INTEGRATION OF GENOME WIDE SNP
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0897 THE PHENOTYPE OF JAK2V617F MUT
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gest diverse sequences of NPM mutan
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2004 to January, 2006. At enrollmen
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with a p value of ≥ 0.10. Sets of
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BRIC 126 and 4N1K) in cells lacking
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sclerosis[NS] and 12 Mixed cellular
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0927 MK-0457, A NOVEL MULTIKINASE I
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Publication Only 0933 CLINICAL FEAT
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HSCT from the available Asian as we
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that the incidence of JAK2 mutation
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without type 2 diabetes. Methods. T
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pts (38.8%) that were isolated (abs
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y using the Miltenyi CD34 isolation
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0969 COMPARISON OF CD25 IMMUNOHISTO
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cytes was 24 days (range 8-32 days)
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a cytogenetic hallmark for M4/M5 su
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normal human BM B progenitor cells
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0994 INCIDENCE OF INVASIVE ASPERGIL
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3 of disease relapse.TRM at day+100
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survival of five years. This dismal
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1011 FLOW CYTOMETRIC DNA INDEX AND
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1018 THE EFFECT OF THE SUGARBAKER P
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1024 KIR/HLA CLASS I MISMATCHING AN
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ment details and thrombotic histori
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1036 INCIDENCE AND SPECTRUM OF INFE
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tinely by our stem cell lab prior t
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tion to a translocation t(5;14)(q35
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ment of CML and induces a high rate
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due to reactivation and/or progress
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1063 ABNORMAL METHYLATION STATUS OF
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1069 CLINICAL RELEVANCE OF REGULATO
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1076 SERUM LEVELS OF SOLUBLE HLA CL
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patient is still undergoing intensi
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nificant MVD differences were detec
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dictor of OS (p=0.004). High dose t
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1099 ALTERATIONS IN THE NATURAL KIL
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1105 CYTOGENETIC ABNORMALITIES IN 3
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1110 CONSTITUTIVE ACTIVATION OF STA
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efficacy results with a well-tolera
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unmutated VH genes, and high and lo
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Aims. Aim of this study was to pred
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tested across a wide range of human
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were incidentally diagnosed (52%).
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ß2GP1 may be considered as determi
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characterized in 198 β thalassaemi
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1155 PLATELET AGGREGATION IN CHILDR
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to-pelvic or perineal trauma. No me
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in age. High prevalence of LBM amon
Page 439 and 440: ecause some of the patients were or
Page 441 and 442: of the drug is crucial to allow lon
Page 443 and 444: egarding cost analysis of ASCT in G
Page 445 and 446: ID Allo-BMT, 1 family one mismatche
Page 447 and 448: admitted to ICU were discharged des
Page 449 and 450: events -Postoperative states: 9,19%
Page 451 and 452: efficacy and decreased atherosclero
Page 453 and 454: 1217 INCIDENCE OF EARLY STAGE IDIOP
Page 455 and 456: 1691GA and 1 homozygous 1691AA. The
Page 457 and 458: 1230 ASSOCIATION OF HEPARANASE GENE
Page 459 and 460: posed, was: DF = (CD43%+FMC7%+CD79b
Page 461 and 462: treatment of acute promyelocityc le
Page 463 and 464: loaded group and 35 (70%) were non-
Page 465 and 466: mild. Fas and soluble Fas ligand le
Page 467 and 468: 1265 POSACONAZOLE THERAPY IN REFRAC
Page 469 and 470: ly express the cytoplasmic (inactiv
Page 471 and 472: findings confirmed the significant
Page 473 and 474: a less favorable prognosis. Interes
Page 475 and 476: disease (HD), 4 patients (9%) with
Page 477 and 478: 1295 HEMOPHAGOCYTIC LYMPHOHYSTIOCYT
Page 479 and 480: phamide 750 mg/m 2 on day 1, vincri
Page 481 and 482: nomenon is unclear. It has been sug
Page 483 and 484: oped mild thrombocytopenia (platele
Page 485 and 486: gle dose of 54mg/m 2 rituximab furt
Page 487 and 488: patients (pts), 36 male, with acute
Page 489: esulting alterations of the endothe
Page 493 and 494: three decades. In vivo, Ara-C is tr
Page 495 and 496: statistical analysis. Results. Seve
Page 497 and 498: Results. Though there was no recogn
Page 499 and 500: 2% and 19% of patients with or with
Page 501 and 502: were older than 65 y) which can be
Page 503 and 504: 1376 RESVERATROL INDUCED P53 MEDIAT
Page 505 and 506: median time of 21 days to reach >0.
Page 507 and 508: ly. Conclusions. 1. Combined intens
Page 509 and 510: to the presence of IVS1-6 mutation
Page 511 and 512: fy predictive factors for these abn
Page 513 and 514: acute leukemia. However, we cannot
Page 515 and 516: agents. They involve primarily the
Page 517 and 518: voriconazole for 2 months followed
Page 519 and 520: typed using a commercially availabl
Page 521 and 522: low up of ABL KD mutations’ level
Page 523 and 524: with development of BC/AP. 2. EVI-1
Page 525 and 526: 1447 THE IMPACT OF DISPARITY IN SHO
Page 527 and 528: three had visual field defects, two
Page 529 and 530: acquired mutation most prone to cau
Page 531 and 532: 1466 ROS GENERATION AND APOPTOSIS I
Page 533 and 534: 1473 DIARRHEIC SYNDROME, A CLINICAL
Page 535 and 536: gene fusion is an independent progn
Page 537 and 538: 1484 EPIDEMIOLOGY AND RESPONSE TO T
Page 539 and 540: 1492 FREQUENCY OF MEDITERRANEAN GLU
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immune globulin was administered at
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maintained on Imatinib 400 mg. Afte
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Hodgkin’s disease is well known,
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gram provided a unique chance to de
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even when ADP-induced plt activatio
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medullary involvement of multiple m
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1540 ADMINISTRATION OF G-CSF AND CH
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1548 QUALITY ANALYSIS OF THE MULTID
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Index of authors A Aapro, M., 0377,
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Bahr, J., 0148 Bai, M., 1551 Baia,
Page 561 and 562:
Bottini, P.V., 1181 Botto, B., 0408
Page 563 and 564:
Chaidos, A., 0456, 0498, 0599, 0686
Page 565 and 566:
De Keersmaecker, K., 0442, 0875 De
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El-Sharkawy, N., 0016 Elwahidi, G.,
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Garcia-Frade, J., 0346, 0680, 1105
Page 571 and 572:
H Haas, N., 0742 Haas, O.A., 0001,
Page 573 and 574:
Jaksic, B., 0127, 0446 Jaksic, O.,
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Körmöczi, G., 0848 Kornblau, S.,
Page 577 and 578:
Lin, L.-I., 0030, 0484 Lin, T., 012
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Massé, A., 0249 Massó, P., 1287,
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Musto, P., 0254, 0401, 0422, 0569,
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Papadavid, E., 1442 Papageorgiou, E
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Probatova, N., 0704 Prochazka, V.,
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Rykavicin, O., 0504 Ryningen, A., 0
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Sirard, C., 0127, 0128 Sirigou, A.,
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Thiebaut, A., 0454 Thieblemont, C.,
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Vincenzi, C., 1060 Viniou, N.-A., 0
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Zouabi, H., 0503, 0999 Zoumbos, N.C
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12th Congress of the European Hematology ... - Haematologica

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