12th Congress of the European Hematology ... - Haematologica

disease (HD), 4 patients (9%) with acute lymphoblastic leukemia (ALL),
4 patients (9%) with multiple myeloma (MM), 1 patient (2%) with lymphoproliferative
syndrome (LS) and 1 patient (2%) with acute biphenotypic
leukemia (BL). The healthy control group include 43 age-matched
persons (19 females and 24 males). Plasma concentration of L-arginine
and ADMA were measured using high-performance liquid chromatography
(HPLC) and precolumn derivatization with o-phtaldialdehyde
(OPA). For statistical analysys Student’s test was used. p5%, monocytosis >4.109/L and presence of circulating immature
myeloid cells were poor prognostic factors but not abnormal LDH
level, white blood cell count >10.109/L, platelets level