ets exposure, lung cancer - Legacy Tobacco Documents Library

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http://legacy.library.ucsf.edu/tid/wyk81f00/pdf
smoked, Although problems of recall and other poten•
tial biues may have influenced the raults, our data
suggest that exposure in earlv life may be a limited but
important contributor to the nsk of lung cancer in
nonsmoken A previous studN wit}t a smal' number of
subjects found little evidence of an elevated nsk
of lung c.ancer among nonsmokers whose parenu had
smoked " Children of parenu who smoke ha%e been
shoMn to be apeciall% suscepuble to respiratory prob•
lems that occur soon after exposure to environmentaJ
tobacco smoke,s This type of suscepubifiry might
initiate changes that eventually lead to lung cancer
when the exposed children become adulu, but we
know of no specific mechanism that would explain our
findings
We found no adverse e(iecu of exposure to tobacco
smoke in the workplace, althou`h we did not have
enough information about the bevel of expo.ure in
the workplace to auese the precision of our meaiure•
menu . The apparent protective s:fiect of exposure
in sociai aetunp is difficult to explain . During the
course of this study, s,etulations in New York began
to restrict smoking in the workplace and in social set•
tin`s such as rcstauranu . We did not anticipau thiu
development and cannot estimate how much the
awareness of these new ratrictions might have af•
fected the responses of the study subjects or their
surrogates .
Evidence is clearly mounting that tobacco smok .t
inhaled pusively by tsonsmoken is potentially cur•
cinogenic . In a recent study, Madure et al r' found
elcvated levels of cardnojens in the blood of pusive
smokers Levels of hemoglobin adducu of 4-aminobi•
phenyl and adducu of 3-aminobiphenyl were sig-nifi•
cantly elevated in subjecu with confirmed exposurc .
The validiry of this findinj was supponed by addi•
uonal evidence that showed a tharp declir.t in thr
kvels of adducu among smokers who quit'
At prnent, information on put exposure to ent,
ronmental tobacco smoke can be obtatned onh b•
interview . The available biologic marken, such as co
tinine, cannot be used so confirm exposure that ox
curred years or decades earlier . The use o( tntetvse• :
to obtain a lifeume history of exposure to puu