ets exposure, lung cancer - Legacy Tobacco Documents Library

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Second Cancers in Patdents
With Chronic Lymphocytic
Leukemia
LoEs B. Travis,• Rochelle E .
Curtis, Benjamin F. Narthey,
Joseph F. Fraumerti, Jr .
Ieckjroyxd: Reports te dale have
pr.vided widely diverYtat estimatea
sf the risk .f sccond maligaaat .eaplams
la patients with chronic Iysa-
'Mocytic leukemia (CLLI, raatlaj
Ir .m aacer t/eficits to excesses st
twofold to threefold . l+rrpose: Orr
purpose was to ettimate the rlik af
secoad primary eaacers fotiowiag
CLI., t.tlliiiat population-based /r-
•ar retistriet, sad to determi .e
wkether site-specitic excesses might
be ass.ciated with type •r iaitial
lrealsaeat f.r CLL . Methods : We
http://legacy.library.ucsf.edu/tid/wyk81f00/pdf
•satysed date f.r pJSf patieats
di:ra .sed wltt CLL as a first priaaary
rxarer `etweea 1173 aad tlit,
who wcrt rsponed te e ..c of sise tYror
registries participatinj la the
Natioaal Ca .cer Iastiiute's Srrvellls
.ce, Epidemiology, sad Ead
Resrlis (SEERt protrasn aad who
atsrvived 2•r snorr sa .atht . SEEK
filet wert scarched for (avasive pri•
wary .uliGoa .cies that developed at
kast 2 snonths aftcr the t.itial CLL
d[alt.rsis. Nes>rtu : Cwnparsd witM the
te .erai popufatioa, CLL patleats
dcmo .strated a allaificaatly (a•
crsased risk .f developi .g all fer .wd
tancer: (tt10 .trserved ; .Asrrred-Ioexperird
rmllo iU/E) a 1 .2tt ; 1Sr4 watideace
i.terval (CIj s Lif-1 t7l >wikalficsat
excesses were • .ted f.r
e.acen af twe 1r .p (O/E ∎ I .f0) .
brain (O(E . 1 .951 . aMd e,vt (Ialrsrecutar
snetaaom :i (O/E a3171 as well ak
mslitnant melanums (O/E a 2 .79)
a .d fiudptJn'i diuau (O/E a 7A91 .
Cancer riti., which did sol vsry sceording
to t .ltial treatmeal tates.ry,
wat also eoastanl across all time ialcrvals
aRer CLL diag .osis. Ce+aelwsionr
CLL patieats art at a sltaiAantly
Increased risk sf developing a
second maiizaant seoplasm . The pattera
•f cancer excesset suggests a
susceptibility state pertnittinj the tievetopmen(
•f seleclcd record aaatitsancies
In patients with CLL, perhaps
because sf shared etiolo=ic fad .n,
ImmunofoCic impairstte .t, sad/ar
Nher Influences . Althouth .ur res.lu
do sot sut=est a ttront lreat .eat
eRect, srori detailed studies of second
tumors In CU,L are aeeded to lavesli•
&atc lhe role of radiation therapy and
ehemothcrapy• lJ Nati Caatxr /ast
814422-1427, 1ff21
ratients with chronic ly/nphocytie
kukcmia (CLL) cxhihit a variety of imsnunolotic
pcrsurhation>, (1•I) that may
iacreaae ihcir riik for second malignant
aanplasms . 'flM occurrence of f .milial
Ct.t- snay ai>n sug&eu, for some auh-
jeC1A, `enelic determinantR (S•7)- n.ch
as Ihosc that rnderlie other am of aeui-
/iptc primsry eancers (d.4) . Moreover,
radiotherapy and ehemotberapcrrtie
rtenls tnxy also contribute lo tubsc•
"at trutiSnancics awoRE aarel wrvivors
(10) . h)i islpoeunt to e{arify tlc
risk of sccond nactrs iu CLt patienu
kausc of the potc .lial i.r¢tact ar'a .
/ient ma.s=ement, folloMwp . awd sur•
vivat . liowever, various teporu to date
Aave prewided divcr0eat etuirnatai of thc
nccuncncc nf seccmd malipn .ncic> in
CLt, prticnll, esnting frcxn cancer dcfi•
e:itt to cxccar.es of twofold lo ty reefold
To funher expiorc and quantify
thc ri .k of secrnd eaaccrti amnnF a
iarY,: a.snl.cr of CU . patieatk ia lh, :
stnt•~ta) perpulatics. .ad 60 csa/aiac aa>,r .ciatiewst.
af tisk with iaitial IAstaf+~ . ac
ct>t+Juctcd a errvcy cr1' tNCwc tMan WKxt
arrA whjctu. eer.Ntcd k+ th,.• Natinn .t
('anccr (raaitutc' . Survcitlarcc . Epi .
ek:miuitrry . and End llcsult . (SEER)
Prorram' from IV71 thtourh IVK)i .
Siacc CLIL palicals src frcqucatly
trratrd naly evith aakylatinp aFc'at . r•ithewt
ibc ennftwndinp, ctfcn~ . nf rad,.thcrary
. ehi,. =rnup of paticntu ptovidc+
a apcciai opponunity to uud~ tbc latc
acquctac of tflleae rlrup,
Patients asid Methodt
We aaatysed all patients diataosed
with CLlL as a 6rst primary au,eet be•
twexn 1973 and 148b who Wcn reporle,d
10 onc of .Sac populatioo-based ancYr
.ejistries of the SEER Projram aad lrrvi.red
2 a tewre wronths. Sue1 «Yiscrics
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