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ets exposure, lung cancer - Legacy Tobacco Documents Library

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0<br />

i<br />

GENERAL COMMENTS<br />

The same criticisms that apply_to the spousal smoking risk<br />

estimates apply to the workplace risk estimates (no actual<br />

measurements of <strong>exposure</strong>, failure to account for sources of<br />

bias and for potential confounding factors, poor study design,<br />

weak reported associations) .<br />

As illustrated in Table 1, only two of the reported risk<br />

estimates<br />

majority,<br />

significant .<br />

are statistically significant . The overwhelming<br />

16 of 18 risk estimates, are not statistically<br />

Taken as a whole, these data do not support the<br />

existence of an association between workplace <strong>exposure</strong> to ETS<br />

and <strong>lung</strong> <strong>cancer</strong> risk in nonsmokers .<br />

As recently noted by LeVois and Layardl :<br />

The EPA' s<br />

workplaces<br />

therefore<br />

<strong>cancer</strong>, so<br />

fourth point, that ETS <strong>exposure</strong> in<br />

is comparable to home <strong>exposure</strong>, and<br />

if home <strong>exposure</strong> can cause <strong>lung</strong><br />

can workplace <strong>exposure</strong>, is not an<br />

argument for dismissing the workplace<br />

epidemiology at all . Rather, it simply avoids<br />

the question of why, if domestic and workplace<br />

<strong>exposure</strong>s are comparable, the combined<br />

workplace data do not indicate any ETS-<strong>lung</strong><br />

<strong>cancer</strong> association .<br />

1 . LeVois, M .E ., and Layard, M .W ., "Inconsistency Between<br />

Workplace and Spousal Studies of Environmental <strong>Tobacco</strong> Smoke<br />

and Lung Cancer," Regulatory Toxicoloay and Pharmacoloay 19 :<br />

309-316, 1994 .<br />

http://legacy.library.ucsf.edu/tid/wyk81f00/pdf

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