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http://legacy.library.ucsf.edu/tid/wyk81f00/pdf yicld approrimatcly I50 maJe and 230 femaJc ncvcr tmokers, bascd oa cstimatss of tbc fre .quency o! <strong>lung</strong> c.a .nccr amooE nevcr imokcrs (25/,c for malcs asd 105'c fos fcmaJes (7(), 7ablc 7 tbows tbc sa.mplc aizcs aeczuv} in cacb 1proup (assumiag equa .l tumbcrs of cases and e :ontrols) to detcct RRs berwcen 125 and 2 .00, witb a ooc•taiicd aJpba of 5% asd 80% power, pvea various proponions of cxposcd controls . i4'bilc it is hig.Lly unlikcly tDat tucb a uudy would bc fundcd tolely to assru tbc effects o` ETS ezposure, tbc ttudy cotild be de44=" to make am imponant coatnbutioa to t,be radon•luag cunc.cr issuc as .+ell. Spc .dfically, ttud3u of domestic radoa expc>sure luve also tufferc .d from sma!I ssmpfe iuu and boYC produced .wriablc and uastable ulimatet of tbc tisk of radoa c"sure in aevtr tmolcrs . la addiuon, tbere is a oecd to better aucu tbe iateractivs cifcru of aexivs tmokinF and radorr expostue . Sincc ET'S a,nd radon crposure ue bolb risk factors for ltng =ccr, aad si : ;e one miy, eonfouad, or interaa .rith, tbe otbcr, a large ttudv designed to me .uure botb fauors as rcliably as possiblc would iuve cnosidcrablc sdcetific mcrit 191
GTS Z SdGZOZ tabl e 1 E viderrjiotogic Studies Prospective Studies Relative Risk 95'/. C.l. Hirayama (1981) 1 .63 1 .25 - 2 .11 Garfinkel (1981) 1 . 18 0 .90 - 1 .54 Case-Control Studies Trichopoulos, et ai . (1981) 2 .1 1 .18 - 3 .78 Chan & Fung (1982) 0 .75 0 .44 - 1 .30 . . ~ Correa , et al . (1983) Koo, et at. (1983) 2 . 03 1 .54 0 .83 - 5 .03 0 .90 - 2 .64 http://legacy.library.ucsf.edu/tid/wyk81f00/pdf Kabat & Wynder (1984) 0 .79 0 .26 - 2 .43 Wu, et al . (1985) 1 .2 0 .6 - 2 .5 Garfinkel, et al . (1985) 1 .12 0 .74 - 1 .69 Lee, et al . (1985) 1 .03 0 .41 - 2 .47 Akiba, et al . (1986) 1 .48 0 .88 - 2 .50 Datager, et af. (1986) 1 .5 0-8 -- 2-0 Pershagen, et at. (1987) 1 .28 0 .75 - 2 . 16 Lam, et al . (1987) 1 .65 1 .16 - 2-35 Koo, et at. (1987) 1 .55 0 .94 - 3 .08
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