ets exposure, lung cancer - Legacy Tobacco Documents Library

Fontham, E .T .H ., Correa, P ., Wu--Williams, A ., Reynolds, P .,
Greenberg, R .S ., Buffler, P .A ., Chen, V .W ., Boyd, P ., Alterman, T .,
Austin, D .F ., Liff, J ., and Greenberg, S .D ., "Lung Cancer in
Nonsmoking Women : A Multicenter Case-Control Study," Cancer
Epidemiolocry, Biomarkers & Prevention 1 : 35-43, 1991 .
Fontham, E .T .H ., Correa, P ., Reynolds, P ., Wu-Williams, A .,
Buffler, P .A ., Greenberg, R .S ., Chen, V .W ., Alterman, T ., Boyd, P .,
Austin, D .F ., and Liff, J ., "Environmental Tobacco Smoke and Lung
Cancer in Nonsmoking Women : A Multicenter Study," Journal of the
American Medical Association 271 : 1752-1759, 1994 .
Another American study was first published in 1991 by
Fontham and colleagues, as a preliminary report on a case-control
study of women in five U .S . cities . For all lung cancer cell types
combined, an odds ratio of 1 . 34 (95% CI 1 . 03-1 .73) was reported for
those women who reported that they were ever exposed to ETS in an
occupationall setting . Fontham and colleagues (1994) recently
published a report on all five years of the study . They present a
"crude" riskk estimate for workplace exposure of 1 .12 (955~ CI 0 .91-
1 .36), which changes dramatically after adjustment for a number of
variables to 1 .39 (95% CI 1 .11-1 .74) . The magnitude of the change
following adjustment is much more pronounced for the workplace risk
estimate than for the other risk estimates in the paper . Moreover,
the upward increase after adjustment_is suspicious . Fontham and
colleagues do not address this apparent discrepancy .
al . ., 1994 report :
http://legacy.library.ucsf.edu/tid/wyk81f00/pdf
Additional criticisms may be made about the Fontham, et