ets exposure, lung cancer - Legacy Tobacco Documents Library

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http://legacy.library.ucsf.edu/tid/wyk81f00/pdf
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ou. e .~ e. & .!a rrer .., ...M+w ',
Aome i Tmuhs or mae du+ini chWhood ChfldhoorJ
tivas defwd as thr iru 11 rears .rlie Eaye»ur$t (rom
parents after ehit t1me , .." cia»,f,e•d as other M,wetsold
mtmbers dunnj ad .,h ldt Dichotomous ETS e :powrn
wtrt firtt tUmrnad Itvtr rY Re+Trl bt type of tobaccoo
craarettes p'pr c,la•, or any of tMst tyqes of tobacto
pose w+s est'mared at approprure by M++emrry /t ` .
numbtr of crg+rrnes/darl, duurwn (e t, numbe, of
ynrs e .posrd' or a comb-nat,an it 1, pack•y .arnl Pack•
Ytt'n of ti{erette e .posure trom cht spouu arrt ca9cu•
l4rtd by mulr'ply,nl the numbtr of packr unolced ptr
dar b1 rht number of yte .rs the i.po%ne tenoktd e11arrnn
wfi,k 4vrni ~,,h tht ttudy subttrt rack•yeers of tapKture
wtrt eummed (or all r,nwk,ni tpouses of eaCh tWdr
wbttcf
Ont of the obtec+rvrs of thn etudy was to r-vaiwte
the essoc,ar,on of ETS with sptcifK hmopa+holo`icel cel+
types of fun& cancer 7he altwrd dntrrbutron of hatopatholog'cal
trpes prec)uded anis, mtanrntfuf ana)tsn by
tpe0 .c cell type orht, thin adenocaremoma arnd all
orher ceP sypt, comb~ned The reaults are presented /or
+11 (unb cancers tomb,ned In .. 420I .nd adenoc .*cmomas
cont,rmtd by 1+lstope's+ofog~cal reYreM (n . ={1) .
Cates wtre cornprtd so each control lroup wnh
re`ard to the d,vrrrbyt,on of rrle .ani co>aruur such as
aIt educat,on sncomt ar,d race/tthn~crtr The aswcr•
at,on of ETS tapoture w~th IUnti cancer rnk was dr ..estr
P+td Lrst rn eont,ngeneis ubks ttratrLtd by dnrfn oe
ump!mg .arables la`t, ract, u,.dr etnter) and eilevant
co .ar,ates Sumrna•y adsusted odds ratw+ and tett euus•
hcs v,ert caku4ied bt the mtthod of rvtantef and r4en .
sre) t)J) Uncond,t,orul tog,stuc rta-tss,orn analy>•n yrrtre
then used to ettmn+se the attocut,om by nummary ad•
jutted odds ratros, eonfrdtnce hrnns . and (nt wxrusei
q7 .14) .
te.arftt
DemoSraphic tharacneristrn !+t tasr+ and eewuroh are
presenttd in Table 4 Casts and eontrols wert u+nitar
evrth tnpen 6o matth,ns varubles and tnoel ieerw•
1 raphK wr,abtes The larlest ewmbt+ of ta6n in • 1tiQ
1141 were rts+dentt of tos Arqrln, Ootto-td Ivr eAetc
lrom ttu San irancnto sar Nta !n . 149, )S!k) . and
then the three t.mat(er Nudy centers h the southtrn
Unrted Statn AtLnta tn . ai, 1 t161 ; Moutton (n r»,
p•ti), and New Oritant /n r=i . trx1 .
The a=e d,st,ibution of tases arsd tonwoSs ts exvfoeen,
wnh f) to 74% of tach .erKS betwten the ain of Lo
ihrouo !1 The proponbn of otdtr .romen ws thsu {rovp
of fenute norumalen whh kml unttr 1t hsher thtn
...____._-.
w.. .r «r+~~
r» e,,., t.+
rN M~ i. rwr, .' ~t".u` mf r.w~. t+e~9*~
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thai antonl •A kr+,ak kRy cantrr cyu1 t't the SEER
irofram W4-1!!6, en wb+ch tanty 43% Mt eht Cases
were aRtd iS or esidtr E)S1 .
Cases tended to have a>,oR .ewfut Iorm isouse~d
1 .co+ne an$ kss eduut on than the popuUtwn tontro{s
P,tp a .,rnattY~ D51t, of castt$ tnd conrrob Upen+ t#een
rf. :tiood m crt,es wr>h poputatrons of 50 OOC or tnae
and rnt enatornY of uses and tontrolt f70% i8% ,17f+
for taets Colorr Cancer conr,ols and populas,e,+, cor+troo .
tetptctrr2ly) rnrded en CArn durdy r+rasr of tM•r aduh
Mft . The ntrnuttd r:sks of IvnS unctr In no+srnoArtq
women astocattd w9h gve, hav,n` Ir .t•d wnh a ~t
who tmoked are plestrtited .+Tabk S The adtusttd Olls
and tht 1S'r. Ct are verr e+m,tar (or en tpoutio-ralaud
eepo+ures reEardkss of controt Sroup for ali h,srotyth•
olo{,csl tyrpes of )und tance comb,ned a 10', . srycrtau
r, rrsk rs obur.3d lOt . 1•SI and 1,Y4 wnh coko++ea+_et
and populat,on tontrotst For tath of tht thrte rvpt, of
tobacco trrsaled the ORs ranged from 1 14 to 1,36
When thr case ser,ts rs tetrrtoed to the Sit ®ulrnorteR
adenocarca+omas conr,rmed bv h t+opa+t oto= ca~ n .+t . .
the ast•acur,on it mort pronounced Appro .,marNr Sa%
ekvat+ans m rnl of adenocartrnor?,as of tht Ivn= 1t s
p OS1are assocured wrtt•.anr s»p ar tabacco by tpoustts) .
and cla,ettt smolinj accounts for n+ost of the tobacco
vu The ewnuted rt4t, .t rnk of pufmawh ad+noctr•
t,nomi associated .smh tr`a,ttte tnnoLms by eto'uttr
was 1•)i 1142•1 .N1 W+th tht poputtitron tontrois as
comparrton and 1 .31 (0 }e .1 1 .t1 wnh she cobn carce+
tonnolsascomparM1On No~ettotUl,onbtlweMtpOUi4f'
lobacco vst and bunf eancen oahe, than adrnocrcr
rr,rru tsquamous tetl . M>+tI tei!, ierse cell, and other ; Fit
. ~/I was observed . '
Sepa,att ana)nn .rtrt tonduc+ed cor wbtent .Mto
prr .onallt rtspondtd and So+ whtm mtornyt,on a+ys
obumed (som eurolate rnp"ents The tadds satrot tyr
involuntary tapotute to ET5 were very oreni{ar fot droth
groups of tespondtnts ; thtrefore, the eetuhs set noe
presensed in the ubtts etparate)r by trp* ol neaondrru-
Orne such tumpk 11 tht ty1,RUted tetalwt rnk of e++onary adenoca ctnorvs a+wcuted wrth erp*tnt
vnol,na by tht spouu OR . 1 .18 and 11 .110 to+ eunoµte
and reif•rtrponden7l, Ieropectn,tlY, tompar,na use+ eo
eofon Canctr eoetirph .
tffedts by ttsrdr tenttr wert at .o t .amrntd Yke
odds rafros bY censer ranled froM a bw of 1 .17 to a hrit,
of S i4 to, rnl of pulmonart adenocarunoma assoeetttK! ~
with tpc,usn'tiL arnu .mok,nl drreust of the kmntd ~
6ampk wn . nona of N .e rnd,vrd"l suudv eentet aqt .• ~ .+
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