ets exposure, lung cancer - Legacy Tobacco Documents Library

csrciaomt of de IYnj (latctaatlosl
Ctauifrcalion of Diseases for OwcoloYy
Codes 162 .2•1629) that wu Iuinosed
•et..ten April l, 19E7, sad fcbnary, 28,
1991 . and if they resided at tMe time of
Iiapnosis in a 2K'-ounl ; area ia tratral
florid . These women ucrc idcnlified
tlrrourh the tumor rcFisuics of area "•
iaital% and thc floriJ . Canccr Data SW
t,cm of the Statewidc Cancer kcgrstry .
Conuol s,ubjects wrrc community bascd
sad Mcrc identificd through rsndom•
Jijit dialing All casa patients and con•
trol .uhjccts Mcrc lifetime rMnsmol .erN .
cLcfineJ as Iuvint unnkW fcx a totat of
k~a than h snonths nr kavinj a>rwlcd
(cxs shan tfpl cijarcr(cs in thcir Iifc•
timCs
The umr+lin ; status of potential nac
ptient, in the atudl was enn(irrned at
teverrl at .~ca Oncc Shcr,e individual,
wer : iJrnriG,;J hy thrir hrrspital crr thc
Statcw idd C'aneet Kcyi .tr) rceord .,thcir
ftmolink status was eunfrrmcd when
their physician wa .s eonl .cted fur per•
taission to interview, again at the time
of initial contact with the patient or nezt
of kin, and, finally, at the eommence•
ment of Ihc interviev . . In adJirion, the
laten'uw eontained questions retardinj
esperimentalion with tobacco, desijned
b elicit in a aculral rnanner any prior
trndisclosed tobacco use Any potential
case patient whose smoking ssatus could
wot he confirmed vvs escludcd, Of
thou found to he eli=ihte, e0% of ths
eut patients or their nezl of kin agreed
to Ix inlerviewed The tmol•inj itatus
of eonarol wbjocts w as determined dur•
int random-di;il dialint and verified
during the interview .
Trained inurview•ers inurviev.ed casc
paliertss and control subjeets either in
pcrson or overthc telephone . When sec•
essar% . questionnairca wcre ruiled . Of
the ease palicnt inter .•iews, l1'>E werc
obtaintd hy in•person eorsuct, 51% by
kscphont, and 8% by mail . Of the eon•
tro! tubjen interviews, 53•8rl %LYre ohuine
;i by in•person contact, 15 .9% by
teiephone, and 0•34E by aaaii• tatormed
cvnsrnt was obtained from t1u esic pa•
tienis and control tubjens prior to the
intcrrie>~s according to the guidelines
of the University of South Florids inui-
Wtional Revicr< 8oard, The iaterview
i.cludcd questions on environmental toa
bacco cmoke esposures at bome, on the
)o6, and in aocisl uttings . IJ csse pa-
http://legacy.library.ucsf.edu/tid/wyk81f00/pdf
tieasa were bo 11I b be iwservitaed tx
wcre ieceascd . aurroiau teapoadcats
(prirnarily ltusbands and children) were
satcrvicwcd toterviews of tunotste ntpondenu
were .ecxsury (or 66 .7'!E of
the case patients
Odds ratioa (OiCs) were calcutsted to
csuimate the relative risks Multiplc bo••
gislic regression analyses were per•
(ormcd using the SAS L.OCi1ST7C procedure
(SAS Institute . Cary . N .C .) .
Nlnety•fiive pcrccnt cortfidencc imcrvala
(Cii) were calcvlated from tMe lotistic
tnodets . The chi•square statistic was
wcd to text (or trcnd,
Ruults
The stud) p{omewkal oldet and lud fewer 7tart
of tomul .ducalion thu, vontrols, with
a tijniftcam trend of is,creuinj lung
cancer risk with dccreatint years of
fchoolint (P . .tl19) AMwss half of the
uu patients and control tubjcns irad
lived in Florida for at ieasl 2/) years
Table 2 iwditatcs the OKS and 459E
Cis associated with ezposure to cig .•
rettc tmokc fsom parenti, tihlinta, Au .-
I+ands, and o(her Isauuhold membcn,
after adjuslment (nr age . racc, and
[ducatKfn . UnctpncCd Kdividual, wcrc
Ua.c with ae lanuscbold envirrmrncntal
tohacco unokc etpowre, Wc der .crihc
exposure i . ecrnu of uswkc•ycar ., dc•
fined u• the sum of the reporscd years of
e :pnaurc to eitarettc tmnkc (nxn each
amnker in thc househnld We rnnxidcred
arswlc•ycan% to hc a moee reliable rr.casarc
of exposurc than pack-years, aincr
ttudy panicipants had ltss difficulty realling
tha Rumber of years they lad
lived with someone WMo uenoked tlsan
recalling the tsurnber of cigarettes per
day to which they had been ezpoud•
Smoke-years were subdivided into thres
eatejories of approxienately equal size
Tal6k t . OnarRrmw~ st sIw_w1 cMnaneriwic. a( are rrinw "/ tata.eni WAJcV .
C ... Mrir.n ( . . Ztnt' C.wnt ..b)cet. ( . . jUl)•
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