ets exposure, lung cancer - Legacy Tobacco Documents Library

1st f N LE F a .r
when possibk, hospital ward and tsme of sntrrr»cw .
SuMtpu•.ntly, whcn final discharge dtaFnoscs
txs.arrx avatlahk . thcy were used to rcalloute asts
and controls as s+eersvry Patients without a finxl
diagncx_is keT+t thcir (xovrstonal draFnosts Where
chanEcs m casctontrol sratus oaurrrd, paticnts
were rcgroufrd intn nrw osetontrol pairs as
appropriate With the asststancr of Sir Rschard
Doll s+r,d Mr Rw•h,,rd Petu, non-tndcs duEnoses
werc classtficd as follows
ciass tA 'definitely not smoking associated'
clau 18 'probably not smoking associated'
class 2A 'prob+bly smoking assoaated'
class 2B 'dcfnttely smoking assactsted'
Controls with no final diaFnosts were considered
class tB Ovcrall, thcrc were 12,693 intcrviews
carried out which srsulted in 4 .950 pairs with class
I controls and 73P patrs with class 2 controls .
Ttyer : wcrc 3 .g3 : interviews of marrtcd cases and
controls whcrc the passive smoking qucstionnaire
was completed In order to avoid substantial bu of
data, duc to one mcmbcr of a pair rsot being
marrscd or not compkttnE thc pauivc smoking
qucstionnairr„ it .as decidcd to ignore matching
when anatysinj thc pauire smoking data and to
comparc cach rndca sroup with the combir>ed
controls Numhcrs by acs and asccontrol status
•re riven in Tablc 1 .
Tab1e I Numhers c/ msrmd twspital in-patsents
ownt+tct nt p.u,ve amol:mj rJuesttonaatrn
Mat. fe.rk Ta+at
Lunt canat $47 245 792
t'hronK broechttu 182 N 266
(sehaemK Mean dtsease 216 221 !0'f
Stroke 161 137 2!1
Contvok
Clas, tA and 1!1' 8)9 713 1J52
Lhasr. 2A and 2!S` 2" 149 417
Total 2.213 1549 U32
'Othcr dnc.asos .rtrs dauift.d by dclFnc a( asokins
wocutrcro - dass IA rkfiatsety wot, dass 1t MobOWy
tol, das 2A prohably, dan 2! 6cfrrutely
In the pass+vc amo .rns prrt ol the questionnaire,
patients wrn: asked whcn the aurrute siart .d, if
and when it had andod ; the lumber of
osanufactured ciprtttes per day smoked by the
spuuse both during the last 12 months of aurtia`e
asud also at the period of maaimum smoking during
the nlamaje, and whether the spouse oMer ttYutarly
smoked hand-rolled eiprettes, dprs Gr a pipe
during the marriatc For amnnd or subsGquent
tsarruga, queuwru related to the Gru anarria=c to
http://legacy.library.ucsf.edu/tid/wyk81f00/pdf
give the IonEcst taunt snterval bctwecn exposure
and dtseasc onset The S+attcnu wert also asked to
quanttfy, acxord+ng to a four•potnt acak > ;a lot,
average . a kttk, not at all), the extent to which they
were reEularly esposed to tobacco smoke from
othcr rcoplc fxior to comtnF tnto hospital in 4
ssituations at horne, at work ; dunng daily travel,
dunng ktsure tisrse, In the main qsses .tionnain,
dutaik-d qucsttons wcrc askcd on smoking habits
and on a whole ranFe of possibk confoundtng
variabbes
Follo .-srr Nsd) of Jpousas of raon-smoli+sX looaptrel
An-patwnts
From the hospital study thcre were 56 lung tan=r
qws who reponcd being hfclong non-smotien,
who werc marncd at the time of intervier and who
were not known to have bccn married previously
In a follov.•up to the main study, an attempt was
made to intcrvxw the spouses of thcse $b cases and
also ihe spouses of two hfe-lont non-smokine
controls for tach ase, indtviduxlly matched for ses,
tvuntal status and 10-ycar arc group and, as far as
possibl ., hospital Where multtpk potential cAntrols
in the same hospital wcrt available, thoac
intervicwcd warest in time to the case were
selected Whcre suitablc controls in the samc
hospital were not a~ailabk, thoss in the nearest
Isosptul werc ehoun
because names and addresses of the patients were
ssot recorded in the hospital study, st was neacssar)
to to back to the hosp,tal both to obtain this
information arid also to get pcrmtsston to intervxu
their spouses FollowinS some nefusaVs both by the
iwsprtal and by the tpousrs . sucrosful intervsews
were obtatrsed from spouses of 3 ; cases (10 wives
and 24 husbands) and 90 controls (26 wives and 5A
Musbands) whosc condition was definitely or
probably not related to smoking
Intcrvsewinf was carried out between July 19$2
and August 1913 The spouses were asked about
their eonsumrtson of manufactured cigarettes,
t:iFars and pif+cs (a) rsowadays, (b) dunng the year
of admrssion of the patient or (c) maximum durinf
the whok of the rnarrsagc The spouses wKrs oot
asked about the smoktng hatwts of the i+rdes
prtsent The sf+ouus wne also ∎sked questiont on
sEe, oerufutson, aoetal elass and a range or othcr
potential confounding factors .
Starisrirol awraAods
The statistical methods ars kused on eiassiesl
proocdures (or analysis ot Srouped data derived
frorn nse-eontrol studies (Breslow & Day, 1980)
In Senenl, the material Aat been etumincd as a
2 x K x S tubk, with A' rcj+rescnting the levels of the