ets exposure, lung cancer - Legacy Tobacco Documents Library

1or both wfy aad adult years . Tis distribution
of unoke•years of exposurc
vas snuch lowr:r tor sarly ytan, pri•
wrily beeause ptrtieipents te*ded to
/ive with tpouscs for anorc ytan lhan
Mey had lived with their parents• rtar+lt•
404 in bwer eutoff points .
Lant cancer riek estimstcs for .vomen
who wcre ssposed to environmr :asl
Iobacco smoke during childhood and
sdolcsccncc sre shown in Table 2 .
When we cakuh'ed the tisk sstociated
wUh esposure to smoke from family
wcmhers on an individual hasis
(rwother, Athct, eihlin=s, and others) .
Mcrc wes a slight incrurc in risk fnt a11
trrfwx.ura., althtw ;h the inerea>,e% ir, rial
were t+nt tastiraically sitnificant . F1e+w•
e.rer . %%hcn we alculated risk ncewdin ;
1o cmcste•yrars of expowrc, which rc•
lkn,, total ccpcrwrc to unokc from all
brw .cMilJ memhera, a >itnificantly clc•
raled ri" of 2 .4 (9S'% (.'1 a i .l•5 41 was
ot+aervcd for women expoacd 22 years
4111' more .
Table 2 also shows the effect of en•
wironmcntal tobacco smoke exposurt
iurine adulthood on lun; cancer risk .
Women who lived for 111 or more years
ef their adult lives with husbands and
•ther individuals who smokcd were
found to Iavc ae elevated risk of 2 .4
(95'i ta a If we eonsidere.d
only smoke exposure from husbands tor
40 or more smoke•years (data not
shown), the riek ealimate deereascd
slijhtly to 2 .2 (95% Cl ∎ 1 .0-4 .9) .
Is terau of sout IiGetiree rrsaoke•ysan
ot expcwrs (Tabte 21, ao nIt+rifresst exaeu
risfs were obterved for wornen re•
pning fs+ver than 40 liftsirwe saokt•
yean, but wwnen teportinj 40 oe teore
years of exposure experieated an e)e•
vsecd lrng eanrer risk of 2J (959E l:.•l .
1 .1-r .6) .
We elso r:xamined the relationship
between the lung cancer ritk assotinted
with environmental sobaceo srnokc es•
poaurc and lun ; cancer tslliype . Sinct
61 .4% of the lung ancen is the study
were adenocarcinomas, all fant anr:er
kiuolotien orher tMn adenesrareinoma
wore enrnhined in one graep for anal•
yxi>_ Rie,k craimatcc for snu+k.c-yeara of
expn .urc were aleulated esparatcly kx
the two Croups, and (he results arc
shown is Table 2 .
Pot womcn h ith .denocareinorna . the
risk& wcre sJiFhti) elevated for all ate-
Rnric+k of smoke exposure, fwt the tccuitt
did sot achieve ttatistical
significance . Women with fwn•adenoeareinoma
lunt ancert, on the other
kand, showed sitnificantiy elevated
risks when their exposure to environmental
tobacco smokc was of lonL duration
. The OR indicated a threefold
increased risk of lung cancer (or women
who rcponed 22 or more rmoke•years
of exposure from parents, siblints, atxM
others during ehildhood and adolee•
ccncc (OR ∎ 3 .4 ; 95% Ct .
Similarly• women with 40 or more years
of adulthood exposure to unoke from
Iwrxbands aad oeb,er bo.es>rotd a.pwkery
s:pcrie .ced a eignifieaat etsvatioa is
risk (OR a 3-3i 95% CI a 1 .1•4 .1i3 .
Wken total lifetiRne sspoars to savironmental
smoicc was otesidend, thc
ORwas3 .3(95teCt .124 9) tarthe
lriRhest expowre kvtl, for womea vith
rron•sdenocarcinr+ma lurti cancers, there
was a statiuicatly sipnifirant trend of
iracrcasing risk auaciatcd with incrsasinR
smcrke•yean of sxposnrr for each
typc of e :posun (cfiildhood . adulthood,
.nd lifetime) .
Sinee sunoCatc rrspowdents wcrc required
for ahnut two IAirds of the ea .c
paticnt intcrviews• we iaveslipatad
w#cthcr the fknuree e,f the ar .e pallent
intcrvicw (xel(-respnersient verwe, wrrn•
5atc re4ondcnt) sffened the riik cFtitautex
. Surrogate rrspo .dra,s for cau
patients were divided iato two jroupt,
"Muxhands" and "oaher surrngate% ."
the tarter trrwp conxistini ; primarily of
aon,, and dauthten . Tbc tosHlts of Ihis
an..lyaix arr: shown in Tahie ` . $eeauu
the'urnber of respondents ia twme ate•
:oria was vsry srtult, analysis of risk
associated with exposure to tmoi.e from
individual household rnemhers is
limited to fathers and (tusbands . In eomparison
with thc risk ectimatcs for
women whose interviews were "m•
pleted by themulva a by ifcir !wsbands,
the ritk etiimata kr woaxn ir
the "other surrogate" respondent att•
sory were eonsidcrably krwer . This rt•
tult wat trve both far tisk associatcd
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